RESUMO
In the present work we for the first time on the clinic-genetic material revealed genetic predictors of development of acute disturbance of brain circulation (ADBC) in families of patients with atrial fibrillation (AF) namely polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene. Genotype CC was significantly more often found among patients with AF and ADBC compared with controls (58.1 and 35.2%, respectively, p=0.02) as well as in relatives of probands compared with the control group (59.3 and 35.2%, respectively, p=0.008). With this in relatives with revealed paroxysmal AF and ADBC we also noted presence of CC genotype. Taking into consideration the relationship obtained between polymorphysms of MTHFR gene and AF it was possible to assume that polymorphic marker CC appeared to be a predictor of ADBC in these families.
Assuntos
Fibrilação Atrial , Metilenotetra-Hidrofolato Redutase (NADPH2)/genética , Acidente Vascular Cerebral , Adulto , Idoso , Fibrilação Atrial/complicações , Fibrilação Atrial/genética , Circulação Cerebrovascular/genética , Feminino , Marcadores Genéticos , Predisposição Genética para Doença , Humanos , Masculino , Pessoa de Meia-Idade , Linhagem , Polimorfismo de Nucleotídeo Único , Acidente Vascular Cerebral/etiologia , Acidente Vascular Cerebral/genéticaRESUMO
The study was undertaken to compare transesophageal left atrial pacing (TLAP) and bicycle ergometry (BE) in the detection of residual myocardial ischemia (RMI) in 187 patients with myocardial infarction in the early periods of the disease (on days 20 to 26). The intensity of TLAP and BE was increased up to the threshold and submaximal levels according to the conventional criteria. Among the patients, RMI was detected in 71% with TLAP and in 55% with BE (p less than greater than 0.01). Thus, this suggests that TLAP has advantages over BE in the detection of RMI in patients with myocardial infarction in the early periods of the disease.
