Apendagitis epiploica como causa inusual de dolor abdominal agudo: características clínicas y radiológicas de 7 pacientes / Epiploic appendagitis as unusual cause of acute abdominal pain: clinical and radiologic features of 7 patients

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Síndrome de Pellegrini-Stieda como causa de gonalgia / Pellegrini-Stieda syndrome as a cause of knee pain

La calcificación de las partes blandas, adyacentes al cóndilo femoral medial, después de una historia de traumatismo en la rodilla, se denomina signo radiológico de Pellegrini-Stieda (PS), cuando se asocia a dolor y a disminución del rango de movilidad de la rodilla se conoce como síndrome de PS. Describimos dos casos de síndrome de PS, tratados mediante tratamiento conservador -reposo y fisioterapia-, los hallazgos radiológicos y ecográficos, y algunas teorías propuestas para explicar la patogénesis de la enfermedad de PS (AU)

Calcification in the soft tissue next to the medial femoral condyle after a history of trauma around the knee is a recognized radiographic finding-PS (Pellegrini-Stieda) sign. When this is associated with pain and a restricted range of motion it is known as the PS syndrome. We describe two cases of PS syndrome, treated conservatively with rest and physiotherapy, as well as the radiographic and ultrasound findings, and the many theories proposed in attempts to explain the pathogenesis of PS disease (AU)

[Pellegrini-Stieda syndrome as a cause of knee pain]. / Síndrome de Pellegrini-Stieda como causa de gonalgia.

Calcification in the soft tissue next to the medial femoral condyle after a history of trauma around the knee is a recognized radiographic finding-PS (Pellegrini-Stieda) sign. When this is associated with pain and a restricted range of motion it is known as the PS syndrome. We describe two cases of PS syndrome, treated conservatively with rest and physiotherapy, as well as the radiographic and ultrasound findings, and the many theories proposed in attempts to explain the pathogenesis of PS disease.

Thiopurine S-methyltransferase (TPMT) genetic polymorphisms in Mexican newborns.

BACKGROUND: Thiopurine S-methyltransferase (TPMT) is involved in the toxicity and therapeutic efficacy of thiopurine drugs, and its gene exhibits genetic polymorphisms that differ across diverse populations. Four TPMT polymorphisms (TPMT*2, *3A, *3B and *3C) account for 80-95% of alleles that cause reduced enzyme activity. To date, only a single study in the Mexican population involving 108 individuals has been performed, but the regional and ethnic origin of this population was not described. Accordingly, information about the TPMT polymorphism in the Mexican population is limited. OBJECTIVE: To determine the TPMT allele and genotype frequencies in a sample of newborns from Mexico City. METHODS: Three hundred and sixty DNA samples from unrelated, anonymous individuals were obtained from dried blood spots collected on filter paper as part of the Newborn Screening National Program. Allele-specific polymerase chain reaction for the TPMT*2 allele and PCR restriction fragment length polymorphism for TPMT*3A, TPMT*3B, TPMT*3C alleles were used to determine the respective allelic and genotypic frequencies. RESULTS AND DISCUSSION: Of 720 TPMT alleles analysed, 49 (6.81%) were deficiency alleles. The most common deficiency allele was TPMT*3A (5.69%), followed by TPMT*3C (0.56%), TPMT*3B (0.28%) and TPMT*2 (0.28%). Fourty-five newborns were heterozygous for one mutant allele (12.5%) and two showed a genotype with two deficiency alleles (0.56%). Despite its unique ethnic composition, our Mexican population exhibited variant allele frequencies that were similar to some Caucasian populations. CONCLUSION: Our data suggest that approximately 1 in 180 persons born in Mexico City might have low or undetectable TPMT enzyme activity, a frequency that, overall, is somewhat higher than that reported for Caucasian populations generally (1 in 300).

[Uterine contraction induced by carbachol is inhibited by melatonin]. / La contracción uterina inducida por carbacol es inhibida por melatonina.

It has been suggested that the pineal gland has a specific role in the regulation of reproductive functions. Melatonin, secreted by pineal gland, is involved in the control of mammalian reproduction. Previous investigations have show that melatonin reduced the smooth muscle contraction. The purpose of the present study was to investigate the effect of melatonin on the uterine contraction provoked by carbachol. This effect was studied in isolated uterus were taken from Wistar rats pretreated with diethylstilboestrol. Here, we describe the effects of various concentrations of melatonin was found to inhibit the carbachol-induced uterine contraction. Our results show that CE50 of carbachol increment in present to 10(-9) and 10(-6) M/ml of melatonin. The degree of the inhibitory effect of melatonin to concentration of 10(-9) M/ml is most evident that 10(-6) M/ml. Thus, it is concluded that melatonin has an pharmacological inhibition effect on the contraction uterine provoked by carbachol, act as physiological antagonist.