Self-compassion as a mediator of the relationship between childhood sexual abuse and psychotic symptoms in clinical and non-clinical groups.

BACKGROUND: Previous research has shown a link between childhood sexual abuse (CSA) and more severe symptoms of psychosis. There is also evidence that self-compassion is a key mechanism linking adverse childhood experiences and mental health problems such as post-traumatic stress disorder and depression, but no research has examined these links in psychosis. METHODS: We analysed existing cross-sectional data, including 55 individuals with psychosis and 166 individuals from the general population. Participants completed standardized measures of CSA, self-compassion, paranoia, positive psychotic symptoms and distress linked to psychosis. RESULTS: The clinical group had higher scores on CSA and all psychosis measures, but we found no differences in self-compassion between the groups. Higher levels of CSA correlated with lower self-compassion and higher paranoia and positive symptoms in both groups. CSA also correlated with distress linked to psychosis in the non-clinical group. Lower self-compassion mediated the association between higher levels of CSA and more severe paranoia in both groups. In the non-clinical group, lower self-compassion also mediated the association between greater CSA and more positive psychotic symptoms and more severe distress. CONCLUSIONS: This is the first study to show that self-compassion mediates the link between CSA and both paranoia and psychotic symptoms in adulthood. Self-compassion may therefore be an important transdiagnostic candidate target in therapy to mitigate the impact of early adversity on paranoia in both clinical and non-clinical groups. Limitations include the small clinical sample and inclusion of a cannabis-using non-clinical sample, though recent cannabis use did not impact self-compassion levels.

Carbon Nanotube and Cellulose Nanocrystal Hybrid Films.

The use of cellulose nanocrystals (CNC) in high performance coatings is attractive for micro-scale structures or device fabrication due to the anisotropic geometry, however CNC are insulating materials. Carbon nanotubes (CNT) are also rod-shaped nanomaterials that display high mechanical strength and electrical conductivity. The hydrophobic regions of surface-modified CNC can interact with hydrophobic CNT and aid in association between the two anisotropic nanomaterials. The long-range electrostatic repulsion of CNC plays a role in forming a stable CNT and CNC mixture dispersion in water, which is integral to forming a uniform hybrid film. At concentrations favorable for film formation, the multiwalled nanotubes + CNC mixture dispersion shows cellular network formation, indicating local phase separation, while the single-walled nanotube + CNC mixture dispersion shows schlieren texture, indicating liquid crystal mixture formation. Conductive CNT + CNC hybrid films (5-20 µm thick) were cast on glass microscope slides with and without shear by blade coating. The CNT + CNC hybrid films electrical conductivity increased with increasing CNT loadings and some anisotropy was observed with the sheared hybrid films, although to a lesser extent than what was anticipated. Percolation models were applied to model the hybrid film conductivity and correlate with the hybrid film microstructure.

Experiences of antidepressant medication and cognitive-behavioural therapy for depression: a grounded theory study.

OBJECTIVES: To develop a preliminary model of the experiences of people undergoing combined treatment with antidepressant medication and cognitive-behavioural therapy (CBT) for depression. DESIGN: The study used a qualitative methodology informed by grounded theory. METHODS: Participants were 12 adults who had received treatment with antidepressant medication and CBT for depression. Participants engaged in a semistructured interview about their experiences. Interviews were transcribed and analysed using components of grounded theory methodology. RESULTS: Medication was often seen as an initial aid to surviving a crisis. Staying on medication longer term resulted in some participants feeling caught in a 'drug loop'. Feeling that medication was unhelpful or actively harmful could contribute to participants seeking CBT. Medics also offered information on CBT and acted as gatekeepers, meaning that negotiation was sometimes necessary. CBT was described as a process of being guided towards skilled self-management. Occasionally, participants felt that medication had facilitated CBT at one or more stages. Conversely, developing skilled self-management through CBT could reduce feelings of dependency on medication and affect several of the other elements maintaining the 'drug loop'. CONCLUSIONS: Antidepressant medication and CBT are perceived and experienced differently, with CBT often being seen as an alternative to medication, or even as a means to discontinue medication. Service users' experiences and beliefs about medication may thus affect their engagement and goals in CBT, and it may be important for therapists to consider this. PRACTITIONER POINTS: Practitioners who prescribe medication should ensure that they also provide information on the availability and appropriateness of CBT, and engage in an open dialogue about treatment options. CBT practitioners should explore aspects of clients' experiences and beliefs about medication. This would particularly include clients' experiences of the effects of medication, their beliefs about dependency on medication, their relationships with prescribers, and their future wishes. Practitioners should consider advocating for clients or supporting them to behave more assertively with prescribers. All practitioners should ensure they have up-to-date knowledge of antidepressant medication.

Thomas Prosser (c1780-1827): army surgeon on the convict ship Maria.

Between 1793 and 1815, The French Wars between Britain and France provided work for a generation of army surgeons. Military efficiency in record keeping and subsequent governmental archiving ensured that material is available for the biographers of such men. However, by contrast information on these surgeons while in civilian practice is scant. Thomas Prosser is a typical example of a well-qualified early 19th century surgeon who chose a career with the army and who, while on half pay, was surgeon to a female convict ship.