Prevalence of Mental Health Disorders Among Individuals Experiencing Homelessness: A Systematic Review and Meta-Analysis.

Importance: Several factors may place people with mental health disorders, including substance use disorders, at increased risk of experiencing homelessness and experiencing homelessness may also increase the risk of developing mental health disorders. Meta-analyses examining the prevalence of mental health disorders among people experiencing homelessness globally are lacking. Objective: To determine the current and lifetime prevalence of mental health disorders among people experiencing homelessness and identify associated factors. Data Sources: A systematic search of electronic databases (PubMed, MEDLINE, PsycInfo, Embase, Cochrane, CINAHL, and AMED) was conducted from inception to May 1, 2021. Study Selection: Studies investigating the prevalence of mental health disorders among people experiencing homelessness aged 18 years and older were included. Data Extraction and Synthesis: Data extraction was completed using standardized forms in Covidence. All extracted data were reviewed for accuracy by consensus between 2 independent reviewers. Random-effects meta-analysis was used to estimate the prevalence (with 95% CIs) of mental health disorders in people experiencing homelessness. Subgroup analyses were performed by sex, study year, age group, region, risk of bias, and measurement method. Meta-regression was conducted to examine the association between mental health disorders and age, risk of bias, and study year. Main Outcomes and Measures: Current and lifetime prevalence of mental health disorders among people experiencing homelessness. Results: A total of 7729 citations were retrieved, with 291 undergoing full-text review and 85 included in the final review (N = 48 414 participants, 11 154 [23%] female and 37 260 [77%] male). The current prevalence of mental health disorders among people experiencing homelessness was 67% (95% CI, 55-77), and the lifetime prevalence was 77% (95% CI, 61-88). Male individuals exhibited a significantly higher lifetime prevalence of mental health disorders (86%; 95% CI, 74-92) compared to female individuals (69%; 95% CI, 48-84). The prevalence of several specific disorders were estimated, including any substance use disorder (44%), antisocial personality disorder (26%), major depression (19%), schizophrenia (7%), and bipolar disorder (8%). Conclusions and Relevance: The findings demonstrate that most people experiencing homelessness have mental health disorders, with higher prevalences than those observed in general community samples. Specific interventions are needed to support the mental health needs of this population, including close coordination of mental health, social, and housing services and policies to support people experiencing homelessness with mental disorders.

The relationship between rurality, travel time to care and death by suicide.

BACKGROUND: We previously found an association between rurality and death by suicide, where those living in rural areas were more likely to die by suicide. One potential reason why this relationship exists might be travel time to care. This paper examines the relationship between travel time to both psychiatric and general hospitals and suicide, and then determine whether travel time to care mediates the relationship between rurality and suicide. METHODS: This is a population-based nested case-control study. Data from 2007 to 2017 were obtained from administrative databases held at ICES, which capture all hospital and emergency department visits across Ontario. Suicides were captured using vital statistics. Travel time to care was calculated from the resident's home to the nearest hospital based on the postal codes of both locations. Rurality was measured using Metropolitan Influence Zones. RESULTS: For every hour in travel time a male resides from a general hospital, their risk of death by suicide doubles (AOR = 2.08, 95% CI = 1.61-2.69). Longer travel times to psychiatric hospitals also increases risk of suicide among males (AOR = 1.03, 95%CI = 1.02-1.05). Travel time to general hospitals is a significant mediator of the relationship between rurality and suicide among males, accounting for 6.52% of the relationship between rurality and increased risk of suicide. However, we also found that there is effect modification, where the relationship between travel time and suicide is only significant among males living in urban areas. CONCLUSIONS: Overall, these findings suggest that males who must travel longer to hospitals are at a greater risk of suicide compared to those who travel a shorter time. Furthermore, travel time to care is a mediator of the association between rurality and suicide among males.

Fed- and Fasted-State Performance of Pretomanid Amorphous Solid Dispersions Formulated with an Enteric Polymer.

Weakly acid polymers with pH-responsive solubility are being used with increasing frequency in amorphous solid dispersion (ASD) formulations of drugs with low aqueous solubility. However, drug release and crystallization in a pH environment where the polymer is insoluble are not well understood. The aim of the current study was to develop ASD formulations optimized for release and supersaturation longevity of a rapidly crystallizing drug, pretomanid (PTM), and to evaluate a subset of these formulations in vivo. Following screening of several polymers for their ability to inhibit crystallization, hypromellose acetate succinate HF grade (HPMCAS-HF; HF) was selected to prepare PTM ASDs. In vitro release studies were conducted in simulated fasted- and fed-state media. Drug crystallization in ASDs following exposure to dissolution media was evaluated by powder X-ray diffraction, scanning electron microscopy, and polarized light microscopy. In vivo oral pharmacokinetic evaluation was conducted in male cynomolgus monkeys (n = 4) given 30 mg PTM under both fasted and fed conditions in a crossover design. Three HPMCAS-based ASDs of PTM were selected for fasted-state animal studies based on their in vitro release performance. Enhanced bioavailability was observed for each of these formulations relative to the reference product that contained crystalline drug. The 20% drug loading PTM-HF ASD gave the best performance in the fasted state, with subsequent dosing in the fed state. Interestingly, while food improved drug absorption of the crystalline reference product, the exposure of the ASD formulation was negatively impacted. The failure of the HPMCAS-HF ASD to enhance absorption in the fed state was hypothesized to result from poor release in the reduced pH intestinal environment resulting from the fed state. In vitro experiments confirmed a reduced release rate under lower pH conditions, which was attributed to reduced polymer solubility and an enhanced crystallization tendency of the drug. These findings emphasize the limitations of in vitro assessment of ASD performance using standardized media conditions. Future studies are needed for improved understanding of food effects on ASD release and how this variability can be captured by in vitro testing methodologies for better prediction of in vivo outcomes, in particular for ASDs formulated with enteric polymers.

