To evaluate the effect of anodized dental implant surface on cumulative implant survival and success. A systematic review and meta-analysis.

Background: There have been certain apprehensions regarding the use of surface-modified dental implants due to peri-implant infection and crestal bone loss over the years. Thus, this review aims to evaluate the long-term effect of anodized implant surface on cumulative implant survival (CSR) and success rates in relation to marginal bone loss (MBL). Materials and Methods: Systematic electronic search was done using two databases, PubMed and Embase to assess the potentially relevant records from January 2008 to October 2019. Publications reporting cumulative survival and success rates with anodized dental implants were identified. Screening for duplicate articles and extraction of data was carried out to formulate evidence tables. Meta-analysis was conducted following PRISMA guidelines. Results: Out of 217 observational clinical studies, 8 studies were selected based on predefined selection criteria. The summary estimate for the included studies for CSR was reported as 0.98 (95% confidence interval [CI]: 0.96; 0.99). The heterogeneity (I2 = 37.3%) among these studies was found to be statistically nonsignificant (P = 0.1314). The mean values of MBL after the implant insertion were 0.84 mm at 0-1 year and 1.05mm by the end of follow-up period. This data were provided by five studies only. The mean difference of the analyzed studies came out to be 0.49 mm with a 95% CI (-0.22; 1.19). The heterogeneity (I 2 = 97%) for these studies was statistically significant with P < 0.01. Conclusion: The anodized dental implants have demonstrated long-term survival and success rates in terms of clinical outcomes.

A comparison of oral health status in diabetic and non-diabetic patients receiving hemodialysis - A systematic review and meta-analysis.

AIM(S): To assess and compare the impact of diabetes on the overall oral health status of hemodialytic patients. MATERIALS AND METHODS: Four databases were searched with a manual search for relevant studies. This review compared periodontal health status, dental status, salivary changes, objective and subjective manifestations between diabetic and non-diabetic patients undergoing hemodialysis. Results were reported according to the PRISMA guidelines. RESULTS AND CONCLUSION: (s): Despite few constraints, this review showed that diabetic patients on hemodialysis therapy are at greater risk of developing periodontal disease, and other oral manifestations. Therefore, it has been observed that concomitant diabetes increases oral health problems in a patient undergoing hemodialysis.

Impact of concurrent diabetes on periodontal health in patients with acromegaly.

Previous studies have suggested excess GH/IGF1 secretion in patients with acromegaly is protective for periodontal health. Diabetes is prevalent comorbidity in patients of acromegaly and is associated with worsening of periodontal disease. The present study evaluates the periodontal health and cytokines status in treatment-naive active acromegaly patients with and without diabetes. Eleven patients, each of acromegaly with and without diabetes and 20 healthy controls were enrolled. Periodontal parameters were assessed. GCF and blood samples for IL-6, TGF-ß1, and PDGF were obtained. Serum GH, IGF1, HbA1c, pituitary hormones and MRI sella were performed in patients with acromegaly. There was no significant difference in periodontal status of patients with acromegaly and healthy controls. However, a significant increase in serum IL-6 (p = 0.019) and TGF-ß1 (p = 0.025) levels in patients with acromegaly was observed and all patients had concurrent hypogonadism. Nevertheless, the patients with acromegaly having diabetes had modestly higher CAL and PD and serum IL-6 levels (p = 0.051), but it could not exert adverse effects on periodontal health in presence of GH/IGF1 excess. GH/IGF1 excess did not exert a protective effect on periodontal status in acromegaly, possibly due to concurrent hypogonadism and opposing cytokines; however, it could mask the ill-effects of diabetes on periodontal health.

Periodontal Infectogenomics.

Periodontal diseases are chronic infectious disease in which the pathogenic bacteria initiate the host immune response leading to the destruction of tooth supporting tissue and eventually result in the tooth loss. It has multifactorial etiological factors including local, systemic, environmental and genetic factors. The effect of genetic factors on periodontal disease is already under extensive research and has explained the role of polymorphisms of immune mediators affecting disease response. The role genetic factors in pathogens colonisation is emerged as a new field of research as "infectogenomics". It is a rapidly evolving and high-priority research area now days. It further elaborates the role of genetic factors in disease pathogenesis and help in the treatment, control and early prevention of infection. The aim of this review is to summarise the contemporary evidence available in the field of periodontal infectogenomics to draw some valuable conclusions to further elaborate its role in disease pathogenesis and its application in the clinical practice. This will open up opportunity for more extensive research in this field.

