An epidemiological study on home injuries among children of 0-14 years in South Delhi.

BACKGROUND: Injuries are an important public health problem worldwide, accounting for 5 million deaths, of which unintentional injuries account for 0.8 million deaths in children. Though there are many factors responsible for injury in the home, the environment plays an important role. OBJECTIVES: The objectives were to study the magnitude and pattern of home injuries in children aged 0-14 years and to assess the environmental risk associated with home injuries. METHODS: A community-based, cross-sectional study was conducted in 2015 in a ward of Mehrauli containing 20,800 households, and the total sample of children was selected from 400 households by systematic random sampling, with sampling interval being 52. Information was taken using a predesigned, semi-structured, pretested proforma from both the parents and children. The data collected were analyzed using SPSS version 12. RESULTS:: The prevalence of home injury was found to be 39.7% in the last 1 year, significantly higher in the age group of 1-3 years (54.3%) followed by 5-10 years (45.1%) (P = 0.000). The total number of injuries and the average number of injuries in girls were significantly higher than those of boys. The most common type of home injury was falls (59.5%) followed by injury with sharps and burn injury. The environmental risk was assessed using standard and working definitions and found unsafe electrical points (95.3%), unsafe stairs (100%), unsafe kitchen with access to sharps (29.3%), access to active fire (19.3%), and unsafe furniture and objects (22.8%). CONCLUSION: Though home injury did not occur in 60% of the children during the study period, the risk of injury in the future is high. Educating the parents and the children at schools and environmental modification are important strategies for prevention of home injury.

Monte Carlo and ray tracing algorithms in the cyberknife treatment planning for lung tumours- comparison and validation.

Multiplan treatment planning system, used with Cyberknife system, provides the option of using either the ray tracing algorithm or the Monte Carlo algorithm for the final dose calculation. In order to compare and validate the dose calculations of these algorithms, especially in a heterogeneous medium, a lung phantom study was carried out. Validation has been done with thermoluminiscent dosimetry (TLD) using lithium fluoride rods for the point doses and film dosimetry using EBT2 films for the dose distribution. In the point dose measurements, an agreement of 100.1+2.6 % (1 SD) is observed with the Monte Carlo dose calculation, whereas it is only 91.2+ 3.2% (1 SD) with the ray tracing calculation. On subjecting the dose distributions from irradiated EBT2 films for validation of Monte Carlo calculation MC , over 96% of the pixels pass the gamma criteria of 3mm and 3cGy.On analyzing the dose profiles from EBT2 films and the corresponding profiles from the plan calculated using the Monte Carlo algorithm, it is seen that the maximum distance-to-agreement values are within the 3mm criteria set, whereas the maximum values are as high as 8 mm when compared with plan calculated using ray tracing algorithm. The results of the actual measurements are more consistent with the dose calculation by the Monte Carlo algorithm.

A report on anti-oedemogenic activity of Byttneria herbacea roots--possible involvement of histamine receptor (type I).

ETHNOPHARMACOLOGICAL RELEVANCE: The traditional healers of the Kol tribes of West Bengal, Bihar and Jharkhand (India), widely use the woody rootstock of Byttneria herbacea to reduce the swelling of limbs, due to filariasis. Besides filariasis different part of this plant is used for the treatment of cholera, diarrhoea and asthma. AIM OF THIS STUDY: This study is a preliminary attempt to evaluate the anti-oedemogenic activity of the roots of Byttneria herbacea. MATERIALS AND METHODS: The anti-oedemogenic activity of the hydroalcoholic extract of the roots of Byttneria herbacea (HBH) was evaluated against carrageenan and histamine induced rat paw oedema, acetic acid induced writhing and histamine induced vascular permeability in mice. Further, the effect of HBH on the expression of human histamine receptor type I (H1R) was studied in HeLa cells. RESULTS: HBH exhibited significant dose-dependent inhibition (*p<0.05) against carrageenan and histamine induced rat paw oedema. Similar significant dose-dependent inhibition was observed against acetic acid induced writhing and histamine-induced vascular permeability in mice. Moreover, H1R specific mRNA expression was also significantly (*p<0.05) suppressed by HBH. CONCLUSION: HBH was observed to possess anti-oedemogenic activity which is probably mediated through suppression of H1R.