1.
J Org Chem
; 74(5): 2207-9, 2009 Mar 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19245267
RESUMO
A scalable procedure for the conversion of nitriles to N-tert-butyl amides via the Ritter reaction was optimized employing tert-butyl acetate and acetic acid. The reaction has a broad scope for aromatic, alkyl, and alpha,beta-unsaturated nitriles.