Assuntos
Endoscopia Gastrointestinal/tendências , Eosinofilia/diagnóstico , Esofagite/diagnóstico , Gastroenterologia/tendências , Gastroenteropatias , Neoplasias Pancreáticas/terapia , Gastroenteropatias/diagnóstico , Gastroenteropatias/terapia , Motilidade Gastrointestinal , Humanos , Doenças Inflamatórias Intestinais/diagnóstico , Doenças Inflamatórias Intestinais/terapiaAssuntos
Colangiopancreatografia Retrógrada Endoscópica/métodos , Cisto do Colédoco/diagnóstico , Cisto do Colédoco/cirurgia , Colestase/cirurgia , Pâncreas/anormalidades , Anormalidades Múltiplas/diagnóstico , Anormalidades Múltiplas/cirurgia , Adulto , Colestase/diagnóstico , Ducto Colédoco/diagnóstico por imagem , Ducto Colédoco/cirurgia , Anormalidades do Sistema Digestório/diagnóstico , Anormalidades do Sistema Digestório/cirurgia , Drenagem/métodos , Feminino , Seguimentos , Humanos , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Doenças Raras , Medição de Risco , Resultado do TratamentoRESUMO
Colorectal cancer that occurs during an interval between screening colonoscopies is called "interval carcinoma". These cancers are more frequent than would be expected, diagnosed in about tow per thousand patient years. There are three main causes for interval carcinomas: 50 % result from failed detection of polyps during colonoscopy, 25 % are tumors that develop during the screening interval and 25 % result from incomplete polypectomy. Knowing these etiologies screening makes it possible to optimize treatment. Colonoscopy of the highest quality is essential for providing reliable screening. Risk stratification during the first colonoscopy allows for optimal timing of follow-up-examinations. Difficult polypectomies require frequent follow-ups. Serrated adenomas should be treated like adenomas. Interval carcinomas are often detected during screening at an early stage: colonoscopy screening can save life of these patients.
Assuntos
Adenoma/diagnóstico , Pólipos do Colo/diagnóstico , Pólipos do Colo/cirurgia , Colonoscopia/normas , Neoplasias Colorretais/diagnóstico , Neoplasias Colorretais/etiologia , Adenoma/patologia , Adenoma/cirurgia , Pólipos do Colo/complicações , Neoplasias Colorretais/patologia , Humanos , Medição de Risco , Fatores de Risco , Fatores de TempoRESUMO
Treatment of organ donors with catecholamines reduces acute rejection episodes and improves long-term graft survival after renal transplantation. The aim of this study was to investigate the effect of catecholamine pre-treatment on ischemia/reperfusion (I/R)- and cold preservation injury in rat kidneys. I/R-injury was induced by clamping the left kidney vessels for 60 min along with a contralateral nephrectomy. Cold preservation injury was induced by storage of the kidneys for 24 h at +4 degrees Celsius in University of Wisconsin solution, followed by syngeneic transplantation. Rats were pre-treated with either dopamine (DA), dobutamine (DB), or norepinephrine (2, 5, and 10 microg/kg/min, each group) intravenously via an osmotic minipump for 24 h before I/R- and cold preservation injury. Pre-treatment with DA (2 or 5 microg/kg/min) and DB (5 microg/kg/min) improved recovery of renal function after I/R-injury and dose dependently reduced mononuclear and major histocompatibility complex class II-positive cells infiltrating the kidney after I/R-injury. One day after I/R-injury, upregulation of transforming growth factor (TGF)-beta 1 and 2 and phosphorylation of p42/p44 mitogen-activated protein kinases was observed in kidneys of animals treated with DA or DB. DA (5 microg/kg/min) and DB (5 microg/kg/min) pre-treatment reduced endothelial cell damage after 24 h of cold preservation. Only DA pre-treatment improved renal function and reduced renal inflammation after 24 h of cold preservation and syngeneic transplantation. Our results demonstrate a protective effect of pre-treatment with catecholamines on renal inflammation and function after I/R- or cold preservation injury. This could help to explain the potent organoprotective effects of catecholamine pre-treatment observed in human kidney transplantation.