Modeling Epistemic Uncertainty in Offshore Wind Farm Production Capacity to Reduce Risk.

Financial stakeholders in offshore wind farm projects require predictions of energy production capacity to better manage the risk associated with investment decisions prior to construction. Predictions for early operating life are particularly important due to the dual effects of cash flow discounting and the anticipated performance growth due to experiential learning. We develop a general marked point process model for the times to failure and restoration events of farm subassemblies to capture key uncertainties affecting performance. Sources of epistemic uncertainty are identified in design and manufacturing effectiveness. The model then captures the temporal effects of epistemic and aleatory uncertainties across subassemblies to predict the farm availability-informed relative capacity (maximum generating capacity given the technical state of the equipment). This performance measure enables technical performance uncertainties to be linked to the cost of energy generation. The general modeling approach is contextualized and illustrated for a prospective offshore wind farm. The production capacity uncertainties can be decomposed to assess the contribution of epistemic uncertainty allowing the value of gathering information to reduce risk to be examined.

Quantifying uncertainty about future antimicrobial resistance: Comparing structured expert judgment and statistical forecasting methods.

The increase of multidrug resistance and resistance to last-line antibiotics is a major global public health threat. Although surveillance programs provide useful current and historical information on the scale of the problem, the future emergence and spread of antibiotic resistance is uncertain, and quantifying this uncertainty is crucial for guiding decisions about investment in antibiotics and resistance control strategies. Mathematical and statistical models capable of projecting future rates are challenged by the paucity of data and the complexity of the emergence and spread of resistance, but experts have relevant knowledge. We use the Classical Model of structured expert judgment to elicit projections with uncertainty bounds of resistance rates through 2026 for nine pathogen-antibiotic pairs in four European countries and empirically validate the assessments against data on a set of calibration questions. The performance-weighted combination of experts in France, Spain, and the United Kingdom projected that resistance for five pairs on the World Health Organization's priority pathogens list (E. coli and K. pneumoniae resistant to third-generation cephalosporins and carbapenems and MRSA) would remain below 50% in 2026. In Italy, although upper bounds of 90% credible ranges exceed 50% resistance for some pairs, the medians suggest Italy will sustain or improve its current rates. We compare these expert projections to statistical forecasts based on historical data from the European Antimicrobial Resistance Surveillance Network (EARS-Net). Results from the statistical models differ from each other and from the judgmental forecasts in many cases. The judgmental forecasts include information from the experts about the impact of current and future shifts in infection control, antibiotic usage, and other factors that cannot be easily captured in statistical forecasts, demonstrating the potential of structured expert judgment as a tool for better understanding the uncertainty about future antibiotic resistance.

Investing in antibiotics to alleviate future catastrophic outcomes: What is the value of having an effective antibiotic to mitigate pandemic influenza?

Over 95% of post-mortem samples from the 1918 pandemic, which caused 50 to 100 million deaths, showed bacterial infection complications. The introduction of antibiotics in the 1940s has since reduced the risk of bacterial infections, but growing resistance to antibiotics could increase the toll from future influenza pandemics if secondary bacterial infections are as serious as in 1918, or even if they are less severe. We develop a valuation model of the option to withhold wide use of an antibiotic until significant outbreaks such as pandemic influenza or foodborne diseases are identified. Using real options theory, we derive conditions under which withholding wide use is beneficial, and calculate the option value for influenza pandemic scenarios that lead to secondary infections with a resistant Staphylococcus aureus strain. We find that the value of withholding an effective novel oral antibiotic can be positive and significant unless the pandemic is mild and causes few secondary infections with the resistant strain or if most patients can be treated intravenously. Although the option value is sensitive to parameter uncertainty, our results suggest that further analysis on a case-by-case basis could guide investment in novel agents as well as strategies on how to use them.

Sequential Refined Partitioning for Probabilistic Dependence Assessment.

