Body procurement in the Dr. Senckenbergische Anatomie in Frankfurt/Main after the Second World War - From unclaimed corpses to body bequests.

The present paper provides a detailed historical and numerical analysis of the processes regarding body procurement in a particular German anatomical institute, namely, the Dr. Senckenbergische Anatomie (DSA) in Frankfurt am Main. It covers the period from 1946 to 1980; i.e. the transitional phase during which unclaimed corpses were replaced by corpses stemming from body donors. The DSA is fortunate to possess the complete set of records spanning that period. Thus, we cannot only document the (failed) organizational and political efforts of the local anatomists and governmental agencies to uphold the unclaimed body system of old, but we can also present rather detailed data regarding the genesis of the system of body donations. In particular, we will provide evidence that this system was more or less self-generating, and that its emergence was not actively propagated by the local anatomists. Instead, it was triggered by both the media and by the donors themselves, with the latter acting as multipliers. In addition we provide, for the first time, data on the efficacy (in terms of "file corpses" vs. real corpses in anatomy) of a body donation system in Germany.

MDA, MDMA, and other "mescaline-like" substances in the US military's search for a truth drug (1940s to 1960s).

This article describes the context in which 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA) and other mescaline-like compounds were explored as hallucinogens for military and intelligence purposes from the 1940s to the 1960s. Germans first tested mescaline as a "truth drug" in a military context. In the 1940s, the United States military started testing hallucinogenic substances as truth drugs for interrogation and behavior manipulation. After tests carried out using mescaline and other drugs in 1950, some derivatives of mescaline were synthesized by the Army for the exploration of possible "speech-inducing" effects. After insufficient animal testing, the substances were given to patients at the New York State Psychiatric Institute (NYSPI). 3,4-Methylenedioxy-N-ethylamphetamine (MDE), a compound almost identical to MDMA, was among the compounds delivered for testing at the NYSPI. During tests with other derivatives (3,4-dimethoxyphenethylamine (DMA), 3,4-methylenedioxyphenethylamine (MDPEA), MDA) in 1952-53, an unwitting patient died in these tests, which was kept secret from the public. Research was interrupted and toxicological animal testing procedures were initiated. The secret animal studies run in 1953/1954 revealed that some of the "mescaline derivatives" tested (e.g. MDA, MDE, DMA, 3,4,5-trimethoxyamphetamine (TMA), MDMA) were considered for further testing in humans. In 1955, the military changed focus to lysergic acid diethylamide (LSD), but some interest in mescaline-like compounds remained for their ability to change mood and habit without interfering with cognition and sensory perception. Based on the known documents, it remains unclear (but probable) whether any of the mescaline derivatives tested were being used operationally.

The History of MDMA as an Underground Drug in the United States, 1960-1979.

MDMA (3,4-methylenedioxy-methylamphetamine, a.k.a. "ecstasy") was first synthesized in 1912 and resynthesized more than once for pharmaceutical reasons before it became a popular recreational drug. Partially based on previously overlooked U.S. government documentation, this article reconstructs the early history of MDMA as a recreational drug in the U.S. from 1960 to 1979. According to the literature, MDMA was introduced as a street drug at the end of the 1960s. The first forensic detection of MDMA "on the street" was reported in 1970 in Chicago. It appears that MDMA was first synthesized by underground chemists in search of "legal alternatives" for the closely related and highly sought-after drug MDA, which was scheduled under the Controlled Substances Act (CSA) in 1970. Until 1974, nearly all MDMA street samples seized came from the U.S. Midwest, the first "hot region" of MDMA use. In Canada, MDMA was first detected in 1974 and scheduled in 1976. From 1975 to 1979, MDMA was found in street samples in more than 10 U.S. states, the West Coast becoming the major "hot region" of MDMA use. Recreational use of MDMA spread across the U.S. in the early 1980s, and in 1985 it was scheduled under the CSA.

