Familial bilateral pheochromocytoma: a case report / 中华泌尿外科杂志

Familial pheochromocytoma belongs to autosomal dominant inheritance, and has complex and variable clinical manifestations. A child with bilateral PHEO was admitted to our hospital. His grandmother, father and brother were all diagnosed with PHEO, and his aunt was diagnosed with paraganglioma. The child underwent laparoscopic left partial adrenalectomy and open surgery for the contralateral tumor, and was in good postoperative condition. The blood pressure returned to normal and there was no local recurrence and metastasis during the follow-up of 8 months after the second operation.

Advantages and disadvantages of ureteroscope in the diagnosis and treatment of upper tract urothelial carcinoma / 现代泌尿外科杂志

Ureteroscopy plays an important role in the diagnosis and treatment of upper tract urothelial carcinoma (UTUC). Conventional ureteroscopy (URS) can not only identify the location, appearance and size of a tumor, but also assess tumor grade by biopsy. The continued development of electronic flexible ureteroscopy and assistive technologies has led to further advances in the diagnosis of UTUC. Ureteroscopic laser ablation can be used to treat low grade malignancy, renal insufficiency, or isolated kidney. However, the use of URS may have potential risks such as delay of radical treatment, increased surgical difficulty, intraoperative or postoperative complications and intravesical recurrence. This article reviews the advantages and disadvantages of ureteroscopy in the diagnosis and treatment of UTUC.

Effects of preoperative ureteroscopy on intravesical recurrence after radical nephroureterectomy of upper tract urothelial carcinoma / 现代泌尿外科杂志

【Objective】 To investigate the effects of preoperative ureteroscopy (URS) on the intravesical recurrence (IVR) in patients with upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU). 【Methods】 The clinical data of 241 UTUC patients treated during May 2012 and Jan.2020 in the Second Hospital of Laozhou University were retrospectively analyzed. The patients were divided into URS before RNU group (URS group) and non-URS before RNU group (non-URS group). The cumulative IVR rate, progression-free survival (PFS) and overall survival (OS) after RNU were compared, and the survival curve was drawn. Cox proportional hazards models were used to assess risk factors affecting IVR. 【Results】 Of the 241 patients, 64 (26.6%) were included in the URS group and 177 (73.4%) in the non-URS group. In the URS group, 49 underwent biopsy and 15 did not. All patients were followed up for a median of 44 (3 to 122) months, with a median time to recurrence of 12 (3 to 56) months. IVR occurred in 18 patients (28.1%) in the URS group and 25 (14.1%) in the non-URS group. Kaplan-Meier survival analysis showed that the cumulative IVR rate was higher in the URS group than in the non-URS group (all P<0.05), regardless of whether patients had a history of bladder cancer (BC) or not, while PFS was lower in the URS group than in the non-URS group (P=0.007). Cox multivariate regression analysis showed that URS (P=0.031) and complicated renal pelvis tumor and ureteral tumor (P=0.004) were independent risk factors for IVR. 【Conclusion】 Preoperative URS increases the incidence of IVR in patients with UTUC, and routine preoperative use of URS is not recommended.

Research progress of intravesical recurrence after radical resection of upper tract urothelial carcinoma / 现代泌尿外科杂志

Urothelial carcinoma (UC) is the second most common genitourinary tumor, and upper tract urothelial carcinoma (UTUC) accounts for 5% to 10% of UC. Intravesical recurrence (IVR) occurs in 22% to 47% of patients after radical resection. This article reviews the mechanism, characteristics, related risk factors, regular bladder monitoring, diagnosis and treatment, and preventive measures of IVR, hoping to provide reference for clinical work.

