Assuntos
Anticorpos Monoclonais/efeitos adversos , Artrite Reumatoide/tratamento farmacológico , Hipersensibilidade a Drogas/etiologia , Eosinofilia/induzido quimicamente , Prurigo/induzido quimicamente , Idoso de 80 Anos ou mais , Anticorpos Monoclonais/uso terapêutico , Eosinofilia/tratamento farmacológico , Etanercepte , Feminino , Humanos , Imunoglobulina G/efeitos adversos , Imunoglobulina G/uso terapêutico , Infliximab , Prurigo/tratamento farmacológico , Receptores do Fator de Necrose Tumoral/uso terapêuticoRESUMO
BACKGROUND/AIM: Extramammary Paget's disease (EMPD) is an intraepidermal adenocarcinoma of apocrine gland-bearing skin. Although surgery remains the mainstay of treatment, loss of tissue function and high recurrence rates have been reported. Recently, topical Imiquimod has been shown as a safe and effective treatment option for extramammary Paget's disease. METHODS: Three patients diagnosed of EMPD of the vulva were treated with a daily application of 5% Imiquimod cream for three weeks, followed by an every other day application for an additional three weeks. RESULTS: Complete clinical and histological remission of the disease was achieved in the three patients. Mild irritation and tenderness were observed as the only side effects. CONCLUSION: Based on our results, we consider that Imiquimod cream is a safe and effective therapeutic option for the treatment of vulvar EMPD. These promising results warrant further studies to determine the real efficacy and safety of Imiquimod 5% cream for the treatment of this uncommon disease.
Assuntos
Aminoquinolinas/administração & dosagem , Antineoplásicos/administração & dosagem , Doença de Paget Extramamária/tratamento farmacológico , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Vulvares/tratamento farmacológico , Administração Tópica , Idoso , Idoso de 80 Anos ou mais , Aminoquinolinas/efeitos adversos , Antineoplásicos/efeitos adversos , Esquema de Medicação , Feminino , Humanos , Imiquimode , Pessoa de Meia-Idade , Indução de RemissãoRESUMO
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