Help-seeking behavior among adults who attempted or died by suicide in Ontario, Canada.

INTRODUCTION: This study aims to determine the relationship between rurality and help-seeking behavior prior to a suicide or suicide attempt. METHODS: Data from 2007 to 2017 were obtained from administrative databases held at ICES, which capture all hospital, emergency department (ED), and general practitioner (GP) visits across Ontario. Rurality was defined using the Rurality Index of Ontario scores. Help-seeking was based on accessing health services 1 year prior to the event. RESULTS: Among those who died by suicide (N = 9848), those living in rural areas were less likely to seek help from a psychiatrist (rural males: AOR = 0.42, 95% CI = 0.31-0.57; rural females: AOR = 0.46, 95% CI = 0.29-0.97) compared with those living in urban areas. We found a similar association among those who attempted suicide (N = 82,480) (rural males: AOR = 0.49, 95% CI = 0.43-0.56; rural females: AOR = 0.51, 95% CI = 0.46-0.57). Rural males and females were more likely to seek care from an ED for mental health reasons compared with urban males and females. CONCLUSIONS: Among people who died by suicide, those living in rural areas are generally less likely to access psychiatrists and GPs and more likely to access EDs, suggesting that people living in rural areas may have less access to care than their urban counterparts.

Placement Architectures in Practice: An Exploration of Student Learning during Non-Traditional Work-Integrated Learning in Rural Communities.

BACKGROUND: Work-integrated learning (WIL) in rural communities provides students with important learning opportunities while also providing a service to those communities. To optimise the potential benefits of work-integrated learning for health students and rural communities it is important to explore the practices and outcomes of these experiences. METHODS: This study used a qualitative research design underpinned by the theoretical framework of Theory of Practice Architectures to examine the way students learn during these placements. Purposive sampling was used to identify students for participation in the study. Seven students from the disciplines of paramedicine, physiotherapy, and speech pathology participated in semi-structured interviews. Data were analysed using inductive thematic analysis. RESULTS: The learning described by the students was examined, followed by a critical interrogation of the data to assess how these learnings and associated practices were made possible given the site-specific practice architectures. The findings of the research are represented by three themes: learning affordances related to placement design, learning through relationships between people and professions, and learning through rural embeddedness. CONCLUSION: Being embedded in rural communities gave the students access to several arrangements that fostered learning, particularly through the sayings, relatings and doings that the students engaged with. This research demonstrates the transformative potential of rural WIL opportunities for learning and future rural practice.

Toxicity and toxicokinetic assessment of an anti-tubercular drug pretomanid in cynomolgus monkeys.

Pretomanid is a nitroimidazooxazine antimycobacterial drug that was approved in more than 10 countries as part of a three-drug, all oral regimen, consisting of bedaquiline, pretomanid, and linezolid (BPaL) for 6-months treatment of adults with pulmonary extensively drug-resistant tuberculosis (XDR-TB) or with complicated forms of multidrug-resistant tuberculosis (MDR-TB). The toxicological profile of pretomanid was thoroughly evaluated in repeat-dose oral toxicity studies up to 39 weeks long in cynomolgus monkeys. Exposures up to 10-fold higher than in humans at the approved pretomanid dose (200 mg) were achieved in acute studies allowing for characterization of dose-limiting toxicity. Target organs and processes identified in acute and chronic toxicity studies included QT prolongation, nervous system effects, and liver effects (minimal hepatocellular hypertrophy without elevations in liver enzymes). In a 13-week study, no cataracts were present at the end of dosing, but 2 of 12 monkeys had cataracts at the end of a 13-week recovery period. No cataracts related to pretomanid administration were observed in subsequent 13-week or 39-week studies. No male reproductive toxicity was observed in these studies. No-observed-adverse-effect levels (NOAELs) were identified in all studies. Exposures at the NOAELs equaled, or exceeded, human exposure at the approved pretomanid dose with the exception of female monkeys in a 39-week chronic toxicity study. These data support the use of pretomanid as part of the 6-month BPaL regimen for treating XDR-TB and MDR-TB.