Influence of strength training on physical fitness of badminton players / Influência do treinamento de força sobre a aptidão física dos jogadores de badminton / Influencia del entrenamiento de fuerza en la aptitud física de los jugadores de bádminton

ABSTRACT Introduction: Strength training uses loads greater than 75% of 1RM of the individual, being indicated for optimization of endurance and controlled muscular hypertrophy. It is believed that the performance of badminton players can be improved with this technique, due to the intrinsic benefits regarding the power of muscle contraction explosion. Objective: Verify the influences of strength training on the physical fitness of badminton players. Methods: 24 young volunteer badminton players were randomly selected and divided into experimental and control groups. The experimental group was trained with high-load training, and the experimental data was recorded with FirstBeat® before and after the experiment. Results: The action speed of the experimental group was reduced from 216.46km/h to 240.81km/h, while the release speed was increased from 293.79km/h to 364.25km/h. The release velocity was significantly improved, increasing the net velocity from 169.57km/h to 200.94km/h, while the control group showed no statistical change. Conclusion: Strength training was found to significantly improve the physical fitness of badminton players, significantly impacting the finishing abilities of badminton players. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução: O treinamento de força utiliza cargas maiores que 75% de 1RM do indivíduo, sendo indicadas para otimização de endurance e hipertrofia muscular controlada. Acredita-se que o desempenho dos jogadores de badminton possa ser aprimorado com essa técnica, devido aos benefícios intrínsecos quanto ao poder de explosão da contração muscular. Objetivo: Verificar as influências do treinamento de força sobre a aptidão física dos jogadores de badminton. Métodos: 24 jovens jogadores de badminton voluntários foram aleatoriamente selecionados e divididos em grupo experimental e grupo de controle. O grupo experimental foi treinado com treinamento de alta carga, sendo os dados experimentais registrados com FirstBeat® antes e depois do experimento. Resultados: A velocidade de ação do grupo experimental foi reduzida de 216,46km/h para 240,81km/h, enquanto a velocidade de liberação foi aumentada de 293,79km/h para 364,25km/h. A velocidade de liberação foi significativamente aprimorada, aumentando a velocidade líquida de 169,57km/h para 200,94km/h, enquanto o grupo de controle não apresentou alterações estatísticas. Conclusão: Constatou-se que o treinamento de força melhorou significativamente a aptidão física dos jogadores de badminton, impactando significativamente nas habilidades de finalização dos jogadores de badminton. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción: El entrenamiento de fuerza utiliza cargas superiores al 75% de 1RM del individuo, siendo indicado para optimización de la resistencia e hipertrofia muscular controlada. Se cree que el rendimiento de los jugadores de bádminton puede ser mejorado con esta técnica, debido a los beneficios intrínsecos en cuanto al poder de explosión de la contracción muscular. Objetivo: Verificar las influencias del entrenamiento de fuerza en la condición física de jugadores de bádminton. Métodos: 24 jóvenes jugadores voluntarios de bádminton fueron seleccionados aleatoriamente y divididos en grupo experimental y grupo control. El grupo experimental fue entrenado con entrenamiento de alta carga, y los datos experimentales fueron registrados con FirstBeat® antes y después del experimento. Resultados: La velocidad de acción del grupo experimental se redujo de 216,46km/h a 240,81km/h, mientras que la velocidad de liberación aumentó de 293,79km/h a 364,25km/h. La velocidad de liberación mejoró significativamente, aumentando la velocidad neta de 169,57km/h a 200,94km/h, mientras que el grupo de control no mostró cambios estadísticos. Conclusión: Se constató que el entrenamiento de fuerza mejoró significativamente la aptitud física de los jugadores de bádminton, impactando significativamente en las habilidades de remate de los jugadores de bádminton. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

Induction of peripheral blood mononuclear cells to hepatocyte-like cells and preliminary study of cell response to injury under the effect of acetaminophen / 中华肝脏病杂志

