Development and validation of the sitting balance assessment for spinal cord injury (SitBASCI).

STUDY DESIGN: Multicentric psychometric study. OBJECTIVES: The aim of this study is to introduce the development of the Sitting Balance Assessment for Spinal Cord Injury (SitBASCI) and assess its inter-rater reliability and internal consistency. SETTING: The study was developed among the three Spinal Units of San Bortolo Hospital in Vicenza, Niguarda Hospital in Milan and AOU Careggi in Florence. METHODS: SitBASCI is a 13-item scale developed to evaluate trunk control in individuals with SCI. Subjects were filmed while performing the 13 items of the scale. The videotapes were submitted to 25 examiners who evaluated patients' performances with the scale. The power of the study was estimated. The interclass correlational coefficient (ICC) was used to assess the inter-rater reliability of the examiner's evaluations regarding each item and the total. Cronbach's alpha was used to assess internal consistency of the scale and internal consistency of the scale on the eliminated item. RESULTS: The study showed to have a significant power. The inter-rater reliability for the total score was ptot = 0.997 (item's values were p = 0.876-0.998). The internal consistency of the scale was alpha = 0.925, while the internal consistency of the scale on the eliminated item was alpha = 0.912-0.930. CONCLUSION: SitBASCI had a high inter-rater reliability and internal consistency. Items had also good inter-rater reliability and item-total correlation. Therefore, SitBASCI could be proposed as a good and reliable instrument for Italian clinicians to evaluate sitting balance and trunk control in patient with SCI despite of aetiology and level of injury.

18F-fluorodeoxyglucose positron-emitted tomography for predicting neurological outcome in hypoxic-ischemic encephalopathy.

Background: 18F-fluorodeoxyglucose positron-emitted tomography (FDG-PET) is a promising yet unexplored functional neuroimaging tool in the study and prognosis of hypoxic-ischemic encephalopathy (HIE) after cardiac arrest or respiratory failure. The present study aimed to correlate clinical data and FDG-PET scans for both analysis and prognostic use. Methods: 24 patients from an intensive rehabilitation ward were retrospectively evaluated. Data collected included age, gender, cause of anoxic event, length of stay in acute and rehabilitation units, discharge destination, and evaluation at admission and discharge using three clinical scales to assess cognitive function, independence and disability. Subjects were identified as good and bad performers on the basis of quantitative analysis of FDG-PET scans with the Cortex ID software. The relation between glucose uptake reduction and neurological outcome was evaluated. Results: good and bad performers presented no statistically significant difference regarding demographical data and in-hospital length of stay. The two categories significantly differed for impairment and disability levels both at admission and at discharge from the inpatient rehabilitation unit. Conclusions: FDG-PET considerably facilitates the early identification of patients with HIE who will have poor neurological outcome and could inform planning for their rehabilitation and care.

Past Life Experiences and Neurological Recovery: The Role of Cognitive Reserve in the Rehabilitation of Severe Post-Anoxic Encephalopathy and Traumatic Brain Injury.

OBJECTIVE: Patients with an equivalent clinical background may show unexpected interindividual differences in their outcome. The cognitive reserve (CR) model has been proposed to account for such discrepancies, but its role after acquired severe injuries is still being debated. We hypothesize that inappropriate investigative methods might have been used when dealing with severe patients, which have very likely reduced the possibility of observing meaningful influences in recovery from severe traumas. METHODS: To overcome this issue, the potential neuroprotective role of CR was investigated, considering a wider spectrum of clinical symptoms ranging from low-level brain stem functions necessary for life to more complex motor and cognitive skills. In the present study, data from 50 severe patients, 20 suffering from post-anoxic encephalopathy (PAE) and 30 with traumatic brain injury (TBI), were collected and retrospectively analyzed. RESULTS: We found that CR, diagnosis, time of hospitalization, and their interaction had an effect on the clinical indexes. When the predictive power of CR was investigated by means of two machine learning classifier algorithms, CR, together with age, emerged as the strongest factor in discriminating between patients who reached or did not reach successful recovery. CONCLUSIONS: Overall, the present study highlights a possible role of CR in shaping the recovery of severe patients suffering from either PAE or TBI. The practical implications underlying the need to routinely considered CR in the clinical practice are discussed.

Effects of a sensory-motor orthotic on postural instability rehabilitation in Parkinson's disease: a pilot study.

