[Agranulocytosis--a complication of the chemotherapy of echinococcosis with mebendazole]. / Agranulotsitoz--oslozhnenie khimioterapii ékhinokokkozov mebendazolom.

Only two of the 75 patients with echinococcosis, treated with mebendazole in a dose of 50 mg/kg b. m. for 30 days (single course) and administered from 1 to 13 courses with intervals of 1 to 3 months, developed agranulocytosis eventuating in death in one female patient. Analysis of blood levels of mebendazole and its metabolites permits a hypothesis that high concentrations thereof may have a toxic effect on the bone marrow, inducing its hypoplasia, in subjects sensitive to these substances.

[Diagnosis of opisthorchiasis using the membrane filtration technique]. / Diagnostika opistorkhoza metodom membrannoi fil'tratsii.

Filtration method for the detection of Opisthorchis eggs in the bile is by an order more sensitive than the routine method. It is recommended for diagnostic studies for cases with a low invasion level and in assessment of the efficacy of chemotherapeutic agents. This technique may be useful in the diagnosis of other helminthiases as well.

[An evaluation of methods for the quantitative determination of praziquantel as a substance]. / Otsenka metodov kolichestvennogo opredeleniia prazikvantelia v substantsii.

Feasibility of quantitative determination of a new helminthicide prasiquantel as a substance by spectral and chemical analytic procedures has been investigated. Chemical methods based on nitrogen measurement in the samples were shown to lack precision which is obligatory for drug analysis. The quantitative analytic procedures based on UV spectrophotometry are of low precision and selectivity. Infrared spectroscopy is the only method of prasiquantel assay that meets the requirements for drug substance measurement.