Objective: To establish a method for the induction of peripheral blood mononuclear cells to hepatocyte-like cells, and preliminarily investigate cell response to injury under the effect of acetaminophen (APAP). Methods: The surface marker CD45 of peripheral blood mononuclear cells wase detected cells by using flow cytometry and immunofluorescence methods. The cellular morphology of induced hepatocyte-like cells was observed under an inverted microscope. Real-time fluorescent quantitative PCR (RT-PCR) was used to detect the expression level of hepatocyte-specific genes, such as cytochrome (CY) P1A2, CYP3A4, CYP2C9, albumin (ALB), alpha-fetoprotein (AFP), and hepatocyte nuclear factor (HNF)4α mRNA. Immunofluorescence method was used to detect intracellular hepatocyte markers AFP, HNF4α, and ALB expression at the protein level. Biochemical analyzer was used to detect hepatocyte-specific secretory functions of AFP, ALB, and urea. Luciferase chemiluminescence method was used to detect the activity of key drug metabolizing enzyme CYP3A4. Colorimetric assay was used to detect the effect of the drug acetaminophen on hepatocyte-like cells, and alanine aminotransferase (ALT) was used as an indicator of liver cell injury. The statistical differences between the data were compared with t-test and rank-sum test. Results: The positive expression rate of CD45 cell surface markers isolated from peripheral blood mononuclear cells was about 98%, and hepatocyte-like cell morphology changes appeared on 15th day of induction. Compared with isolated mononuclear cells, CYP1A2, CYP3A4, CYP2C9, ALB, AFP and HNF4α mRNA was markedly elevated. The expression level of AFP, ALB and HNF4α protein were equally increased, and the secretory function of AFP, ALB and urea were enhanced. Compared with primary hepatocytes, CYP1A2, CYP2C9, AFP, HNF4α mRNA, and CYP3A4 mRNA did not decrease. The expression levels of AFP, ALB, and HNF4α proteins in the cells did not decrease, and the secretory function of AFP, ALB, and urea did not decrease. In addition, the CYP3A4 enzyme activity produced by hepatocyte-like cells was similar to that of primary hepatocytes. Compared with hepatocyte-like cells incubated without APAP, hepatocyte-like cells incubated with APAP had higher ALT level. Under the effect of APAP, the ALT level of hepatocyte-like cells was higher than isolated mononuclear cells. Conclusion: Peripheral blood mononuclear cells can be induced into hepatocyte-like cells with partial characteristics of hepatocytes, including the activity of CYP3A4, a key enzyme of hepatocyte drug metabolism. Additionally, preliminarily ALT secretory features reflect the hepatocytes injury under the effect of acetaminophen.

Evaluation of selected photon shield and organ-based tube current modulation for organ dose reduction and image quality in head CT for infants: a phantom study / 中华放射医学与防护杂志

Objective:To compare the dose and image quality of selected photon shield (SPS) technique, organ-based tube current modulation (OBTCM) technique and the combination of these two techniques for reducing the organ dose in head CT examination for infants.Methods:Two anthropomorphic head phantoms (CIRS 1-yr-old and 5-yr-old) were scanned by using Reference mode, Reference + OBTCM mode, SPS mode and SPS + OBTCM mode, respectively. Radiation doses to the lens of the eye, the anterior of the brain, the posterior of the brain, noise level and CNR of orbit and brain in different phantoms were measured and compared by using different scanning modes.Results:Compared with Reference mode, the doses to the lens of the eye in 1-yr-old and 5-yr-old phantom decreased by (21.89 ± 0.01)% and (28.33 ± 0.34)%, respectively. In SPS mode, the reduction in doses to the lens of the eye in 1-yr-old and 5-yr-old phantom were (71.38 ± 1.30)% and (53.72 ± 2.42)%, respectively. In SPS + OBTCM mode, the reduction was (71.12 ± 2.54)% and (55.73 ± 1.90)%, respectively. There was significant difference in the noise level of orbit and brain in different phantoms under various scanning modes ( F=5.67-85.47, P< 0.05). The noise level in OBTCM mode compared with reference mode increased slightly (<1.45 HU) in various phantoms. SPS and SPS + OBTCM mode resulted in a small noise increase (<2.58 HU). There was no significant difference in CNR of different phantoms under various scanning modes ( P>0.05). Conclusions:SPS and SPS + OBTCM mode can significantly reduce the radiation dose of lens and the whole image plane in the head CT scan for infants, with maintaining the image quality.