Assessment of the Carcinogenic Potential of Pretomanid in Transgenic Tg.rasH2 Mice.

Pretomanid is a nitroimidazooxazine antimycobacterial drug that was approved as part of a three-drug oral regimen, consisting of bedaquiline, pretomanid, and linezolid, for 6-months treatment of adults with pulmonary extensively drug-resistant tuberculosis or with complicated forms of multidrug-resistant tuberculosis by the food and drug administration in the United States and regulatory bodies in over 10 other countries. Nitroaromatic compounds as a class carry a risk of genotoxicity and potential carcinogenicity based on reactive metabolite formation. A battery of good laboratory practice genotoxicity studies on pretomanid indicated that the compound was not genotoxic, however its hydroxy imidazole metabolite (M50) was genotoxic in the Ames assay. To assess the in vivo carcinogenic potential of pretomanid, hemizygous Tg.rasH2 mice were administered pretomanid once daily by oral gavage for 26 weeks. Male mice were given pretomanid in vehicle at doses of 0, 5, 15 and 40 mg/kg/day and female mice were given pretomanid in vehicle at doses of 0, 10, 30 and 80 mg/kg/day. Positive control mice of both sexes received intraperitoneal injections of urethane at 1000 mg/kg on Days 1, 3 and 5. There were no pretomanid-related early deaths, tumors, non-neoplastic microscopic findings, or gross necropsy findings at any dose level. The positive control gave the anticipated response of lung tumors. Oral administration of pretomanid to mice produced plasma exposure to the parent compound (high dose AUC of pretomanid 3 times the clinical AUC at the maximum recommended human dose) and exposure to the M50 metabolite (less than 10% of pretomanid) at all dose levels in both sexes. These data show that pretomanid was not carcinogenic in a transgenic mouse model at systemic exposures greater than human therapeutic exposures.

Hazardous alcohol use and alcohol-related harm in rural and remote communities: a scoping review.

Alcohol use is a major risk factor for death and disease worldwide and alcohol-related harms appear to be more prevalent in rural and remote, relative to urban, communities. This Review synthesised international research on rural-urban disparities in hazardous and harmful alcohol use and risk factors for these outcomes within rural and remote communities. 280 studies from 49 countries were included in the Scoping Review. Most studies (60%) found rural, relative to urban, residence to be associated with an increased likelihood of hazardous alcohol use or alcohol-related harm. This proportion increased between 1990 and 2019 and varied by country, age group, and outcome type, being highest in Australia, among young adults, and for more severe alcohol-related harms, such as drink driving and alcohol-related suicide. Improved public health strategies to reduce the burden of alcohol use in rural communities are required but their efficacy will depend on how well they are tailored to the unique needs of the region they are implemented in.

Rurality as a Risk Factor for Attempted Suicide and Death by Suicide in Ontario, Canada.

OBJECTIVE: This study aims to examine rural and urban differences in attempted suicide and death by suicide in Ontario, Canada. METHOD: This is a population-based nested case-control study. Data were obtained from administrative databases held at ICES, which capture all hospital and emergency department visits across Ontario between 2007 and 2017. All adults living in Ontario who attempted suicide or died by suicide are included in the study, and controls were matched by sex and age. Suicides were captured using vital statistics. Suicide attempts were determined using emergency department service codes. RESULTS: Rurality is a risk factor for attempted suicide and death by suicide. Rural males are more likely to die by suicide compared with urban males (adjusted odds ratio(AOR) = 1.70, 95% confidence interval (CI), 1.49 to 1.95), and the odds of death by suicide increase with increasing levels of rurality. Rural males and females have an increased risk of attempted suicide compared with their urban counterparts (males: AOR = 1.37, 95% CI, 1.24 to 1.50) (females: AOR = 1.26, 95% CI, 1.14 to 1.39), with a pattern of increasing risk of suicide attempts with increasing rurality. Rural females are not at increased risk of suicide compared with urban females (AOR = 1.08, 95% CI, 0.80 to 1.45). Sensitivity analyses corroborated the results. CONCLUSIONS: Rural males are almost two times more likely to die by suicide compared with urban males, and both rural males and females have an elevated risk of suicide attempts compared with urban residents. Future research should examine potential mediators of the relationship between rurality and suicide.

Co-designing community-focused rural placements for collaborative practice.

