1.
Bioorg Med Chem Lett
; 12(23): 3359-62, 2002 Dec 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12419361
RESUMO
Using a pyrrolidine-5,5-trans-lactam template, we have designed small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease. Compound 11a, with an alpha-ethyl P1 substituent and a Boc-valine substituent at the pyrrolidine nitrogen, has an IC(50)=30 microM.