Next generation high resolution perovskite direct conversion detector: Monte Carlo design optimisation and virtual clinical trial.

We implement virtual clinical integration of next-generation perovskite detectors into common x-ray imaging devices. This was achieved by performing Monte Carlo (MC) optimisation of the design and benchmarking of low cost, high spatial resolution, direct conversion perovskite crystal x-ray flat panel imagers for a next generation of breast-, MV-, and kV-cone beam CT detectors. Semiconductor methylammonium lead bromide perovskite crystals energy deposition efficiencies calculated in TOPAS were benchmarked against four common detector materials for twelve detector crystal thicknesses between 40 to 15 mm and ten beam energies ranging from 20 keV to 6 MeV. Based on these simulations, Koning's dedicated breast CT, and Varian's Truebeam kV- and MV-cone beam CT systems were designated as suitable applications for perovskite detectors. System specific Fastcat hybrid MC cone beam CT image simulation was subsequently used to optimise the perovskite detector design and conduct virtual clinical trials. Device-specific optimal perovskite crystal thicknesses were calculated to be 0.30, 0.86, and 1.99 mm for Koning breast CT and Truebeam kV- and MV-cone beam CT systems, respectively. Replacing the current detectors on these machines with low cost perovskite crystal detectors could be advantageous as it would simultaneously yield 12.1%, 9.5% and 86.1% improvements in detective quantum efficiency as well as increases in contrast to noise ratio in brain, lung, and bone tissues.

Optimization of radiochromic film stacks to diagnose high-flux laser-accelerated proton beams.

Here, we extend flatbed scanner calibrations of GafChromic EBT3, MD-V3, and HD-V2 radiochromic films using high-precision x-ray irradiation and monoenergetic proton bombardment. By computing a visibility parameter based on fractional errors, optimal dose ranges and transitions between film types are identified. The visibility analysis is used to design an ideal radiochromic film stack for the proton energy spectrum expected from the interaction of a petawatt laser with a cryogenic hydrogen jet target.

Investigation of combined kV/MV CBCT imaging with a high-DQE MV detector.

PURPOSE: Combined kV-MV cone-beam tomography (CBCT) imaging has been proposed for two potentially important image-guided radiotherapy applications: (a) scan time reduction (STR) and (b) metal artifact reduction (MAR). However, the feasibility of these techniques has been in question due to the low detective quantum efficiencies (DQEs) of commercially available electronic portal imagers (EPIDs). The goal of the work was to test whether a prototype high DQE MV detector can be used to generate acceptable quality pretreatment CBCT images at acceptable dose levels. METHODS: 6MV and 100 kVp projection data were acquired on a Truebeam system (Varian, Palo Alto, CA). The MV data were acquired using a prototype EPID containing two scintillators (a) a standard copper-gadolinium oxysulfide (Cu-GOS) screen having a zero-frequency DQE (DQE(0)) value of 1.4%, and (b) a prototype-focused cadmium tungstate (CWO) pixelated "strip" with a DQE(0) = 22%. The kV data were acquired using the standard onboard imager (DQE(0) = 70%). The angular spacing of the MV projections was 0.81° and the source output was 0.03 MU/projection while the kV projections were acquired with an angular spacing of 0.4° at 0.3 mAs/projection. Image quality was evaluated using (a) an 18-cm diameter electron density phantom (CIRS, Norfolk, VA) with nine contrast inserts and (b) the resolution section of the 20-cm diameter Catphan phantom (The Phantom Laboratory, Greenwich, NY). For the MAR studies, two opposing CIRS phantom inserts were replaced by steel rods. The reconstruction methods were based on combining MV and kV data into one sinogram. The MAR reconstruction utilized mostly kV raw data with only those rays corrupted by metal requiring replacement with MV data (total absorbed dose = 0.7 cGy). For the STR study, projections from partially overlapping 105°kV and MV acquisitions were combined to create a complete dataset that could have been acquired in 18 sec (absorbed dose = 2.5 cGy). MV-only (4.3 cGy) and kV-only (0.3 cGy) images were also reconstructed. RESULTS: The average signal-to-noise ratio (SNR) of the inserts in the MV-only CWO and GOS CIRS phantom images were 0.62× and 0.12× the SNR of the inserts in kV-only image, respectively. The limiting spatial resolutions in the MV-only GOS, MV-only CWO, and kV-only Catphan images were 3, 6, and 8 lp/cm, respectively. In the combined kV/CWO STR reconstruction, all contrast inserts were visible while only two were detectable in the kV/Cu-GOS image due to high levels of noise (average SNRs of kV/CWO and kV/GOS inserts were 0.97× and 0.18× the SNR of the kV-only inserts, respectively). In the kV-MV MAR reconstructions, streaking artifacts were substantially reduced with all inserts becoming clearly visible in the kV/CWO image while only two were visible in the kV/Cu-GOS image (average SNRs of the kV/CWO and kV/Cu-GOS CIRS with metal inserts were 0.94× and 0.35× the SNRs of the kV-only CIRS without metal inserts). CONCLUSIONS: We have demonstrated that a high-DQE MV detector can be applied to generating high-quality combined kV-MV images for SRT and MAR. Clinically acceptable doses were utilized.

