Flow-induced ATP release in patient-specific arterial geometries--a comparative study of computational models.

The importance of the endothelium in the local regulation of blood flow is reflected by its influence on vascular tone by means of vasodilatory responses to many physiological stimuli. Regulatory pathways are affected by mass transport and wall shear stress (WSS), via mechanotransduction mechanisms. In the present work, we review the most relevant computational models that have been proposed to date, and introduce a general framework for modelling the responses of the endothelium to alteration in the flow, with a view to understanding the biomechanical processes involved in the pathways to endothelial dysfunction. Simulations are performed on two different patient-specific stenosed carotid artery geometries to investigate the influence of WSS and mass transport phenomena upon the agonist coupling response at the endothelium. In particular, results presented for two different models of WSS-dependent adenosine-5'-triphosphate (ATP) release reveal that existing paradigms may not account for the conditions encountered in vivo and may therefore not be adequate to model the kinetics of ATP at the endothelium.

An improved baseline model for a human arterial network to study the impact of aneurysms on pressure-flow waveforms.

In this study, an improved and robust one-dimensional human arterial network model is presented. The one-dimensional blood flow equations are solved using the Taylor-locally conservative Galerkin finite element method. The model improvements are carried out by adopting parts of the physical models from different authors to establish an accurate baseline model. The predicted pressure-flow waveforms at various monitoring positions are compared against in vivo measurements from published works. The results obtained show that wave shapes predicted are similar to that of the experimental data and exhibit a good overall agreement with measured waveforms. Finally, computational studies on the influence of an abdominal aortic aneurysm are presented. The presence of aneurysms results in a significant change in the waveforms throughout the network.