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1.
Laryngorhinootologie ; 78(8): 417-20, 1999 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-10488460

RESUMO

BACKGROUND: High-resolution CT images are often unable to visualize the extent of possible cochlear obliteration after meningitis or after temporal bone fracture. The exact estimation of this extent, however, is crucial for cochlear implant surgery planning. Thus MR imaging of intralabyrinthine pathology is becoming an increasingly significant imaging modality. METHODS: The clinical relevance of the CISS (constructive interference in steady state) MR sequence is explained using 5 selected cases of different inner ear pathology. RESULTS: Two of the examined patients had unsuspicious inner ear signals, whereas in 3 cases MRI rendered relevant information about partial or total cochlear obliteration. CONCLUSIONS: These clinical examples illustrate how the ideal fluid and tissue contrast of CISS-MRI make this new technique suitable as a primary tool for evaluating inner ear obliteration before cochlear implant surgery.


Assuntos
Doenças Cocleares/diagnóstico , Aumento da Imagem , Processamento de Imagem Assistida por Computador , Doenças do Labirinto/diagnóstico , Imageamento por Ressonância Magnética , Adulto , Criança , Doenças Cocleares/etiologia , Doenças Cocleares/cirurgia , Diagnóstico Diferencial , Feminino , Perda Auditiva Súbita/etiologia , Humanos , Lactente , Doenças do Labirinto/etiologia , Doenças do Labirinto/cirurgia , Masculino , Pessoa de Meia-Idade , Prognóstico , Sensibilidade e Especificidade
2.
Laryngorhinootologie ; 78(6): 304-6, 1999 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-10439347

RESUMO

BACKGROUND: Cochlea Implantation is an accepted treatment for children and adults with profound sensorineural deafness. In rare cases postoperative complications may occur so that removal of the implant is unavoidable. CASE REPORT: In a particular case we present and discuss the case of a 69-year-old patient. CONCLUSION: After removal of a cochlear implant, the electronic array is frequently left in the cochlea as a temporary replacement. This is a common practice, but whether it is advisable should be verified according to the specific intraoperative situation.


Assuntos
Implantes Cocleares/efeitos adversos , Reação a Corpo Estranho/patologia , Reação a Corpo Estranho/cirurgia , Tecido de Granulação/cirurgia , Labirintite/patologia , Labirintite/cirurgia , Idoso , Doença Crônica , Reação a Corpo Estranho/diagnóstico , Tecido de Granulação/patologia , Humanos , Labirintite/diagnóstico , Masculino , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/cirurgia , Tomografia Computadorizada de Emissão
3.
Adv Exp Med Biol ; 419: 271-4, 1997.
Artigo em Inglês | MEDLINE | ID: mdl-9193665

RESUMO

We have screened different mouse strains-including strains with enhanced susceptibility for autoimmune diseases-for deviations of Rt6 gene expression by RT-PCR. Most strains expressed varying amounts of Rt6-1 and Rt6-2. NZW mice, however, do not show any detectable Rt6-2 gene transcripts. BxSB mice show a near complete absence of Rt6-1 gene transcripts. Southern blot and sequence analyses revealed that NZW mice have suffered a deletion of the Rt6.2 gene while the Rt6-1 gene of BxSB mice has been inactivated by a premature stop codon. Thus, these mouse strains represent natural Rt6-2 and Rt6-1 single-gene 'knock-out's, respectively. Since the NZW mouse does not show any gross immunological abnormalities, loss of the Rt6-2 gene by itself is not associated with any obvious immunological phenotype. However, crosses between NZW and certain other mouse strains, e.g. (NZW x NWB)F1 and (NZW x SB)F1 animals, develop a systemic autoimmune disease reminiscent of human lupus erythematosus. Moreover, the BxSB mouse strain is considered to be an independent model for the same disease. It will be of interest to determine whether these spontaneous Rt6 gene defects constitute part of the polygenetic contribution to autoimmune disease in these animals.


Assuntos
ADP Ribose Transferases , Antígenos de Histocompatibilidade/genética , Glicoproteínas de Membrana , Camundongos Knockout/genética , Poli(ADP-Ribose) Polimerases/genética , Animais , Antígenos de Diferenciação de Linfócitos T , Southern Blotting , Proteínas Ligadas por GPI , Camundongos
4.
Mol Immunol ; 33(9): 807-17, 1996 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-8811076

RESUMO

RT6 is an enzymatically active GPI-anchored membrane protein that was originally discovered in the rat as a peripheral T cell alloantigen. It has attracted interest as an activation antigen and because defective RT6-expression coincides with increased susceptibility for autoimmune type I diabetes in the BB rat. Southern blot analyses indicate that the rat carries a single copy RT6 gene whereas the mouse carries a duplication of the homologous locus. We had previously cloned and sequenced a RT6-homologous cDNA from BALB/c mouse spleen. We now report the cloning and characterization of a second RT6-homologue from BALB/c and 129/Sv mice. The two mouse Rt6 genes (designated Rt6-1 and Rt6-2) encode similar open reading frames that are disrupted by conserved introns. The nucleotide sequences of the Rt6-1 and Rt6-2 coding regions show 87% sequence identity, the deduced amino acid sequences 79% identity. The amino acid sequences reveal significant similarity to recently cloned ADP-ribosylating ectoenzymes from rabbit and human skeletal muscle as well as chicken bone marrow cells. RT-PCR analyses reveal that the two Rt6 genes are differentially expressed in distinct inbred mouse strains and that their transcripts are properly processed. Western blot analyses demonstrate that the respective gene products are released from cells by treatment with PI-PLC. The results further show that both mouse Rt6 genes are translated into GPI-anchored cell surface molecules and that Rt6 gene expression is restricted to peripheral lymphoid tissues.


Assuntos
Antígenos de Diferenciação de Linfócitos T/química , Antígenos de Diferenciação de Linfócitos T/genética , Antígenos de Histocompatibilidade/química , Antígenos de Histocompatibilidade/genética , Poli(ADP-Ribose) Polimerases/química , Poli(ADP-Ribose) Polimerases/genética , Sequência de Aminoácidos , Animais , Antígenos de Diferenciação de Linfócitos T/isolamento & purificação , Sequência de Bases , Southern Blotting , Clonagem Molecular , Reações Cruzadas , Antígenos de Histocompatibilidade/isolamento & purificação , Camundongos , Camundongos Endogâmicos BALB C , Dados de Sequência Molecular , Família Multigênica/imunologia , Fosfatidilinositol Diacilglicerol-Liase , Fosfoinositídeo Fosfolipase C , Diester Fosfórico Hidrolases/farmacologia , Poli(ADP-Ribose) Polimerases/isolamento & purificação , Reação em Cadeia da Polimerase , Homologia de Sequência de Aminoácidos , Baço/imunologia , Transcrição Gênica/imunologia
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