Optimization of a table-top x-ray fluorescence computed tomography (XFCT) system.

Pencil beam x-ray fluorescence computed tomography (XFCT) has typically used a single spectrometer and prohibitively long scan times. However, detecting backscattered fluorescent x-rays from gold nanoparticles (AuNPs) using multiple spectrometers greatly reduces image noise and scan time. The arrangement of eight spectrometers for combined K-shell and L-shell XFCT was investigated along with a variety of conditions. A 2.5 cm-diameter cylindrical water phantom containing 4 mm-diameter vials with 0.1%-2% AuNP concentrations by weight was modeled by TOPAS, a GEANT4-based Monte Carlo software. The phantom was irradiated to 30 mGy by a 0.5 mm Pb-filtered 120 kVp and 1 mm Al-filtered 30 kVp 1 mm2 x-ray pencil beam to yield respective Au K-shell and L-shell fluorescent x-rays, with 50 0.5 mm translation and 2-degree rotation steps. Eight CdTe and silicon drift detector (SDD) spectrometers were placed 2.25 cm away from the isocentre. The respective energy resolution was applied to the detected energy spectra and the spectra were corrected for detector response before extracting the fluorescence signal. Three CdTe and SDD spectrometer configurations (isotropic/backscattered grid/backscattered row arrangements), two CdTe crystal sizes (9 mm2/25 mm2), two scanning techniques (moving/stationary spectrometers) and five vial-edge depths (0-4 mm) were considered in optimizing the contrast-to-noise ratio (CNR) for each XFCT image reconstructed with a maximum-likelihood expectation maximization (MLEM) algorithm. The isotropic spectrometer arrangement had AuNP detection sensitivities of 0.106% for K-shell and 0.132% for L-shell XFCT at 4 mm depth. Comparatively, the backscattered grid arrangement had the best AuNP sensitivity of 0.055% and 0.095%. The highest K-shell (0.044%) and L-shell (0.004%) AuNP sensitivities were found for vials at 0 mm depth. Using stationary spectrometers or the 9 mm2 CdTe crystal compromised the CNR. For the best-case arrangement, L-shell XFCT is superior at vial-edge depths less than 3.0 mm. This work demonstrated the importance of spectrometer arrangement and vial depth for improving AuNP sensitivity and will guide the design for our table-top XFCT system.

Development of a high resolution voxelised head phantom for medical physics applications.

Computational anthropomorphic phantoms have become an important investigation tool for medical imaging and dosimetry for radiotherapy and radiation protection. The development of computational phantoms with realistic anatomical features contribute significantly to the development of novel methods in medical physics. For many applications, it is desirable that such computational phantoms have a real-world physical counterpart in order to verify the obtained results. In this work, we report the development of a voxelised phantom, the HIGH_RES_HEAD, modelling a paediatric head based on the commercial phantom 715-HN (CIRS). HIGH_RES_HEAD is unique for its anatomical details and high spatial resolution (0.18×0.18mm2 pixel size). The development of such a phantom was required to investigate the performance of a new proton computed tomography (pCT) system, in terms of detector technology and image reconstruction algorithms. The HIGH_RES_HEAD was used in an ad-hoc Geant4 simulation modelling the pCT system. The simulation application was previously validated with respect to experimental results. When compared to a standard spatial resolution voxelised phantom of the same paediatric head, it was shown that in pCT reconstruction studies, the use of the HIGH_RES_HEAD translates into a reduction from 2% to 0.7% of the average relative stopping power difference between experimental and simulated results thus improving the overall quality of the head phantom simulation. The HIGH_RES_HEAD can also be used for other medical physics applications such as treatment planning studies. A second version of the voxelised phantom was created that contains a prototypic base of skull tumour and surrounding organs at risk.

Absolute dosimetric characterization of Gafchromic EBT3 and HDv2 films using commercial flat-bed scanners and evaluation of the scanner response function variability.

Radiochromic films (RCF) are commonly used in dosimetry for a wide range of radiation sources (electrons, protons, and photons) for medical, industrial, and scientific applications. They are multi-layered, which includes plastic substrate layers and sensitive layers that incorporate a radiation-sensitive dye. Quantitative dose can be retrieved by digitizing the film, provided that a prior calibration exists. Here, to calibrate the newly developed EBT3 and HDv2 RCFs from Gafchromic™, we used the Stanford Medical LINAC to deposit in the films various doses of 10 MeV photons, and by scanning the films using three independent EPSON Precision 2450 scanners, three independent EPSON V750 scanners, and two independent EPSON 11000XL scanners. The films were scanned in separate RGB channels, as well as in black and white, and film orientation was varied. We found that the green channel of the RGB scan and the grayscale channel are in fact quite consistent over the different models of the scanner, although this comes at the cost of a reduction in sensitivity (by a factor ∼2.5 compared to the red channel). To allow any user to extend the absolute calibration reported here to any other scanner, we furthermore provide a calibration curve of the EPSON 2450 scanner based on absolutely calibrated, commercially available, optical density filters.