RESUMO
No previous North-African study has evaluated the UHDs understanding of plagiarism (UP). This descriptive study aimed to assess UP among Tunisian UHDs. UHDs were recruited via electronic mails sent to all the Tunisian UHDs through the national health networks and by convenience sampling via a questionnaire provided directly to some UHDs. The French survey, available from the Laval University website, includes 11 questions related to UP, with three-choice answers (yes/no/may be). One point was awarded for each correct answer. A total score lower than six corresponded to a low level of UP. 96 UHDs (69 females) responded to the survey either through emails (39.6%) or by filled in the paper (60.4%). The mean ±SD (95% confidence interval) score of UP was considered low at 5.4 ± 1.9 (5.0 to 5.8); 74% of the participants had a low UP. The UP score was significantly different between the categories of assistants and professors. Data comparison between subjective and objective assessments revealed that significant percentages of UHDs underestimated their low UP. This was more marked in the professors' category. There was no significant correlation between the UP total score and the UHDs' age or professional experience. To conclude, plagiarism is not well-known to North African UHDs. Abbreviations: MD: medical doctor; MSc: master of sciences; PhD: doctor of philosophy; r: Spearman correlation coefficient; SD: standard deviation; UHDs: university hospital doctors; UP: understanding of plagiarism; 95% CI: 95% confidence interval.
Assuntos
Médicos/psicologia , Plágio , Adulto , África do Norte , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Hospitais Universitários , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Inquéritos e QuestionáriosAssuntos
Abandono do Hábito de Fumar , Espirometria , Medicina Geral , Humanos , Pulmão , Projetos PilotoRESUMO
Although meiotic arrest in males is observed in about 25% of azoospermic patients, pure homogeneous arrest in all seminiferous tubules is less frequent, and may be due to mutation of a single gene. However, given the large number of genes involved in meiosis, this gives rises to extensive genetic heterogeneity. Only two genetic abnormalities have been reported on a regular basis: the X-linked exonic TEX11 deletion, and the AZFb microdeletion on the Y chromosome. Other single gene defects were private and found in consanguineous families. Here, we report on a homozygous missense mutation in the gene coding for meiotic double-stranded break formation protein 1 (MEI1; c.C3307T:p.R1103W) observed in two brothers (from a consanguineous Tunisian family) with non-obstructive azoospermia and meiotic arrest. A fertile brother was heterozygous for the mutation. All the queried databases predicted that this mutation is damaging, and it has previously been reported that Mei1 knock-out is associated with meiotic arrest in a murine model. Hence, meiotic arrest in the two brothers was probably caused by an alteration in a gene known to be fundamental for chromosome synapsis.