Vitamin D levels and influencing predictors in refugee children in Sherbrooke (Quebec), Canada.

BACKGROUND AND OBJECTIVE: Suboptimal vitamin D levels and associated complications are on the rise. Vulnerable populations, like refugee children, are further at risk. Studies on the vitamin D levels in refugee children are limited. The primary objective of this cross-sectional retrospective study was to determine the level of serum 25-hydroxyvitamin D (25-(OH)D) in the paediatric refugee population residing in Sherbrooke, Quebec, Canada. The secondary objective was to determine variables predicting vitamin D levels. METHODS: Refugees under the age of 19 years arriving in Sherbrooke, Quebec, Canada, evaluated by the refugee clinic between March 2013 and April 2014, were included in the study. Vitamin D levels upon arrival and variables including age, sex, body mass index, season of arrival and season of test, ethnicity, previous country of residence and duration of stay in Canada from time of arrival were recorded. The protocol was approved by the scientific and ethics board of respective institutions. RESULTS: A total of 138 subjects were included in the study from the Middle East, Central Asia and South East Asia, Africa and South America. The mean 25-(OH)D serum value was 55 nmol/L (insufficient). Fourteen per cent of subjects were vitamin D deficient and 64% were vitamin D insufficient as per Canadian Paediatric Society threshold guidelines. Gender (P=0.022), age (P<0.001), latitude (P<0.001) and season of testing (P=0.022) predict vitamin D status. CONCLUSIONS: This study concluded that refugee children have insufficient vitamin D levels. Gender, age, latitude and season of testing have an impact in predicting vitamin D status.

Hypersensitivity reaction to parenteral nutrition in an intrauterine growth-restricted newborn: a case report.

Hypersensitivity reaction to parenteral nutrition (PN) in infants is a rare condition, especially in the neonatal period. The authors report the case of a neonate with intrauterine growth restriction (IUGR) who presented symptoms of anaphylaxis while receiving standard PN. Given the very common practice of neonatal PN use, especially in newborns with IUGR, clinicians should be alerted about possible acute reactions to this useful therapy.