Assessment of the predictive effect of schistosomiasis transmission risk along the Yangtze River in Hubei，China after the flood disaster in 2020 / 公共卫生与预防医学

Objective To assess the schistosomiasis transmission risk after flood disaster in Hubei Province in 2021, so as to provide a scientific basis for schistosomiasis prevention and control in corresponding areas. Methods The data pertaining to the endemic situation of schistosomiasis were collected from Hubei, including oncomelania snail distribution, and humans and livestock schistosomiasis infection. The warning water level and actual water situation were collected in corresponding water areas. The cumulative numbers of S. japonicum egg-positive people and cattle from 2014 to 2020, the distribution area of oncomelania snail in 2020, and the water levels from May 1 to August 31, 2021, were estimated and employed as parameters for classification of schistosomiasis transmission risk. The cumulative value of each risk index was calculated in each epidemic county (city and district) to comprehensively assess the risk of schistosomiasis transmission after flood disaster in each region. Results After the flood disaster in Hubei province in 2021, there were 2 counties (districts) at high risk of schistosomiasis transmission in Hubei based on the single risk index of fecal positive number. Based on comprehensive risk indices, there were 2 counties identified at grade 4 risk of schistosomiasis transmission. Conclusion After the flood in 2021, schistosomiasis in Hubei Province is mainly at low and medium epidemic risk. Xiantao City and Hanchuan City in Hanjiang River Basin are the two most seriously affected schistosomiasis epidemic cities. Flood disasters can increase the risk of schistosomiasis transmission and epidemic, so the monitoring and control of schistosomiasis after flood should be strengthened to control the disease transmission to the maximum extent.

Overexpression of Protein Phosphatase 2 Regulatory Subunit B"Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma / 生物医学与环境科学（英文）

Objective@#To investigate the regulatory relationship of Protein Phosphatase 2 Regulatory Subunit B"Alpha ( PPP2R3A) and hexokinase 1 ( HK1) in glycolysis of hepatocellular carcinoma (HCC).@*Methods@#In HepG2 and Huh7 cells, PPP2R3A expression was silenced by small interfering RNA (siRNA) and overexpression by plasmid transfection. The PPP2R3A-related genes were searched by RNA sequencing. Glycolysis levels were measured by glucose uptake and lactate production. QRT-PCR, ELISA, western blot and immunofluorescence assay were performed to detect the changes of PPP2R3A and HK1. Cell proliferation, migration and invasion assay were used to study the roles of HK1 regulation by PPP2R3A.@*Results@#RNA sequencing data revealed that PPP2R3A siRNA significantly downregulated the expression of HK1. PPP2R3A gene overexpression promotes, while gene silencing suppresses, the level of HK1 and glycolysis in HCC cells. In HCC tissue samples, PPP2R3A and HK1 were colocalized in the cytoplasm, and their expression showed a positive correlation. HK1 inhibition abrogated the promotion of glycolysis, proliferation, migration and invasion by PPP2R3A overexpression in liver cancer cells.@*Conclusion@#Our findings showed the correlation of PPP2R3A and HK1 in the glycolysis of HCC, which reveals a new mechanism for the oncogenic roles of PPP2R3A in cancer.

Construction of an air quality health index for pediatric respiratory diseases in Shanghai / 环境与职业医学

Background Air quality health index (AQHI) has been widely used to quantify the health effects of multiple pollutants observed in population-based epidemiological studies, and can better reflect the widespread linear non-threshold between air pollution and health effects. Objective To explore an AQHI for pediatric respiratory diseases (AQHIr) in Shanghai and evaluate its feasibility. Methods The daily numbers of hospital outpatient visits for pediatric respiratory diseases from 2015 to 2019 were obtained from five general hospitals in Xuhui, Baoshan, Hongkou, Jinshan, and Chongming Districts of Shanghai. Monitoring data on air pollutants (PM2.5, PM10, SO2, NO2, and O3), air quality index (AQI), and meteorological variables (temperature, relative humidity, air pressure, and wind speed) were collected from five air quality monitoring sites nearest to selected hospitals. Time-series analysis using generalized additive model (GAM) was conducted to estimate the associations between respiratory-related pediatric outpatient visits and the concentrations of air pollutants. The sum of excess risk (ER) of hospital outpatient visits was used to construct AQHIr. To assess the predictive power of AQHIr, the associations of AQHIr and AQI with the number of pediatric respiratory outpatient visits in three hospitals in Xuhui, Hongkou, and Chongming districts were compared. Results Air pollutants had various effects on respiratory diseases outpatient visits. PM2.5, NO2, and O3 had most significant impacts on lag0 day and the associated ERs of hospital outpatient visits for each 10 μg·m−3 increase in pollutant concentration were 1.27% (95%CI: 0.88%-1.66%), 0.75% (95%CI: 0.40%-1.11%), and 0.36% (95%CI: 0.10%-0.62%), respectively. PM10 and SO2 had most significant impacts on lag3 day and the associated ERs of hospital outpatient visits for each 10 μg·m−3 increase in pollutant concentration were 0.81% (95%CI: 0.51%-1.12%) and 5.64% (95%CI: 3.37%-7.96%), respectively. There were significant effects of combinations of two pollutants among PM2.5, PM10, NO2, SO2, and O3 except for PM10+NO2, SO2+PM2.5, and SO2+NO2 (P<0.05). According to the results of single-pollutant and two-pollutant models, PM2.5, NO2, SO2, and O3 were selected to construct AQHIr. The comparison showed that for every interquartile range increase in AQHIr, the ER for pediatric outpatient visits was higher than that for the value corresponding to AQI. Conclusion Air pollutants in Shanghai have an impact on the number of pediatric respiratory outpatient visits. The AQHIr based on and outpatient visits for pediatric respiratory diseases can be a sensitive index to predict the effects of air pollution on children's respiratory health.