Notes on the history of the Dr. Senckenbergische Anatomie in Frankfurt/Main. Part I. Development of student numbers, body procurement, and gross anatomy courses from 1914 to 2013.

Until recently, it was believed that all internal documentation regarding student affairs and body procurement of the Dr. Senckenbergische Anatomie concerning the time before March 1944 - when the building was destroyed during an Allied air raid - was lost. A few years ago, however, we discovered stacks of old documents in the current anatomy building. These documents permitted a reconstruction (1) of the history of body procurement, student numbers and course management from 1914 to 1944, as well as (2) some aspects of the building's history in the time immediately after its destruction that have hitherto not been documented. In this paper (Part I), we will deal with the organizational history of the Dr. Senckenbergische Anatomie from 1914 to 2013, placing special emphasis on the development of the student population and body procurement, as well as on the major changes that occurred in the gross anatomy labs of the last century. More than 30,000 students were trained in the Dr. Senckenbergische Anatomie over the last 100 years, and more than 3000 bodies have been received. The number of incoming bodies has remained quite stable in all these years and is, on average, approximately 32 per year. The number of students entering the gross anatomy lab during that period, however, rose from less than 100 to more than 600. A companion paper (Part II) deals with the years of the Third Reich (1933-1945) in more detail.

Notes on the history of the Dr. Senckenbergische Anatomie in Frankfurt/Main. Part II. The Dr. Senckenbergische Anatomie during the Third Reich and its body supply.

In order to be able to understand how body supply was maintained at the Dr. Senckenbergische Anatomie from 1933 to 1945 - with special emphasis on victims of the National Socialist regime - we have collected information from various and often fragmentary sources. The documents reveal that during this period at least 474 bodies were brought to the anatomical institute. Among them were the bodies of at least 71 prisoners, 51 of whom had been executed, and the bodies of 8 inmates of (labor-) camps. 356 unclaimed bodies were received, some of them may stem from victims of "euthanasia" programs. The sources of 39, as of yet, unnamed bodies could not be verified. The current collections and the catalogs were screened for remains of victims of the National Socialist regime, but none were found. The vast majority of the bodies were used for teaching purposes. Hans Schreiber, one of the directors of the institute, whose biography is provided here, used at least 9 additional executed individuals for his research. Wherever possible, we have identified the victims of the National Socialist regime, executed persons and the inmates of (labor-) camps, whose bodies were used by the anatomists in Frankfurt, by name. Among the victims was Georg Fröba, a communist philanthropist, whose biography is provided.

Rediscovering MDMA (ecstasy): the role of the American chemist Alexander T. Shulgin.

AIMS: Alexander T. Shulgin is widely thought of as the 'father' of +/-3,4-methylenedioxymethamphetamine (MDMA). This paper re-assesses his role in the modern history of this drug. METHODS: We analysed systematically Shulgin's original publications on MDMA, his publications on the history of MDMA and his laboratory notebook. RESULTS: According to Shulgin's book PIHKAL (1991), he synthesized MDMA in 1965, but did not try it. In the 1960s Shulgin also synthesized MDMA-related compounds such as 3,4-methylenedioxyamphetamine (MDA), 3-methoxy-4,5-methylenedioxyamphetamine (MMDA) and 3,4-methylenedioxyethylamphetamine (MDE), but this had no impact on his rediscovery of MDMA. In the mid-1970s Shulgin learned of a 'special effect' caused by MDMA, whereupon he re-synthesized it and tried it himself in September 1976, as confirmed by his laboratory notebook. In 1977 he gave MDMA to Leo Zeff PhD, who used it as an adjunct to psychotherapy and introduced it to other psychotherapists. CONCLUSION: Shulgin was not the first to synthesize MDMA, but he played an important role in its history. It seems plausible that he was so impressed by its effects that he introduced it to psychotherapist Zeff in 1977. This, and the fact that in 1978 he published with David Nichols the first paper on the pharmacological action of MDMA in humans, explains why Shulgin is sometimes (erroneously) called the 'father' of MDMA.