AIMS AND CONTEXT: As a University Department of Rural Health, we have identified recurrent areas of service need among vulnerable rural populations, specifically the need for allied health. Concurrently, we have also identified missed opportunities for deliberate collaborative practice in rural clinical placements. This paper provides a commentary on our work in progress as we work to leverage available opportunities to provide both service from and education for health profession students on rural clinical placements. APPROACH: We developed a transdisciplinary placement model, informed by practice theory, which encompasses pre-placement preparation, student support, host sites and clinicians, and a structured evaluation strategy. This model aims to facilitate service provision alongside of student learning about community and collaborative practice. In particular, the co-design of the model is expected to facilitate student's sense of social accountability and reduce stigma in working with vulnerable population groups. CONCLUSION: This paper highlights the need for greater alignment between rural health education and practice, describes a placement model that is working towards this and showcases how this has been enacted in a remote community in New South Wales. More cross-sector discussion and evaluation is needed to determine the implications of adopting this model more widely if service and learning opportunities are to be equally achieved, and to determine the ways in which training and service provision can be aligned with community need, as recommended in the recent Rural Health Commissioner Report.

Rurality and Risk of Suicide Attempts and Death by Suicide among People Living in Four English-speaking High-income Countries: A Systematic Review and Meta-analysis.

OBJECTIVE: Previous research indicates a potential relationship between rurality and suicide, indicating that those living in rural areas may be at increased risk of suicide. This relationship has not been reviewed systematically. This study aims to determine whether those living in rural areas are more likely to complete or attempt suicide. METHOD: This systematic review and meta-analysis included observational studies based on people living in Canada, the United States, the United Kingdom, and Australia. Data sources included PubMed, EMBASE, PsycINFO, and Google Scholar from January 2006 to December 2017. Studies must have compared rural and urban suicide or suicide attempts. Nonprimary research articles were excluded. RESULTS: A total of 6,259 studies were identified and 53 were included. Results indicate that males living in rural areas are more likely to complete suicide than their urban counterparts (RR = 1.41, 95% CI, 1.21 to 1.64, I2 = 96%). Females in rural areas are not significantly more likely to complete suicide (RR = 1.16, 95% CI, 0.98 to 1.37, I2 = 79%). Among studies that only reported combined estimates, rural individuals are more likely to complete suicide (RR = 1.22, 95% CI, 1.11 to 1.33, I2 = 98%). There is no association found between rurality and suicide attempts (RR = 0.93, 95% CI, 0.73 to 1.19, I2 = 85%). CONCLUSIONS: Those living in rural areas are more likely to complete suicide, with some studies indicating that only rural males are more likely to complete suicide; these findings are relatively consistent across all four countries. Public health initiatives should aim to overcome geographic variation in completed suicide, with a particular focus on rural males.

Incidence and Prognosis of Acute Kidney Diseases and Disorders Using an Integrated Approach to Laboratory Measurements in a Universal Health Care System.

Importance: Abnormal measurements of kidney function or structure may be identified that do not meet criteria for acute kidney injury (AKI) or chronic kidney disease (CKD) but nonetheless may require medical attention. The Kidney Disease: Improving Global Outcomes Clinical Practice Guideline for AKI proposed criteria for the definition of acute kidney diseases and disorders (AKD), which include AKI; however, the incidence and prognosis of AKD without AKI remain unknown. Objective: To characterize the incidence and outcomes of AKD without AKI, with or without CKD. Design, Setting, and Participants: Retrospective cohort study including all adult residents in a universal health care system in Alberta, Canada, without end-stage kidney disease (ESKD) and with at least 1 serum creatinine measurement between January 1 and December 31, 2008, in a community or hospital setting. Data analysis took place in 2018. Main Outcomes and Measures: The Kidney Disease: Improving Global Outcomes guideline definitions for CKD, AKI, and AKD based on serum creatinine, estimated glomerular filtration rate, and albuminuria criteria were applied to estimate the proportion of patients with CKD, AKI, and AKD without AKI, and combinations of the conditions. Patients were followed up for up to 8 years (study end date, June 31, 2016) to characterize their risks of mortality, development of new CKD, progression of preexisting CKD, and ESKD. Results: Among 1 109 099 Alberta residents included in the cohort, the mean (SD) age was 52.3 (17.6) years, and 43.0% were male. Findings showed that AKD without AKI was common (3.8 individuals without preexisting CKD and 0.6 with preexisting CKD per 100 population tested). In Cox proportional hazards and competing risks models over a median (interquartile range) of 6.0 (5.7-6.3) years of follow-up, AKD without AKI (compared with no kidney disease) was associated with higher risks of developing new CKD (37.4% vs 7.4%%; adjusted sub-hazard ratio [sHR], 3.17; 95% CI, 3.10-3.23), progression of preexisting CKD (49.5% vs 34.6%; adjusted sHR, 1.38; 95% CI, 1.33-1.44), ESKD (0.6% vs 0.1%; adjusted sHR, 8.56; 95% CI, 7.32-10.01), and death (25.8% vs 7.3%; adjusted hazard ratio, 1.42; 95% CI, 1.39-1.45). Conclusions and Relevance: Criteria for AKD identified many patients who did not meet the criteria for CKD or AKI but had overall modestly increased risks of incident and progressive CKD, ESKD, and death. The clinical importance of AKD remains to be determined.