Sexual and reproductive health knowledge and practice among students in six senior high schools in three regions in East China / 上海预防医学

Objective:To know the status of knowledge， attitude and behavior related to sexual and reproductive health in high school students in three regions of East China， and to provide a reference for adolescent reproductive health education. Methods:From August to October in 2019， 614 high school students were invited from 6 high schools in Jiading District and Yangpu District， Shanghai and Taicang City， Jiangsu to participate in this study. We conducted an anonymous self-questionnaire survey using structured questionnaires based on adolescent reproductive health knowledge and literacy. Results:The male to female ratio of all high school students in the study was 1∶1.25， and the average age was （16.1±0.9） years old. The score of pregnancy and abortion knowledge was the lowest among the reproductive health knowledge scores， and the differences among the three regions were statistically significant （P=0.002）. Male high school students （P<0.001）， students in the school with reproductive health education base （P=0.008） and students who wanted to obtain reproductive health education （P=0.002） were more acceptable to premarital sex. The high school students obtained adolescent health knowledge mainly through the internet or mobile phones， and had a demand for reproductive health related services. Conclusion:High school students in the three regions have a more open attitude towards premarital sex， but have a poor grasp of correct and efficient contraceptive knowledge. Responsible departments need to strengthen the health education of relevant knowledge， and at the same time to find new forms of education to effectively improve the level of adolescent reproductive health.

Optimal design of blade in pump as turbine based on multidisciplinary feasible method.

In order to make the pump as turbine (PAT) run efficiently and safely, a multidisciplinary optimization design method for PAT blade, which gives consideration to both the hydraulic and intensity performances, is proposed based on multidisciplinary feasibility (MDF) optimization strategy. This method includes blade parametric design, Latin Hypercube Sampling (LHS) experimental design, CFD technology, FEA technology, GA-BP neural network and NSGA-II algorithm. Specifically, a parameterized PAT blade with cubic non-uniform B-spline curve is adopted, and the control point of blade geometry is taken as the design variable. The LHS experimental design method obtains the sample points of training GA-BP neural network in the design space of variables. The hydraulic performance of each sample point (including the hydraulic pressure load on the blade surface) and the strength performance analysis of blades are completed by CFD and FEA technology respectively. In order to save calculation time of the whole optimization design, the multi-disciplinary performance analysis of each sample in the optimization process is completed by single-coupling method. Then, GA-BP neural network is trained. Finally, the multi-disciplinary optimization design problem of PAT blade is solved by the optimization technology combining GA-BP neural network and NSGA-II algorithm. Based on this optimization method, the PAT blade is optimized and improved. The efficiency of the optimized PAT is improved by 1.71% and the maximum static stress on the blade is reduced by 7.98%, which shows that this method is feasible.