BACKGROUND: Proprioceptive deficits have been largely documented in PD patients, thus external sensory signals (peripheral sensory feedback) are often used to compensate the abnormalities of proprioceptive integration. This pilot study aims to evaluate the feasibility and the effectiveness of a rehabilitation-training program, combined with the use of a sensory-motor orthotic in improving balance in a small sample of PD patients. METHODS: Twenty PD patients were randomly allocated into two groups: (i) the Experimental group, where participants were asked to wear a sensory-motor orthotic during the balance training program and (ii) the Control group, where subjects performed an identical training program without wearing any kind of orthotics. In all, the training program lasted 10 sessions (5 days a week for 2 weeks) and the clinical and instrumental assessments were performed at baseline, immediately after the end of the training and 4 weeks after the rehabilitative program was stopped. RESULTS: All clinical outcome measures tested improved significantly at post and follow-up evaluations in both groups. Interestingly, at the end of the training, only the experimental group obtained a significant improvement in the functional reaching test (sway area - eyes closed) measured by means of stabilometric platform and this result was maintained in the follow-up evaluation. CONCLUSIONS: Our preliminary results suggested that the use of a sensory-motor orthotic, in combination with a tailored balance training, is feasible and it seems to positively impact on balance performance in Parkinson's disease. TRIAL REGISTRATION: EudraCT N. 003020-36 - 2013.

18FDG-PET/CT in traumatic brain injury patients: the relative hypermetabolism of vermis cerebelli as a medium and long term predictor of outcome.

PURPOSE: Both, the constant presence of apparent hypermetabolism of the vermis cerebelli compared to the cerebellar hemispheres in traumatic brain injury, and the presence of a good relationship between the intensity of this sign and the severity of the clinical conditions have been addressed in previous studies. Aim of the present paper is to evaluate the possible correlation between the intensity of the finding and the medium and long term outcome in a group of patients. MATERIALS AND METHODS: A group of 105 patients consecutively admitted to the Brain Injury Rehabilitation Center of our Hospital between 2005 and 2012 was studied with a 18FDG-PET/CT study of the brain after head trauma; the metabolic activity of the cerebellar vermis was semiquantitatively assessed (vermis/cerebellum ratio, V/C). After that, all patients received systematic monitoring of their performance status via the timely administration of commonly used tests (DRS, LCF and GOS) during one whole year after the head trauma. The V/C parameter was compared with the evolution of performance abilities, as shown by the rating scales. RESULTS: Statistical analysis showed a significant direct association between the V/C ratio and the DRS score at each time point (3 months: P<0.001; 6 months: P<0.001; 12 months: P<0.001) and significant inverse association with the LCF score (3 months: P<0.001; 6 months: P<0.001; 12 months: P<0.001) and the GOS score (3 months: P<0.001; 6 months: P<0.001; 12 months: P<0.001) at each time point. Moreover, patients with a V/C ratio ≥ 1 have a significantly greater probability to achieve a good functional outcome as defined by a DRS score ≥ 3 points, a LCF score ≥ 7 points and and a GOS score =5 points. CONCLUSIONS: In our group of patients, the V/C parameter has demonstrated to be a predictor of outcome. If validated by more extensive experiences, this approach could offer the possibility of performing a reliable prognostic evaluation in a notoriously "difficult" class of patients with an acceptable technique and economical effort.

Relative hypermetabolism of vermis cerebelli in traumatic brain injured patients studied with 18FDG PET: a descriptor of brain damage and a possible predictor of outcome.

