RESUMO
The article contains data on the norming principles for and the biologic action of polymineralic potassium dusts. The analysis and comparison of experimental and clinical data presented potassium ore as a substance characterized by low toxicity and weak fibrogenic action. In animal studies, the general toxic action of potassium aerosols exceeded the fibrogenic effects. MAC was suggested for working zone areas at 5 mg/m3 (3rd class of hazards).
Assuntos
Poeira/efeitos adversos , Minerais/toxicidade , Potássio/toxicidade , Animais , Relação Dose-Resposta a Droga , Dose Letal Mediana , Concentração Máxima Permitida , Camundongos , Minerais/intoxicação , Intoxicação/diagnóstico , Potássio/intoxicação , Ratos , Fatores de TempoRESUMO
Patients with rheumatoid arthritis showed changes of the fatty acid spectrum manifested in a reduction of the polyunsaturated acids (linoleic, linolenic, arachidonic) and an increase of the level of monounsaturated (oleic, palmithooleinic) depended on the course of the disease. Antirheumatic treatment produced a positive effect, especially gold preparations, on normalization of the level of unsaturated fatty acids in rheumatoid arthritis.
Assuntos
Artrite Reumatoide/sangue , Ácidos Graxos Insaturados/sangue , Compostos Organometálicos , Corticosteroides/uso terapêutico , Adulto , Anti-Inflamatórios não Esteroides/uso terapêutico , Antirreumáticos/uso terapêutico , Artrite Reumatoide/tratamento farmacológico , Cromatografia Gasosa , Doença Crônica , Dimercaprol/uso terapêutico , Quimioterapia Combinada , Humanos , Metaloproteínas/uso terapêutico , Pessoa de Meia-Idade , Compostos Organoáuricos , Propanóis , Compostos de SulfidrilaAssuntos
Insuficiência Cardíaca/sangue , Hipertensão/complicações , Calicreínas/sangue , Cininogênios/sangue , Sistema Renina-Angiotensina , Renina/sangue , Fatores Etários , Idoso , Feminino , Insuficiência Cardíaca/etiologia , Humanos , Calicreínas/deficiência , Masculino , Pessoa de Meia-Idade , Renina/deficiênciaRESUMO
To prevent side-effects of chrysotherapy for rheumatoid arthritis the authors recommend a treatment scheme under corticosteroid protection. The proposed method was used in 56 patients with rheumatoid arthritis. Side-effects manifested in allergic eruptions were noted in 3 patients (5.35%) while in the control group of 34 patients who were treated by chrysotherapy according to the routine method complications were observed in 9 patients (26.47%).