Kidney Function, ACE-Inhibitor/Angiotensin Receptor Blocker Use, and Survival Following Hospitalization for Heart Failure: A Cohort Study.

BACKGROUND: Angiotensin-converting enzyme inhibitors/angiotensin receptor blocker (ACE-I/ARB) improve outcomes in patients with heart failure and reduced left-ventricular (LV) systolic function. However, these medications can cause a rise in serum creatinine and their benefits in patients with HF accompanied by kidney disease are less certain. OBJECTIVE: To characterize associations between estimated glomerular filtration rate (eGFR), patterns of ACE-Is and ARBs use, and 1-year survival following hospitalization for heart failure (HF). DESIGN: We formed a retrospective cohort study of patients admitted with HF and followed HF medication prescriptions using the pharmaceutical information network, stratified by discharge eGFR. SETTING: Cardiology services in 3 centers in Southern Alberta, Canada. PATIENTS: The study cohort included patients admitted to hospital with a clinical diagnosis of HF. MEASUREMENTS: eGFR was determined from inpatient laboratory data prior to discharge. Outpatient prescription data prior to and following the index hospitalization was obtained using the Pharmaceutical Information Network of Alberta and survival was determined from provincial vital statistics. METHODS: Characteristics of the HF cohort were obtained from the Admissions Module of the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) database. Multivariable Cox proportional hazards models were used to evaluate the association between time-varying ACE-I/ARB use, and mortality, and to test whether eGFR modified this association. RESULTS: Totally, 1404 patients were included. Within the first 3 months following discharge, ACE-I/ARBs were used in 71%, 67%, 62%, and 52% for those with eGFR > 90, 45-89, 30-44, and < 30 mL/min/1.73 m2, respectively, with differences in use persisting after 1 year of follow-up. Patients with eGFR < 45 mL/min/1.73 m2 had significantly lower rates of ACE-I/ARB use following hospitalization. In adjusted models, ACE-I/ARB use following discharge was associated with 25% lower risk of mortality (Hazard Ratio [HR]: 0.75, 95% confidence interval [CI]: 0.61-0.92; P < 0.01), without evidence that this association differed by eGFR (P = 0.75). LIMITATIONS: LV function measurements were not available for the cohort. Due to the observation design of the study, treatment-selection bias may be present. CONCLUSION: Patients with HF and reduced eGFR at time of hospital discharge were less likely to receive ACE-I/ARB despite these medications being associated with lower mortality independent of eGFR. These findings demonstrate the need for further research on strategies for safe use of ACE-I and ARB in patients with HF and kidney disease.

CONTEXTE: Les inhibiteurs de l'enzyme de conversion de l'angiotensine (IECA) et les antagonistes des récepteurs de l'angiotensine (ARA) améliorent les résultats des patients atteints d'insuffisance cardiaque (IC) et d'une fonction systolique réduite du ventricule gauche. Ces médicaments peuvent cependant provoquer une hausse de la créatinine sérique et leurs bienfaits pour les patients atteints d'IC et de néphropathie sont plus incertains. OBJECTIF: L'étude visait à caractériser l'association entre le débit de filtration glomérulaire estimé (DFGe), les schémas d'utilisation des IECA/ARA, et la survie sur un an à la suite d'une hospitalisation pour IC. CONCEPTION DE L'ÉTUDE: Nous avons procédé à une étude de cohorte rétrospective à partir des données du réseau d'information pharmaceutique. La cohorte était constituée de patients admis pour IC et ayant suivi un traitement pour cette affection. La cohorte a été stratifiée sur la base du DFGe des patients à leur sortie de l'hôpital. CADRE: Le département de cardiologie de trois centres hospitaliers du sud de l'Alberta (Canada). SUJETS: La cohorte était constituée de patients admis à la suite d'un diagnostic d'IC. MESURES: Le DFGe a été déterminé en consultant les résultats de laboratoire des patients hospitalisés avant leur départ. L'information sur les prescriptions avant et après l'hospitalisation a été obtenue grâce au réseau d'information pharmaceutique de l'Alberta, et le taux de survie a été déterminé à l'aide des statistiques de vie de la province. MÉTHODOLOGIE: Les caractéristiques des patients ont été obtenues grâce au module d'admission de la base de données APPROACH (Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease). Des modèles multivariés des risques proportionnels de Cox ont été employés pour évaluer l'association entre l'utilisation variable des IECA/ARA dans le temps et le taux de mortalité; de même que pour vérifier si le DFGe avait une incidence sur cette association. RÉSULTATS: Au total, 1404 patients ont été inclus à l'étude. Dans les trois mois suivant l'hospitalisation, les taux de prescriptions des IECA/ARA variaient entre les différentes strates de DFGe de la cohorte et s'établissaient à 71% (DFGe > 90 mL/min/1.73 m2), 67% (DFGe entre 45 et 89 mL/min/1.73 m2), 62% (DFGe entre 30 et 44 mL/min/1.73 m2), et 52% (DFGe < 30 mL/min/1.73 m2); et ces différences ont persisté après un an de suivi. Les patients dont le DFGe était inférieur à 45 mL/min/1.73 m2 présentaient des taux d'utilisation des IECA/ARA significativement inférieurs après leur séjour à l'hôpital. Dans les modèles ajustés, l'utilisation des IECA/ARA à la sortie de l'hôpital a été associée à un risque inférieur de 25% de la mortalité (RR: 0.75; IC 95%: 0.61-0.92; P < .01), sans preuve que cette association diffère selon le DFGe (P = .75). LIMITES: Les mesures de la fonction ventriculaire gauche n'étaient pas disponibles pour la cohorte. De plus, en raison de sa nature observationnelle, l'étude pourrait comporter des biais relatifs au choix du traitement. CONCLUSION: Les patients atteints d'IC et dont le DFGe était faible au moment du congé étaient moins susceptibles de se voir prescrire des IECA/ARA, bien que ces médicaments soient associés à de plus faibles taux de mortalité indépendamment de la valeur du DFGe. Ces résultats démontrent la nécessité de poursuivre la recherche de stratégies permettant une utilisation sûre des IECA/ARA chez les patients atteints de néphropathie et d'insuffisance cardiaque.

