Bio-medical imaging (X-ray, CT, ultrasound, ECG), genome sequences applications of deep neural network and machine learning in diagnosis, detection, classification, and segmentation of COVID-19: a Meta-analysis & systematic review.

This review investigates how Deep Machine Learning (DML) has dealt with the Covid-19 epidemic and provides recommendations for future Covid-19 research. Despite the fact that vaccines for this epidemic have been developed, DL methods have proven to be a valuable asset in radiologists' arsenals for the automated assessment of Covid-19. This detailed review debates the techniques and applications developed for Covid-19 findings using DL systems. It also provides insights into notable datasets used to train neural networks, data partitioning, and various performance measurement metrics. The PRISMA taxonomy has been formed based on pretrained(45 systems) and hybrid/custom(17 systems) models with radiography modalities. A total of 62 systems with respect to X-ray(32), CT(19), ultrasound(7), ECG(2), and genome sequence(2) based modalities as taxonomy are selected from the studied articles. We originate by valuing the present phase of DL and conclude with significant limitations. The restrictions contain incomprehensibility, simplification measures, learning from incomplete labeled data, and data secrecy. Moreover, DML can be utilized to detect and classify Covid-19 from other COPD illnesses. The proposed literature review has found many DL-based systems to fight against Covid19. We expect this article will assist in speeding up the procedure of DL for Covid-19 researchers, including medical, radiology technicians, and data engineers.

PulDi-COVID: Chronic obstructive pulmonary (lung) diseases with COVID-19 classification using ensemble deep convolutional neural network from chest X-ray images to minimize severity and mortality rates.

Background and Objective: In the current COVID-19 outbreak, efficient testing of COVID-19 individuals has proven vital to limiting and arresting the disease's accelerated spread globally. It has been observed that the severity and mortality ratio of COVID-19 affected patients is at greater risk because of chronic pulmonary diseases. This study looks at radiographic examinations exploiting chest X-ray images (CXI), which have become one of the utmost feasible assessment approaches for pulmonary disorders, including COVID-19. Deep Learning(DL) remains an excellent image classification method and framework; research has been conducted to predict pulmonary diseases with COVID-19 instances by developing DL classifiers with nine class CXI. However, a few claim to have strong prediction results; because of noisy and small data, their recommended DL strategies may suffer from significant deviation and generality failures. Methods: Therefore, a unique CNN model(PulDi-COVID) for detecting nine diseases (atelectasis, bacterial-pneumonia, cardiomegaly, covid19, effusion, infiltration, no-finding, pneumothorax, viral-Pneumonia) using CXI has been proposed using the SSE algorithm. Several transfer-learning models: VGG16, ResNet50, VGG19, DenseNet201, MobileNetV2, NASNetMobile, ResNet152V2, DenseNet169 are trained on CXI of chronic lung diseases and COVID-19 instances. Given that the proposed thirteen SSE ensemble models solved DL's constraints by making predictions with different classifiers rather than a single, we present PulDi-COVID, an ensemble DL model that combines DL with ensemble learning. The PulDi-COVID framework is created by incorporating various snapshots of DL models, which have spearheaded chronic lung diseases with COVID-19 cases identification process with a deep neural network produced CXI by applying a suggested SSE method. That is familiar with the idea of various DL perceptions on different classes. Results: PulDi-COVID findings were compared to thirteen existing studies for nine-class classification using COVID-19. Test results reveal that PulDi-COVID offers impressive outcomes for chronic diseases with COVID-19 identification with a 99.70% accuracy, 98.68% precision, 98.67% recall, 98.67% F1 score, lowest 12 CXIs zero-one loss, 99.24% AUC-ROC score, and lowest 1.33% error rate. Overall test results are superior to the existing Convolutional Neural Network(CNN). To the best of our knowledge, the observed results for nine-class classification are significantly superior to the state-of-the-art approaches employed for COVID-19 detection. Furthermore, the CXI that we used to assess our algorithm is one of the larger datasets for COVID detection with pulmonary diseases. Conclusion: The empirical findings of our suggested approach PulDi-COVID show that it outperforms previously developed methods. The suggested SSE method with PulDi-COVID can effectively fulfill the COVID-19 speedy detection needs with different lung diseases for physicians to minimize patient severity and mortality.

Application of Deep Learning Techniques in Diagnosis of Covid-19 (Coronavirus): A Systematic Review.

Covid-19 is now one of the most incredibly intense and severe illnesses of the twentieth century. Covid-19 has already endangered the lives of millions of people worldwide due to its acute pulmonary effects. Image-based diagnostic techniques like X-ray, CT, and ultrasound are commonly employed to get a quick and reliable clinical condition. Covid-19 identification out of such clinical scans is exceedingly time-consuming, labor-intensive, and susceptible to silly intervention. As a result, radiography imaging approaches using Deep Learning (DL) are consistently employed to achieve great results. Various artificial intelligence-based systems have been developed for the early prediction of coronavirus using radiography pictures. Specific DL methods such as CNN and RNN noticeably extract extremely critical characteristics, primarily in diagnostic imaging. Recent coronavirus studies have used these techniques to utilize radiography image scans significantly. The disease, as well as the present pandemic, was studied using public and private data. A total of 64 pre-trained and custom DL models concerning imaging modality as taxonomies are selected from the studied articles. The constraints relevant to DL-based techniques are the sample selection, network architecture, training with minimal annotated database, and security issues. This includes evaluating causal agents, pathophysiology, immunological reactions, and epidemiological illness. DL-based Covid-19 detection systems are the key focus of this review article. Covid-19 work is intended to be accelerated as a result of this study.

Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization.

The discovery of a series of thiophenephenylsulfonamides as positive allosteric modulators (PAM) of α7 nicotinic acetylcholine receptor (α7 nAChR) is described. Optimization of this series led to identification of compound 28, a novel PAM of α7 nicotinic acetylcholine receptor (α7 nAChR). Compound 28 showed good in vitro potency, with pharmacokinetic profile across species with excellent brain penetration and residence time. Compound 28 robustly reversed the cognitive deficits in episodic/working memory in both time-delay and scopolamine-induced amnesia paradigms in the novel object and social recognition tasks, at very low dose levels. Additionally, compound 28 has shown excellent safety profile in phase 1 clinical trials and is being evaluated for efficacy and safety as monotherapy in patients with mild to moderate Alzheimer's disease.