Assuntos
Surtos de Doenças , Infecções Estreptocócicas/epidemiologia , Infecções Estreptocócicas/microbiologia , Streptococcus/classificação , Doença Aguda , Portador Sadio/epidemiologia , Portador Sadio/microbiologia , Convalescença , Surtos de Doenças/estatística & dados numéricos , Humanos , Masculino , Militares/estatística & dados numéricos , Faringite/epidemiologia , Faringite/microbiologia , Streptococcus/isolamento & purificação , U.R.S.S./epidemiologiaRESUMO
For typing group A streptococci anti-OF rabbit or guinea-pig sera are usually used in the Al-apoproteinase neutralization test. Still in view of the fact that the technology of the preparation of anti-OF sera with the use of laboratory animals is labor consuming and demands great expense, the use of human donor sera is expedient. A good basis for it is created by a wide spread of streptococcal diseases. At the same time it is impossible to provide a full set of anti-OF sera by the efforts of one laboratory in a single geographical region due to the absence of some types in a given population; for this reason the international bank of sera from donors having antibodies to OF(+) of group A streptococci has been created.
Assuntos
Anticorpos Antibacterianos/isolamento & purificação , Soros Imunes/imunologia , Streptococcus pyogenes/classificação , Adolescente , Adulto , Humanos , Masculino , Padrões de Referência , Sorotipagem/métodos , Sorotipagem/normas , Streptococcus pyogenes/imunologiaRESUMO
The influence of the OF activity of group A streptococci on their specific pathogenic properties has been shown, which is manifested by increased virulence of these streptococci for children of younger age groups and by a two times higher isolation rate of OF+ strains in tonsillitis than in scarlet fever. The possibility of the indirect evaluation of the content of anti-M-antibodies by the results of the anti-OF test has been revealed, which permits using this test instead of the bactericidal test, more complicated, in the study of immunity to infection induced by group A OF+ streptococci. Among the main methods of laboratory support of epidemiological surveillance on streptococcal infection, the introduction of the highly discriminating OF typing and the anti-OF test into practical use is recommended.
Assuntos
Anticorpos Antibacterianos/sangue , Peptídeo Hidrolases/sangue , Infecções Estreptocócicas/imunologia , Streptococcus pyogenes/imunologia , Criança , Pré-Escolar , Humanos , Imunidade/imunologia , Lactente , Peptídeo Hidrolases/imunologia , Federação Russa , Escarlatina/imunologia , Sorotipagem , Streptococcus pyogenes/classificação , Streptococcus pyogenes/isolamento & purificação , Streptococcus pyogenes/patogenicidade , População Urbana , Virulência/imunologiaRESUMO
The possibilities of group A streptococcus typing are opened up, the microorganism being the causative agent of a highly prevalent infectious disease. The first Soviet-made kit of immune anti-OF sera for typing OF-positive group A streptococci have been prepared. A possibility of preparing a human donor kit of anti-OF sera is discussed.