Using residential proximity to wind turbines as an alternative exposure measure to investigate the association between wind turbines and human health.

This analysis uses data from the Community Noise and Health Study developed by Statistics Canada to investigate the association between residential proximity to wind turbines and health-related outcomes in a dataset that also provides objective measures of wind turbine noise. The findings indicate that residential proximity to wind turbines is correlated with annoyance and health-related quality of life measures. These associations differ in some respects from associations with noise measurements. Results can be used to support discussions between communities and wind-turbine developers regarding potential health effects of wind turbines.

Impact of Operator Positioning on Musculoskeletal Disorders and Work Habits Among Mississippi Dental Hygienists.

Purpose: The purpose of this study was to assess impact of operator positioning on the development of musculoskeletal disorders (MSDs) and workforce issues among practicing dental hygienists in the state of Mississippi.Methods: The sample consisted of all dental hygienists (n=1,553) licensed in the state of Mississippi. A modified 47 item, online version of the Standardized Nordic Questionnaire was used to document the following: types of MSDs, practice history, operator positioning, ergonomic work habits and the impact of MSDs on workforce issues. Descriptive statistics were used to analyze practice history and work habits. Chi-square analysis examined the relationship between operator positioning and MSDs as well as the relationship between the onset of MSDs and their impact on patient workload, work hours, time off from work, and ability to practice clinical dental hygiene. Survival analyses were used to test the onset of MSDs in relationship to operator positioning.Results: The survey yielded a 22% (n=338) response rate. There was no significant difference in the prevalence of MSDs between those sitting in front of the patient as compared to those sitting behind the patient (PL) (χ2 (1) = 1.67, p=0.196), although respondents sitting behind the patient reported developing their MSDs earlier (χ2 (1) = 3.92, p=0.048). Of the participants who had practiced 15 or more years, 85% reported developing MSDs. However, only 13% reported ever having to modify their patient load. Sixteen percent reported reducing work hours and 21% reported taking time off from work due to MSDs.Conclusions: Regardless of the operator position used, the majority of practicing dental hygienists surveyed developed MSDs earlier than has been previously reported in the literature. Workforce related issues were not shown to have a negative impact on this study population.

NLRP3 Localizes to the Tubular Epithelium in Human Kidney and Correlates With Outcome in IgA Nephropathy.

Nod-like receptor pyrin domain-containing-3 (NLRP3) has been implicated in the pathogenesis of experimental renal injury, yet its characterization in human kidney disease remains largely unexplored. NLRP3 expression was evaluated in human kidney biopsies, primary renal tubular cells (HPTC) and correlated to disease outcomes in patients with IgA nephropathy (IgAN). NLRP3 localized to renal tubules in normal human kidney tissue and to mitochondria within HPTC by immunohistochemistry and immunofluorescence microscopy. Compared to control kidneys, NLRP3 gene expression was increased in biopsies of patients with IgAN. While NLRP3 expression in IgAN was detected in glomeruli, it remained largely confined to the tubular epithelial compartment. In vitro NLRP3 mRNA and protein expression were transiently induced in HPTC by TGF-ß1 but subsequently diminished over time as cells lost their epithelial phenotype in a process regulated by transcription and ubiquitin-mediated degradation. Consistent with the in vitro data, low NLRP3 mRNA expression in kidney biopsies was associated with a linear trend of higher risk of composite endpoint of doubling serum creatinine and end stage renal disease in patients with IgAN. Taken together, these data show that NLRP3 is primarily a kidney tubule-expressed protein that decreases in abundance in progressive IgAN.

Guidelines for Classification of Acute Kidney Diseases and Disorders.

