Prevalence of vulvovaginal candidiasis in pregnancy at three health centers in Burkina Faso.

INTRODUCTION: Pregnant women are more susceptible to vaginal colonization and infection by yeast. The role of Candida colonization in the occurrence of preterm birth is well established. The knowledge of local epidemiology and identification of risk factors for preterm birth is important for the prevention and management strategies. The purpose of the study was to determine the prevalence of Candida sp. in vaginal swabs of pregnant women. METHODS: Pregnant women attending routine antenatal visits in three primary health centres in Bobo-Dioulasso (Burkina Faso) were enrolled into a cross-sectional study carried out from February to April 2015. Vaginal swabs samples were taken from participants after obtaining oral consent. The swabs were inoculated into Sabouraud's glucose agar supplemented with chloramphenicol and incubated at 37°C for 24 to 48hours under aerobic conditions in order to perform fungal culture. The identification of the Candida species was done by culture on HiCrome Candida Differential Agar at 35°C for 48h for production of species-specific colors. RESULTS: A total of 229 pregnant women were included. The prevalence of vulvovaginal candidiasis (VVC) was 22.71%, (95% CI [17.45-28.69]). Candida albicans accounted for 40.39% and non-Candida albicans species for 59.61% of the isolates, with mainly C. glabrata (32.69%), C. tropicalis (15.38%) and C. krusei (11.54%). CONCLUSIONS: This study revealed a high prevalence of non-C. albicans species. The syndromic management guidelines for VVC in Burkina Faso will be revised to include a specific protocol for pregnant women.

[Hematologic malignancies in internal medicine, University Hospital of Souro Sanou (Burkina Faso)]. / Place des hemopathies malignes en service de medecine interne du CHU Souro Sanou (Burkina Faso).

INTRODUCTION: Hematologic malignancies (HM) in internal medicine remain undocumented, both epidemiological aspects, diagnosis, therapeutic that evolutionary. An inventory of sites, will document these aspects, to identify highly lethal forms, and thus contribute to improving the management of HM in a hospital in a developing country. MATERIAL AND METHODS: A cross-sectional retrospective study referred to descriptive over two and a half years, from review of patients' medical records allowed an exhaustive census of 58 cases of HM admitted to the Department of Internal Medicine of University Hospital Souro Sanou (UHC SS). RESULTS: The first reason for consultation were abdominal tumor syndrome (63.7%). The average age of patients was 42 ± 19.7 years with extremes ranging from 16 to 87 years. The sex ratio was 1.42: 1. Hematological disturbances were strongly suspected anemia (89.2%), leukocytosis (64.3%) and thrombocytopenia (46.4%). The HM depending on cytology were dominated by lymphomas (48.2%) followed by chronic myeloid leukemia or 15.5%. Chemotherapy was undertaken in 63.7% of cases. Lethality was 23.1%, was significantly higher for acute leukemia 40% (p = 0.0012). HIV serology was positive in 3 patients among the 13 cases tested. CONCLUSION: This study provided a better understanding of HM epidemiology at the UHC SS in the department of internal medicine. It revealed a predominance of lymphomas with difficulties in the initiation of chemotherapy. Improving access to chemotherapy, and technical support enable a reduction in the fatality associated with HM in the department of internal medicine at UHC SS.