Detection and diagnosis of melanoma skin cancers in dermoscopic images using pipelined internal module architecture (PIMA) method.

Detection and diagnosis of melanoma skin cancer is important to save the life of humans. The main objective of this article is to perform both detection and diagnosis of the skin cancers in dermoscopy images. Both skin cancer detection and diagnosis system uses deep learning architectures for the effective performance improvement as the main objective. The detection process involves by identifying the cancer affected skin dermoscopy images and the diagnosis process involves by estimating the severity levels of the segmented cancer regions in skin images. This article proposes parallel CNN architecture for the classification of skin images into either melanoma or healthy. Initially, color map histogram equalization (CMHE) method is proposed in this article to enhance the source skin images and then thick and thin edges are detected from the enhanced skin image using the Fuzzy system. The gray-level co-occurrence matrix (GLCM) and Law's texture features are extracted from the edge detected images and these features are optimized using genetic algorithm (GA) approach. Further, the optimized features are classified by the developed pipelined internal module architecture (PIMA) of deep learning structure. The cancer regions in the classified melanoma skin images are segmented using mathematical morphological process and these segmented cancer regions are diagnosed into either mild or severe using the proposed PIMA structure. The proposed PIMA-based skin cancer classification system is applied and tested on ISIC and HAM 10000 skin image datasets. RESEARCH HIGHLIGHTS: The melanoma skin cancer is detected and classified using dermoscopy images. The skin dermoscopy images are enhanced using color map histogram equalization. GLCM and Law's texture features are extracted from the enhanced skin images. To propose pipelined internal module architecture (PIMA) for the classification of skin images.

An efficient and magnetically recoverable g-C3N4/ZnS/CoFe2O4 nanocomposite for sustainable photodegradation of organic dye under UV-visible light illumination.

Effective improvement of an easily recoverable photocatalyst is equally vital to its photocatalytic performance from a practical application view. The magnetically recoverable process is one of the easiest ways, provided the photocatalyst is magnetically strong enough to respond to an external magnetic field. Herein, we prepared graphitic carbon nitride nanosheet (g-C3N4), and ZnS quantum dots (QDs) supported ferromagnetic CoFe2O4 nanoparticles (NPs) as the gC3N4/ZnS/CoFe2O4 nanohybrid photocatalyst by a wet-impregnation method. The loading of CoFe2O4 NPs in the g-C3N4/ZnS nanohybrid resulted in extended visible light absorption. The ferromagnetic g-C3N4/ZnS/CoFe2O4 nanohybrid exhibited better visible-light-active photocatalytic performance (97.11%) against methylene blue (MB) dye, and it was easily separable from the aqueous solution by an external bar magnet. The g-C3N4/ZnS/CoFe2O4 nanohybrid displayed excellent photostability and reusability after five consecutive cycles. The favourable band alignment and availability of a large number of active sites affected the better charge separation and enhanced photocatalytic response. The role of active species involved in the degradation of MB dye during photocatalyst by g-C3N4/ZnS/CoFe2O4 nanohybrid was also investigated. Overall, this study provides a facile method for design eco-friendly and promising g-C3N4/ZnS/CoFe2O4 nanohybrid photocatalyst as applicable in the eco-friendly dye degradation process.

Visible light driven reduced graphene oxide supported ZnMgAl LTH/ZnO/g-C3N4 nanohybrid photocatalyst with notable two-dimension formation for enhanced photocatalytic activity towards organic dye degradation.

In this study, 2D/2D/2D heterostructured r-GO/LTH/ZnO/g-C3N4 nanohybrid were synthesized through hydrothermal method. The strong electrostatic interaction between the negatively charged g-C3N4 and r-GO nanosheets with positively charged layered triple hydroxide (LTH) nanosheets are effectively influences the successful formation of heterojunction. The LTH nanosheets are well spread on the g-C3N4 nanosheets combined with r-GO. In particular, the as prepared heterojunction shows a better photocatalytic degradation activity compared to pristine samples and the significant enhancement in the photocatalytic performance is mainly accredited to the large interfacial charge transition of photogenerated charge carriers under the visible light irradiation. Although the 2D/2D/2D heterojunction effectively hinders the charge carrier recombination resulting high photocatalytic activity with good stability. In addition, the r-GO supported LTH/ZnO/g-C3N4 heterojunction shows high photo-stability after sequential experimental runs with no obvious change in the dye degradation process. Consequently, the role of active species was investigated over the r-GO/LTH/ZnO/g-C3N4 heterojunction with the help of different scavengers.

Rabies encephalitis in a preschool child following postexposure prophylaxis.