Modeling dependence probabilistically is crucial for many applications in risk assessment and decision making under uncertainty. Neglecting dependence between multivariate uncertainties can distort model output and prevent a proper understanding of the overall risk. Whenever relevant data for quantifying and modeling dependence between uncertain variables are lacking, expert judgment might be sought to assess a joint distribution. Key challenges for the use of expert judgment for dependence modeling are over- and underspecification. An expert can provide assessments that are infeasible, i.e., not consistent with any probability distribution (overspecification), and on the other hand, without making very restrictive parametric assumptions an expert cannot fully define a probability distribution (underspecification). The sequential refined partitioning method addresses over- and underspecification while allowing for flexibility about which part of a joint distribution is assessed and its level of detail. Potential overspecification is avoided by ensuring low cognitive complexity for experts through eliciting single conditioning sets and by offering feasible assessment ranges. The feasible range of any (sequential) assessment can be derived by solving a linear programming problem. Underspecification is addressed by modeling the density of directly and indirectly assessed distribution parts as minimally informative given their constraints. Hence, our method allows for modeling the whole distribution feasibly and in accordance with experts' information. A nonparametric way of assessing and modeling dependence flexibly in such detail has not been presented in the expert judgment literature for probabilistic dependence models so far. We provide an example of assessing terrorism risk in insurance underwriting.

Approximate Uncertainty Modeling in Risk Analysis with Vine Copulas.

Many applications of risk analysis require us to jointly model multiple uncertain quantities. Bayesian networks and copulas are two common approaches to modeling joint uncertainties with probability distributions. This article focuses on new methodologies for copulas by developing work of Cooke, Bedford, Kurowica, and others on vines as a way of constructing higher dimensional distributions that do not suffer from some of the restrictions of alternatives such as the multivariate Gaussian copula. The article provides a fundamental approximation result, demonstrating that we can approximate any density as closely as we like using vines. It further operationalizes this result by showing how minimum information copulas can be used to provide parametric classes of copulas that have such good levels of approximation. We extend previous approaches using vines by considering nonconstant conditional dependencies, which are particularly relevant in financial risk modeling. We discuss how such models may be quantified, in terms of expert judgment or by fitting data, and illustrate the approach by modeling two financial data sets.

Decision making for group risk reduction: dealing with epistemic uncertainty.

Group risk is usually represented by FN curves showing the frequency of different accident sizes for a given activity. Many governments regulate group risk through FN criterion lines, which define the tolerable location of an FN curve. However, to compare different risk reduction alternatives, one must be able to rank FN curves. The two main problems in doing this are that the FN curve contains multiple frequencies, and that there are usually large epistemic uncertainties about the curve. Since the mid 1970s, a number of authors have used the concept of "disutility" to summarize FN curves in which a family of disutility functions was defined with a single parameter controlling the degree of "risk aversion." Here, we show it to be risk neutral, disaster averse, and insensitive to epistemic uncertainty on accident frequencies. A new approach is outlined that has a number of attractive properties. The formulation allows us to distinguish between risk aversion and disaster aversion, two concepts that have been confused in the literature until now. A two-parameter family of disutilities generalizing the previous approach is defined, where one parameter controls risk aversion and the other disaster aversion. The family is sensitive to epistemic uncertainties. Such disutilities may, for example, be used to compare the impact of system design changes on group risks, or might form the basis for valuing reductions in group risk in a cost-benefit analysis.

A Bayes linear Bayes method for estimation of correlated event rates.

Typically, full Bayesian estimation of correlated event rates can be computationally challenging since estimators are intractable. When estimation of event rates represents one activity within a larger modeling process, there is an incentive to develop more efficient inference than provided by a full Bayesian model. We develop a new subjective inference method for correlated event rates based on a Bayes linear Bayes model under the assumption that events are generated from a homogeneous Poisson process. To reduce the elicitation burden we introduce homogenization factors to the model and, as an alternative to a subjective prior, an empirical method using the method of moments is developed. Inference under the new method is compared against estimates obtained under a full Bayesian model, which takes a multivariate gamma prior, where the predictive and posterior distributions are derived in terms of well-known functions. The mathematical properties of both models are presented. A simulation study shows that the Bayes linear Bayes inference method and the full Bayesian model provide equally reliable estimates. An illustrative example, motivated by a problem of estimating correlated event rates across different users in a simple supply chain, shows how ignoring the correlation leads to biased estimation of event rates.

A role for human reliability analysis (HRA) in preventing drinking water incidents and securing safe drinking water.

The prevalence of water quality incidents and disease outbreaks suggests an imperative to analyse and understand the roles of operators and organisations in the water supply system. One means considered in this paper is through human reliability analysis (HRA). We classify the human errors contributing to 62 drinking water accidents occurring in affluent countries from 1974 to 2001; define the lifecycle of these incidents; and adapt Reason's 'Swiss cheese' model for drinking water safety. We discuss the role of HRA in human error reduction and drinking water safety and propose a future research agenda for human error reduction in the water sector.