Rare Opportunistic Bread Mold Fungal Infection of Maxillary Sinus in a Diabetic Patient.

Mucormycosis is a rare potentially fatal opportunistic fungal infection that affects human beings. Normally, a healthy is immune to such infections but there are some risk factors which predispose a person to mucormycosis, of which malnutrition and diabetes mellitus are the most common risk factors. India is the most commonly affected country by mucormycosis because of high proportion people with low socioeconomic status and diabetes mellitus. In diabetes mellitus, mucormycosis is more aggressive and fatal due to an impaired host defense mechanism. In spite of being a rare and fatal fungal infection, early diagnosis and prompt multidisciplinary treatment comprising control of underlying predisposing factor, surgical management, and medical management can be helpful in such cases.

Comparative Evaluation of Oral Health Knowledge, Practices and Attitude of Pregnant and Non-Pregnant Women, and Their Awareness Regarding Adverse Pregnancy Outcomes.

BACKGROUND: Adverse pregnancy outcomes are undesirable events occurring during pregnancy and childbirth in mother or child, such as Preterm Low Birth Weight (PLBW) and preeclampsia. There is growing evidence that periodontitis may be a risk factor for preterm birth even after adjusting for known risk factors. AIM: 1. To determine the knowledge and attitude of pregnant females about oral health. 2. To evaluate the oral hygiene practices of pregnant females. 3. To evaluate their awareness regarding effect of oral health on adverse pregnancy outcomes. 4. To assess whether there was any significant difference from their non pregnant counter parts. 5. To evaluate whether their awareness towards dental treatment had increased after conceiving. MATERIALS AND METHODS: 200 pregnant and 200 non-pregnant women filled up a validated questionnaire which comprised of questions on personal data, oral hygiene knowledge, attitude, oral hygiene practices and their awareness regarding the correlation of oral health to adverse pregnancy outcomes. STATISTICAL ANALYSIS: Analyses were conducted using SPSS for Windows (version 15.0; SPSS Inc., Chicago, IL, USA). RESULTS: The results indicate no statistically significant differences in the variables assessed in both the groups, indicating that no further knowledge had been imparted to the women after they conceived. 96% women of both groups (p>0.05) had received no knowledge from the gynaecologist regarding the impact of oral health on pregnancy outcomes. 93.9% of pregnant women, and 89.5% of non pregnant women (p>0.05) did not go for routine dental check-ups. Only 3% of pregnant women were aware of oral health having a correlation with adverse pregnancy outcomes. CONCLUSION: In our study, pregnancy did little to change future attitudes to dental care. To provide better oral health care, more knowledge needs to be made available to the pregnant women and the medical community.

Evaluation of the relative efficacy of copolymerized polylactic-polyglycolic acids alone and in conjunction with polyglactin 910 membrane in the treatment of human periodontal infrabony defects: a clinical and radiological study.

BACKGROUND: Absorbable synthetic biopolymers have been used as bone filler in Periodontology, proving effective stimulants to bone regeneration. AIM: Copolymerized polylactic and polyglycolic acid is used as a bone filler and polyglactin 910 as a guided tissue regeneration (GTR) membrane to achieve regeneration in periodontal infrabony defects. MATERIALS AND METHODS: Forty patients with two- or three-walled infrabony defects were selected and randomly divided into two groups. Group A included patients treated with polylactic-polyglycolic acids 50:50 (Fisiograft ,Ghimsa SPA,Via Fucini, Italy) alone and Group B included patients treated with polylactic-polyglycolic acids (PLA-PGA)50:50 in conjunction with polyglactin acid 910 (Vicryl Mesh Johnson&Johnson , U.S.A ). Evaluation of clinical parameters probing depth and attachment level and radiographs was done preoperatively and 12 and 24 weeks postoperatively. RESULTS: Both the groups showed statistically significant mean reduction in probing depth and gain in clinical attachment level and linear bone fill. CONCLUSIONS: Within the limit of this study, both the treatment modalities are beneficial for the treatment of infrabony defects.

Sturge - Weber syndrome: A case report.

Sturge-Weber angiomatosis is a rare, nonhereditary developmental condition characterized by a hamartomatous vascular proliferation involving the tissues of brain and face. A report of a case with facial port wine stains, gingival overgrowth, and dilated ocular vessels is described.