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Braz J Biol ; 84: e278069, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38865564

RESUMO

Products derived from medicinal plants with antimicrobial activity are considered a promising alternative in the treatment of fungal infections. In this perspective, this study proposed to evaluate the antifungal activity of the dichloromethane fraction of Annona crassiflora Mart. against C. albicans strains. Tests were carried out to determine Minimum Inhibitory Concentration (MIC), Minimum Fungicide Concentration (MFC), microbial growth kinetics, fungal cell wall and membrane mechanisms of action, antifungal biofilm activity, and cytotoxic effects on human erythrocytes. The extract presented MIC and MFC values that ranged from 256 µg/mL to 1,024 µg/mL, with fungicidal activity in the microbial growth kinetics assay. The mechanism of action did not occur through damage to the cell wall or via binding to ergosterol in the membrane, though the fraction presents activity against biofilm and is not cytotoxic in human erythrocytes. The dichloromethane fraction of Annona crassiflora Mart. presented antifungal activity and reduced biofilm growth, without toxicity against human erythrocytes; however, further studies are needed to define its mechanism of action.


Assuntos
Annona , Antifúngicos , Biofilmes , Candida albicans , Cloreto de Metileno , Testes de Sensibilidade Microbiana , Extratos Vegetais , Annona/química , Antifúngicos/farmacologia , Candida albicans/efeitos dos fármacos , Humanos , Extratos Vegetais/farmacologia , Biofilmes/efeitos dos fármacos , Eritrócitos/efeitos dos fármacos
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