Management of Hypodontia Patient Using a Transitional Implant: A Case Report.

Background: Children with missing anterior teeth have physiological and psychological problems. Out of the many treatment options available, dental implants have advantages in replacing teeth. But, conventional implants in growing individuals are contraindicated due to their osseointegration property. Newer literature suggests transitional implants in growing individuals, which may allow easy removal of requirements in the future. Case description: A 12-year-old female patient visited the department with esthetic concerns. The orthodontic treatment was carried out to correct the malocclusion. An MS transitional implant was used to rehabilitate the missing maxillary left lateral incisor. After 24 months of follow-up, the transitional implant provided optimal esthetic and patient compliance. Conclusion: Transitional implant is a possible mode of rehabilitation in children and adolescents with missing teeth. Systematic planning of treatment can lead to desired esthetic and functional results. How to cite this article: Rathi NV, Baliga S, Thosar NR, et al. Management of Hypodontia Patient Using a Transitional Implant: A Case Report. Int J Clin Pediatr Dent 2023;16(1):186-189.

Estimation of malondialdehyde levels in serum and saliva of children affected with sickle cell anemia.

BACKGROUND: Sickle cell anemia (SCA) is an inherited disorder of hemoglobin synthesis characterized by deformed erythrocytes. Hemoglobin S present in sickle-shaped erythrocytes exhibits an enhanced rate of auto-oxidation compared with normal hemoglobin A. It produces more of reactive oxygen species (ROS) which promotes oxidatively stressed environment. ROS degrade the membranes of sickle cell erythrocytes composed of polyunsaturated lipids and form malondialdehyde (MDA) as a by-product. AIM: The aim of the study is to evaluate and compare the MDA levels of serum and saliva in SCA patients. DESIGN: A total of 150 children aged 4-12 years were divided into two groups: Group A (n = 75) consisting of children suffering from SCA and Group B (n = 75) consisting of healthy children. Blood and saliva samples were collected aseptically from both the groups, and they were subjected to thiobarbituric acid assay. Absorbance was evaluated spectrophotometrically at 531 nm, and the values of concentration of MDA were derived. RESULTS: The mean MDA levels in serum and saliva were 8.9825 ± 1.04 and 0.5152 ± 0.28, respectively, in Group A and they were found to be higher than mean MDA levels of serum (5.87 ± 0.92) and saliva (0.2929 ± 0.06) of Group B and the difference of their mean was found to be statistically significant. CONCLUSION: A significant correlation of the MDA was found in saliva and serum of the patients with SCA. This finding suggests that saliva can be effectively used as a noninvasive alternative for assessing the oxidative stress in patients with SCA.

Determination of toral antioxidant capacity of saliva in sickle cell anemic patients - A cross-sectional study.

BACKGROUND: Sickle cell anemia is a congenital hemoglobinopathy characterized by deformed red blood cells. Oxidative stress plays an important role in the pathophysiology of sickle cell anaemia as it destroys free radicals, and thereby depleting the protective mechanisms such as antioxidants in serum. These antioxidants are essential to protect against harmful oxidation-reduction reactions preventing oxidative damage to the cells. AIM: To evaluate and compare the Total Antioxidant Capacity (TAC) of serum and saliva in sickle cell anemia patients. MATERIALS AND METHODS: A total of 150 children aged 4-12 yrs were selected and divided into two equal groups: Children suffering from sickle cell anemia and healthy controls. Blood and saliva samples were collected aseptically from both groups and were subjected to phosphomolybdenum method. Absorbance was read spectrophotometrically at 695 nm. The concentration of total antioxidants was obtained by plotting absorbance of the test against the standard graph. RESULTS: TAC levels in serum (0.29±0.19) and saliva (0.29±0.14) of sickle cell anaemic patients was reduced when compared with serum (0.32+ 0.18) and saliva (0.33+ 0.16) of the healthy children. The correlation between levels of TAC in saliva and serum was found to be statistically significant in sickle cell anaemic patients. CONCLUSION: A significant correlation of the TAC was found in saliva and serum of the patients with SCA suggests that saliva could be used as a non invasive alternative for assessing the antioxidant status in patients with SCA.