RESUMO
A case of acute haemolytic anaemia is described in a child. Tx polyagglutination of his red cells was observed, but no direct association with the anaemia could be proved. Polyagglutination was suspected because of irregularities in the AB0 blood grouping. Confirmation of the cryptantigen Tx was made when the patient's red cells were tested with lectins including Arachis hypogaea, Glycine soja, and Vicia cretica. Examination of family members showed Tx polyagglutination on the red cells of 2 siblings. The Tx polyagglutination was a transient phenomenon lasting 4-5.5 months, and could have been caused as the result of some unidentified bacterial or viral infection. Guidelines for transfusion therapy are suggested in patients in whom polyagglutination is recognised.
Assuntos
Agregação Eritrocítica/imunologia , Testes de Hemaglutinação , Isoantígenos/imunologia , Adolescente , Transfusão de Sangue , Agregação Eritrocítica/genética , Agregação Eritrocítica/terapia , Feminino , Humanos , MasculinoRESUMO
An alloantibody is described which detects a high frequency blood group antigen absent from Ko cells but different from all the reported Kell and para-Kell antigens. The family study shows the antigen to be inherited but gives no information about its relationship to the Kell locus. It is suggested that this 'new' para-Kell antigen be called K22.