Recent efforts have standardized definitions and classification systems for acute kidney injury (AKI) and chronic kidney disease (CKD). These efforts have enhanced communication, recognition, and awareness of acute and CKDs and stimulated research on both disorders. However, abnormalities of kidney function and structure can occur that do not meet the current criteria for either disorder. Recognizing the need for a uniform approach encompassing both acute and chronic abnormalities of kidney function and structure, the Kidney Disease Improving Global Outcomes 2012 Clinical Practice Guideline for AKI Guidelines proposed an operational definition for acute kidney diseases and disorders (AKD) that encompasses both AKI and any newly recognized kidney disease that does not meet the current definitions for AKI or CKD. Recent commentaries have highlighted that it may be premature to adopt these criteria into clinical practice, but that they may be useful for application in epidemiologic studies. Future research is needed to better understand the clinical characteristics, incidence, and prognosis of AKD, as well as the implications of case identification based on the AKD criteria.

A modified Delphi process to identify process of care indicators for the identification, prevention and management of acute kidney injury after major surgery.

BACKGROUND: The outcomes of acute kidney injury (AKI) are well appreciated. However, valid indicators of high quality processes of care for AKI after major surgery are lacking. OBJECTIVES: To identify indicators of high quality processes of care related to AKI prevention, identification, and management after major surgery. DESIGN: A three stage modified Delphi process. SETTING: The study was conducted in Alberta, Canada using an online format. PARTICIPANTS: A panel of care providers from surgery, critical care, and nephrology. MEASUREMENTS: The degree of validity of candidate indicators were rated by panelists on a 7-point Likert scale that ranged from "strongly disagree" to "strongly agree". METHODS: A focused literature review was performed to identify candidate indicators. A modified Delphi process, with three rounds, was used to obtain expert consensus on the validity of potential process of care quality indicators. RESULTS: Thirty-three physicians participated (6 from surgery, 10 from critical care, and 17 from nephrology). A list of 58 potential process of care quality indicators for AKI after surgery was generated including 28 indicators from the initial literature review and 30 indicators suggested by panelists. Following the third round of questioning, 40 process of care indicators were identified with a high level of agreement for face validity; 16 of these reached high consensus among all panelists. LIMITATIONS: The consensus of panelists from Alberta, Canada may not be generalizable to other settings. The modified Delphi process did not focus on the feasibility of measuring these process indicators. CONCLUSIONS: These indicators can be used to measure and improve the quality of care for AKI after major surgery.

CONTEXTE: Les répercussions engendrées par l'insuffisance rénale aiguë (IRA) sont bien connues. Cependant, il n'existe toujours pas d'indicateurs de la qualité du processus de soin de l'IRA valides en phase postopératoire. OBJECTIFS DE L'ÉTUDE: Élaborer des indicateurs de la qualité des processus de soin en matière de prévention, d'identification et de prise en charge de l'IRA en phase postopératoire d'une chirurgie majeure. TYPE D'ÉTUDE: Processus Delphi modifié à trois étapes. LIEU DE L'ÉTUDE: L'étude a été effectuée en Alberta, Canada, par l'intermédiaire de questionnaires en ligne. PARTICIPANTS: Panel de professionnels de la santé des milieux suivants : chirurgie, soins intensifs et néphrologie. MESURES: Les panelistes ont évalué le degré de validité des indicateurs potentiels avec une échelle de Likert à 7 éléments, dont l'étendue se situait entre « fortement en désaccord ¼ (valeur originale : strongly disagree) et « fortement en accord ¼ (valeur originale : strongly agree). MÉTHODE: Une revue de la littérature ciblée a été effectuée pour faire ressortir les indicateurs pertinents. Une version modifiée du processus Delphi, comprenant trois étapes, a été utilisée dans le but d'obtenir l'avis des experts sur la validité des indicateurs potentiels en matière de qualité des processus de soin. RÉSULTATS: Trente-trois médecins ont participé au panel (6 chirurgiens, 10 intensivistes et 17 néphrologues). Une liste de 58 indicateurs potentiels de la qualité des processus de soin pour l'IRA en période postopératoire a été élaborée; celle-ci comprenait 28 indicateurs qui provenaient de la revue de la littérature et 30 qui avaient été suggérés par les panelistes. Après la troisième ronde de questionnaires, 40 indicateurs des processus de soins avaient été retenus pour leur validité apparente, avec un haut niveau d'accord parmi le panel, et 16 de ces indicateurs avaient atteint un fort consensus. LIMITES DE L'ÉTUDE: Le consensus qui provient du panel formé en Alberta, Canada, n'est peut-être pas généralisable à d'autres contextes. Le processus Delphi modifié ne s'est pas penché sur la faisabilité de la mesure des indicateurs de processus de soin. CONCLUSION: Ces indicateurs peuvent être utilisés pour mesurer et améliorer la qualité des soins de l'IRA en période postopératoire d'une chirurgie majeure.

The role of farm operational and rural environments as potential risk factors for pediatric asthma in rural Saskatchewan.