PURPOSE: The almost constant presence of apparent metabolic hypermetabolism of cerebellar vermis seen on 18FDG PET in a population of injured brains has been reported in a previous paper. Aim of this paper is to determine a) whether there is a correlation between the entity of this sign, semi quantitatively determined, and the severity of the trauma at its onset, and b) whether the entity of the relative enhancement correlates with the medium and long term clinical outcome. METHODS: A group of 45 consecutive patients admitted to the Acquired Brain Injury Unit of our Hospital for recent, major head trauma, underwent a basal 18FDG PET/CT scan of the brain; the presence of relative hypermetabolism of the vermis cerebelli was visually assessed and semi quantitatively determined (vermis/cerebellum ratio: V/C); the median V/C value was used as a divide between low V/C ratios (group A) and high V/C ratios (group B). During one year after trauma, every patient from both groups received an extensive testing to evaluate cognitive and behavioral performances and evolution: Disability Rating Scale (DRS) and Levels of Cognitive Function (LCF) were administered monthly from month 1 to month 6, and at 12 months from the trauma; Glasgow Outcome Scale (GOS) was administered at 3, 6 and 12 months from the head trauma. Numerical scores from each of these performance-testing protocols were cross-matched with values derived from the V/C 18FDG PET/CT determinations. A relative risk estimate via Chi-square testing was performed on the results of both groups for LCF and DRS scales at 1, 6 and 12 months from trauma. RESULTS: At one month after trauma, overall LCF (LCF1) values ranged from 2 to 8, avg. 3.77, SD ± 2.10; the average value in group A was 5.21, SD ± 2.09, in B group 2.47, SD ± 0.98 (F=17.5, P = 0). At this time, overall average DRS (DRS1) was 6.7, SD ± 2.05, ranging from 2 to 9; the average value was 5.52, SD ± 0.47 in group A, and 7.72, SD ± 0.30 in group B (F = 6.3, P = 0.01). Relative risk estimates for patients with higher V/C ratios for poor performance in DRS scale were: 2.46 at 1 month (confidence boundaries 1.66 - 3.64), 3.75 (c.b. 1.64 - 8.64) at 6 months, 5.17 (c.b. 1.76 - 15.16) at one year. Relative risk estimates for LCF scale were: 3.20 (c.b. 1.74 - 5.90) at 1 month, 6.909 (c.b. 1.03 - 46.15) at 6 months, 4.22 (c.b. 0.65 - 27.10) at 12 months. CONCLUSIONS: A) there is a strong correlation between the semi quantitatively determined values of vermian relative hypermetabolism and the severity of trauma as determined by standard cognitive and performance testings; the V/C ratio may therefore be considered a reliable, although non-specific, index of brain suffering. B) there is a good statistical correlation between the semi quantitative vermian/cerebellar ratio determined shortly after the trauma, and the clinical outcome of the patients, evaluated by standard clinical performance tests and relative risk estimates.

Reduced startle reflex and aversive noise perception in patients with orbitofrontal cortex lesions.

In the present study, the primary emotional response represented by the acoustic startle reflex was investigated in a group of six male patients, selected with lesions of the orbitofrontal cortex, and twenty matched healthy controls. Accurate neuropsychological assessment and lesion mapping showed relatively spared cognitive functioning in the patient group, most of the lesions being confined to the bilateral polar orbitofrontal cortex. Patients had significant inhibition of startle amplitude, together with a reduced self-evaluated perception of the unpleasantness of the acoustic probe stimulus. Results add to current literature on the circuit of the human startle reflex, by suggesting cortical-limbic down-regulation of the orbitofrontal cortex on the main startle pathway, probably at the level of the activating reticular system. The orbitofrontal cortex, together with the amygdala, is confirmed to represent the main center organizing both primary and secondary learned aspects of emotions.

Cerebellar vermis relative hypermetabolism: an almost constant PET finding in an injured brain.

Cortical alterations of brain metabolism, as seen in PET, obviously depend on the nature of the damage (either mechanical, toxic, anoxic, or other). However, some subcortical abnormalities seem to occur rather frequently regardless of the extension, position and cause of the damage. In particular, relative cerebellar vermis activation seems to be frequently encountered. The aim of this work was to determine the incidence of this pattern in a heterogeneous population of brain trauma, and to compare it on a quantitative basis with a group of age-sex matched controls. The case records of this study consist of 58 consecutive patients, 44 males, 14 females, age 14-69 (median 34) 44 traumatic, 8 anoxic, 4 vascular and 2 toxic injuries. In the trauma group, the visualization of the cerebellar vermis was readily appreciable as a consistent majority of cases. In particular, the mean vermis/cerebellum ratio (calculated by appropriate ROI positioning) was 1.26 +/- 0.17 SD (range 0.92-1.82); in the control group the same parameters showed much less dispersion: average 0.92 +/- 0.06, range 0.80-1.10 (P < 0.005). If, on the basis of the normal group data, a cut-off value of 1 is accepted for the v/c ratio, it is noted that 54/57 trauma patients (95%) showed a ratio above this value. In conclusion, a hypermetabolic cerebellar vermis is a common finding in a damaged brain, regardless of the nature of the trauma (probably due to the relative preservation compared with other structures of alternative metabolic pathways), and seems to be the hallmark of the injured brain.