We report a case of rabies encephalitis in a 4½-year-old male child with an exposure to a suspect rabid dog. The child developed rabies 25 days after receiving postexposure prophylaxis. Rabies immunoglobulin (RIG) is currently administered according to body weight. In high-risk exposures over the head and neck, local administration of RIG over and above the body weight depending on the site, size, and severity of exposure may help to prevent rabies death. There is a need for further studies to generate new evidence in this regard.

Construction of magnetically recoverable ZnS-WO3-CoFe2O4 nanohybrid enriched photocatalyst for the degradation of MB dye under visible light irradiation.

Easily recyclable photocatalysts have received considerable attention for their practical application, in order to address the wastewater treatments. Here, we report efficient and magnetically recyclable ZnS-WO3-CoFe2O4 nanohybrid prepared through wet impregnation method. The photophysical and optical properties of as-prepared photocatalysts was investigated by different spectroscopic techniques. The photocatalytic activity of as synthesized samples were assessed by the photodegradation of methylene blue (MB) dye under visible light irradiation. Amongst, ZnS-WO3-CoFe2O4 nanohybrid exhibit higher photodegradation activity than the other bare and hybrid samples. The enhanced light absorption and lower emission intensity provide the improved photocatalytic activity of ZnS-WO3-CoFe2O4 nanohybrid. The ZnS-WO3-CoFe2O4 nanohybrid exhibit excellent photostability after four consecutive cycles. The ferromagnetic behavior of the hybrid sample using easily recover from the dye solution using an external bar magnet.

Outbreak investigation of fever mimicking dengue in Havelock Island, an important tourist destination in the Andaman & Nicobar Archipelago, 2014.

An upsurge of fever cases of unknown origin, but resembling dengue and leptospirosis was reported in Havelock, Andaman & Nicobar Islands, an important tourism spot, during May 2014. Investigations were carried out to determine the aetiology, and to describe the epidemiology of the outbreak. The data on fever cases attending Primary Health Centre (PHC), Havelock showed that the average number of cases reporting per week over the last 2 years was 46·1 (95% confidence interval 19·4-72·9). A total of 27 (43·5%) patients out of the 62 suspected cases were diagnosed as having DENV infection based on a positive enzyme immunoassay or reverse transcriptase-polymerase chain reaction. The overall attack rate was 9·4 cases/1000 population and it ranged between 2·8 and 18·8/1000 in different villages. The nucleotide sequencing showed that the virus responsible was DENV-3. DENV-3 was first detected in the Andaman & Nicobar Islands in 2013 among wharf workers in Port Blair and within a year it has spread to Havelock Island which is separated from South Andaman by 36 nautical miles.

Emergence of influenza A (H1N1) PDM09 in the remote Islands of India--a molecular approach.

BACKGROUND: A disease outbreak of A (H1N1) PDM09 was reported in Andaman and Nicobar islands in 2009 with an attack rate of 33.5% among settler population and 26.3% among the aboriginal Nicobarese tribe. During the ongoing outbreak of A (H1N1) PDM09 disease in different parts of the world, a subject working in Dubai city of Saudi Arabia, came to Port Blair, following which the pandemic triggered for the first time in these Islands. MATERIALS AND METHODS: During the period August 2009 to January 2011, 30 confirmed cases of Influenza A (H1N1) PDM09 virus infection was detected. To understand the genetic relationship, the NA gene sequences of the viruses were phylogenetically analysed together along with the virus sequence isolated from other parts of the world. RESULT: Formation of multiple clusters were observed, with the sequences of Andaman Islands, mainland India, Mexico, Saudi Arabia and few other counties clustering together. The sequence analysis data revealed that there was no specific mutation conferring resistance to oseltamivir among the Andaman A (H1N1) PDM09 virus isolates. The result of phylogenetic analysis have also revealed that the A (H1N1) PDM09 virus might have spread in these remote Islands of India via the subject from Saudi Arabia/Dubai. CONCLUSION: A (H1N1) PDM09 Influenza outbreak have highlighted the need to strengthen the region-specific pandemic preparedness plans and surveillance strategies.

Genital self-mutilation in depression: a case report.

Genital self-mutilation is a rare severe form of self-injurious behaviour usually described in psychotic disorders with delusions & hallucinations. It has been ascribed to sexual conflicts, body image distortion, internalized aggression and suicidal intent. This phenomenon has been described in schizophrenia, affective psychosis, alcohol intoxication and personality disorders. In the present case genital self-mutilation in a case of Major-Depressive Disorder in an 82 yrs old male is being reported and psychosocial factors are discussed. This case has some unusual features.