BACKGROUND: Researchers have historically reported that farm children have a lower prevalence of asthma compared to more urban children. Potential explanations include theories surrounding differences in personal factors, access to health care, engagement in health risk behaviors, and differences in the environment. OBJECTIVE: The aims of this study were to: (1) confirm whether the prevalence of asthma varies between farm and small town status among children living in Saskatchewan; (2) identify risk and protective factors for asthma, and use this information to infer which of the above theories is most explanatory for any observed geographic variations in pediatric asthma. METHODS: Rural students (N = 2383, 42% participation rate) from the province of Saskatchewan participated in a 2011 cross-sectional study. Parents completed a survey that included questions about location of residence, respiratory symptoms, potential risk factors for respiratory disease, and exposures to farm activities. Multiple logistic regression was used to examine relations between respiratory outcomes (asthma, wheeze) with farm type and farm activities, while accounting for factors that may underlie such relations. RESULTS: Asthma and wheeze prevalence did not differ by residential status. Living on a grain farm (OR = 0.64, 95% CI = 0.43-0.96), cleaning or playing in pens (OR = 0.69, 95% CI = 0.46-1.02), filling grain bins (OR = 0.56, 95% CI = 0.32-0.96), and riding horses (OR = 0.65, 95% CI = 0.40-1.05) were protective factors for ever diagnosis with asthma. CONCLUSIONS: We identified a number of risk and protective factors for asthma and associated wheeze. This suggests the need to focus on specific environmental explanations to better understand previously observed associations between farm residential status and asthma.

Improving prevention, early recognition and management of acute kidney injury after major surgery: results of a planning meeting with multidisciplinary stakeholders.

PURPOSE OF REVIEW: Acute kidney injury (AKI) is common after major surgery, and is associated with morbidity, mortality, increased length of hospital stay, and high health care costs. Although recent guidelines for AKI provide recommendations for identification of patients at risk, monitoring, diagnosis, and management of AKI, there is lack of understanding to guide successful implementation of these recommendations into clinical practice. SOURCES OF INFORMATION: We held a planning meeting with multidisciplinary stakeholders to identify barriers, facilitators, and strategies to implement recommendations for prevention, early identification, and management of AKI after major surgery. Barriers and facilitators to knowledge use for peri-operative AKI prevention and care were discussed. FINDINGS: Stakeholders identified barriers in knowledge (how to identify high-risk patients, what criteria to use for diagnosis of AKI), attitudes (self-efficacy in preventive care and management of AKI), and behaviors (common use of diuretics, non-steroidal anti-inflammatory drugs, withholding of intravenous fluids, and competing time demands in peri-operative care). Educational, informatics, and organizational interventions were identified by stakeholders as potentially useful elements for future interventions for peri-operative AKI. LIMITATION: Meeting participants were from a single centre. IMPLICATIONS: The information and recommendations obtained from this stakeholder's meeting will be useful to design interventions to improve prevention and early care for AKI after major surgery.

OBJECTIF DE L'ÉTUDE: L'insuffisance rénale aiguë (IRA) est fréquente à la suite d'une chirurgie importante et elle est associée à une morbidité, à une mortalité, à une hospitalisation prolongée et à des coûts élevés liés aux soins de santé. Bien que les lignes directrices récentes concernant l'IRA fournissent des recommandations pour déterminer les patients à risque, de même que pour contrôler, diagnostiquer et prendre en charge l'IRA, la compréhension fait défaut pour mener leur mise en place réussie dans la pratique clinique. SOURCES D'INFORMATION: Nous avons tenu une réunion de planification avec des acteurs pluridisciplinaires afin de cibler les obstacles, les appuis et les stratégies de mise en œuvre des recommandations pour la prévention, l'identification précoce et la prise en charge de l'IRA suite à une chirurgie importante. On a abordé les obstacles et les appuis à l'utilisation des connaissances dans la prévention périopératoire de l'IRA et les soins qui s'y rattachent. RÉSULTATS: Les acteurs ont déterminé les obstacles à la connaissance (comment identifier les patients à risque élevé, le choix de critères diagnostiques pour l'IRA), les attitudes (l'auto-efficacité dans les soins préventifs et la prise en charge de l'IRA), et les comportements (l'usage courant de diurétiques, d'anti-inflammatoires non stéroïdiens, la non-administration de solutés intraveineux, et les contraintes de temps dans les soins périopératoires). Les acteurs ont défini les interventions éducatives, informatiques et organisationnelles comme des éléments potentiellement utiles dans les interventions futures en soins périopératoires pour l'IRA. LIMITES DE L'ÉTUDE: Les participants à la réunion provenaient d'un seul et même centre. IMPACTS: Les informations et recommandations obtenues au cours de la réunion des acteurs seront utiles pour l'élaboration des interventions afin d'améliorer la prévention et les soins précoces relatifs à l'IRA suite à une chirurgie majeure.