RESUMO
The Georgian Mountain Cattle (GMC) (Species: Bos taurus Linnaeus, 1758 - aurochs, domesticated cattle, domestic cattle (feral), Aurochs, Subspecies: Bos taurus taurus Linnaeus, 1758) is a local breed from Georgia. It is well adapted to the harsh mountain conditions of the Caucasus, resistant to different pathogens and able to provide milk during the lowest feed rations. In this study, we report for the first time the complete mitochondrial genome sequence of GMC. We selected the five unique control region mitochondrial haplotypes of GMC and sequenced for the complete mitogenome, using Illumina MiSeq platform. The results of our research showed a total of 59 substitutions and seven indels, in comparison to the Bovine Reference Sequence (BRS; V00654), with 15 SNPs never observed before. The complete mitochondrial DNA (mtDNA) phylogenetic analyses revealed hitherto unknown haplotypes falling outside the known taurine diversity. Four mitogenomes fell within haplogroup T (sub-lineages T1, T3, and T5), while one belonged to haplogroup Q (branch Q1). The combination of our results with precision agriculture holds great promises for the identification of genetic variants economically affecting important traits of GMC cattle.
RESUMO
The treatment of intracranial saccular aneurysms remains an actual problem due to this pathology prevalence among the human population (about 1-10%). For definition of efficiency and preventive importance of endovascular treatment, it is necessary to clear define which aneurysms are more suitable and operable for endovascular occlusion with minimal risk of complications and better final outcome. The aim of this study is to analyze anatomical features (location and structure) of intracranial saccular aneurysms and clinical data of patients who have been operated endovascular, with detachable coils in High Technology Medical Center University Clinic,Tbilisi, Georgia for the last 6 years. The study included 412 patients with 470 aneurysms who were operated from 2011 to 2016 using detachable coils. The age of patients ranged from 8 to 78 years. The largest number of patients belonged to the age group - 32-55 years. The men were 196 (47.6%), women - 216 (52.4%). In acute period 280 (68%) patients were operated, in the delayded period - 90 (21.8%), unruptured aneurysms - 42 (10.2%). Early results and outcomes (1-3 week) after endovascular treatment of SA were estimated with GOS. Full Recovery or Low disability was achieved in 313(76%) patient- GOS 5, Moderate disability in 48(11.7) patient- GOS 4 , Severe disability or Persistent vegetative state in 44(10.6%) patient- GOS 3-2 and GOS 1-death in 7(1.7%) patient. According to the study it can be concluded that endovascular treatment is a reliable, low-impact and effective way to treat the Saccular brain aneurysm. Despite the variety of aneurysm these treatments are optimistic and affirm the importance of endovascular treatment of cerebral aneurysms.