[The use of adaptogens for preventing suppurative-septic complications following prostatic adenomectomy]. / Primenenie adaptogenov dlia profilaktiki gnoino-septicheskikh oslozhnenii posle adenoméktomii predstatel'noi zhelezy.

Adaptive antiseptic potential of patients subjected to adenomectomy was quantified by measurement of protein synthesis according to the rate of 3H-thymidine inclusion into leukocytic DNA before and 4 hours after intravenous administration of 0.2 mg/kg prednisolone. In healthy controls this rate, when stimulated by prednisolone, rose 2.18 +/- 0.3-fold whereas in patients the rise did not exceed 1.07 +/- 0.07-fold. One-week administrations of adaptogens increased the latter rate 1.27-2.61-fold leading to less frequent infectious complications. A randomized trial of 118 patients involving the comparison of three different variants of adaptogens treatment against the control revealed the most favourable regimen: 0.15 U/kg im insulin, 0.1 mg/kg prednisolone, 0.2 mg/kg dibazol, 250 mg/kg methyluracil daily for 1 week preoperatively.

[The diagnosis of urosepsis]. / Diagnostika urosepsisa.

Two hundred-five case histories of urosepsis have been analyzed for the recent 10 years in order to delineate diagnostic details. Urosepsis resulted from urolithiasis in 88 (42.9%), prostatic adenoma in 51 (24.9%), urologic cancer in 37 (18%) patients; other 29 patients had urologic diseases complicated by urosepsis. Difficulties with identification and size delineation of a septic focus were associated with the presence of bilateral renal involvement, lower urinary tract infections, urinary reflux and posttransplantation immunosuppressive therapy which reversed classic inflammatory symptoms. Extreme clinical variability of urosepsis often resulted in a delayed or premature diagnosis. Diagnostically revealing studies were sonography and computer tomography. Additional use of blood culture for bacteroides and L-bacteria, immune and biochemical tests, including total polyamine concentration, urea/creatinine ratio and leukocyte toxemic index provided an accurate diagnosis of urosepsis. These studies are essential in older patients and those with urinary disease and urologic cancers since urosepsis is diagnostically elusive in this population.

[Use of perfluorocarbon emulsion in kidney transplantation]. / Ispol'zovanie perftoruglerodnoi émul'sii pri transplantatsii pochek.

Intravenous infusion of perfluorocarbon emulsion (PFCE) during autotransplantation of kidneys which had been stored for 24 hours led to a rapid normalization of intraorganic hemodynamics in dogs, and restoration of ionic homeostasis, energy potential, and functional activity of the transplants. It was shown that the protective effect of PFCE is associated with inhibition of free-radical lipid peroxidation, and the establishment of a stable protein-lipid conformation of the membrane structures of the cells of ischemic organs. It was established that the use of PFCE in the stage of stored kidney transplantation may be an effective method for the prevention of reperfusion damage to the transplant.

[Primary hyperparathyroidism in patients with bilateral nephrolithiasis]. / Pervichnyi giperparatireoz u bol'nykh dvustoronnim nefrolitiazom.

Experience in the diagnosis and treatment of the renal form of primary hyperparathyroidism in 57 patients with bilateral nephrolithiasis was summed up. The main diagnostic criterion was the detection of biochemical changes in the blood and urine (hypercalcemia, hypophosphatemia, hypercalciuria) and the use of some tests (Howard's test and parathyroidin test). Parathyroidectomy was performed after establishing diagnosis. A new stage in therapy of such patients was a study of renal function and phosphocalcium metabolism after parathyroidectomy. The improvement of some indices (an increase in glomerular filtration, urea excretion with urine and relative urine density, and a decrease in hypercalciuria and hyperphosphaturia) indicated the effectiveness of surgical intervention for primary hyperparathyroidism in patients with bilateral nephrolithiasis. It was also confirmed by a decrease in lithogenic relapse after parathyroidectomy.