Large-scale single-cell analysis reveals critical immune characteristics of COVID-19 patients

Dysfunctional immune response in the COVID-19 patients is a recurrent theme impacting symptoms and mortality, yet the detailed understanding of pertinent immune cells is not complete. We applied single-cell RNA sequencing to 284 samples from 205 COVID-19 patients and controls to create a comprehensive immune landscape. Lymphopenia and active T and B cell responses were found to coexist and associated with age, sex and their interactions with COVID-19. Diverse epithelial and immune cell types were observed to be virus-positive and showed dramatic transcriptomic changes. Elevation of ANXA1 and S100A9 in virus-positive squamous epithelial cells may enable the initiation of neutrophil and macrophage responses via the ANXA1-FPR1 and S100A8/9-TLR4 axes. Systemic upregulation of S100A8/A9, mainly by megakaryocytes and monocytes in the peripheral blood, may contribute to the cytokine storms frequently observed in severe patients. Our data provide a rich resource for understanding the pathogenesis and designing effective therapeutic strategies for COVID-19. HIGHLIGHTSO_LILarge-scale scRNA-seq analysis depicts the immune landscape of COVID-19 C_LIO_LILymphopenia and active T and B cell responses coexist and are shaped by age and sex C_LIO_LISARS-CoV-2 infects diverse epithelial and immune cells, inducing distinct responses C_LIO_LICytokine storms with systemic S100A8/A9 are associated with COVID-19 severity C_LI

Liver inflammation and oxidative damage induced by subchronic crotonaldehyde exposure in male rats / 中国职业医学

OBJECTIVE: To investigate the hepatotoxicity induced by subchronic crotonaldehyde exposure in male rats and analyze its possible mechanism. METHODS: The specific pathogen-free male Wistar rats were randomly divided into control group, low-, medium-and high-dose crotonaldehyde groups, with 10 rats in each group. The crotonaldehyde solution at doses of 0.0, 2.5, 4.5, and 8.5 mg/kg body weight were given by intragastric administration, once a day, 5 days per week, and continuous for 90 days. The body weight of the rats were weighed during the exposure period. After the exposure, the liver organ coefficients and histopathological changes of the rats were observed. The activities of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) and the level of total bilirubin(TBIL) in the serum of rats were determined by colorimetry. The levels of malondialdehyde(MDA) and reduced glutathione(GSH), and the activities of glutathione peroxide(GSH-Px) and superoxide dismutase(SOD) were determined by colorimetry. The levels of interleukin(IL)-1β, IL-6, tumor necrosis factor alpha(TNF-α) and interferon-γ(IFN-γ) was detected by enzyme-linked immunosorbent assay. RESULTS: At the end of exposure, the increment of body mass of rats in the low-, medium-and high-dose crotonaldehyde groups was lower than that in the control group(P<0.05). The organ coefficients of rats in the middle-and high-dose groups were lower than that in the control group(P<0.05). The liver tissues of the three doses crotonaldehyde groups showed varying degrees of inflammatory cell infiltration. The activities of ALT, AST and the level of TBIL in the serum of rats increased with the increase of the crotonaldehyde exposure dose(P<0.01). With the increase of the crotonaldehyde dose, the level of MDA in rat liver tissue increased(P<0.01), and the level of GSH and the activities of GSH-Px and SOD decreased(P<0.01). The levels of IL-1β, IL-6, TNF-α and IFN-γ in rat liver tissues increased(P<0.05). CONCLUSION: Crotonaldehyde exposure can cause liver tissue damage in rats. Its mechanism of action may be related to the changes of oxidative balance and upregulation of the expression of inflammatory factors in liver tissue. These changes have the dose-effect relationship.

Frequency Characteristics of AEPs in Normal Young Adults and Comparison of Their Response Threshold and Pure Tone Audiometry Threshold / 法医学杂志

Objective The tests of three types of auditory evoked potentials （AEPs） were performed on normal young adults, to understand the frequency characteristics of different testing methods and the relationship between response threshold and pure tone audiometry threshold of different methods, and to discuss the forensic value of 3 types of AEPs to evaluate hearing function. Methods Twenty normal young adults were selected, their standard pure tone audiometry threshold, short-term pure tone audiometry threshold and the response threshold of 3 types of AEPs （tone burst-auditory brainstem response, 40 Hz auditory event-related potential and slow vertex response） at 0.5 kHz, 1.0 kHz, 2.0 kHz and 4.0 kHz were recorded. The relationship between the response threshold and standard pure tone audiometry threshold, short-term pure tone audiometry threshold of 3 types of AEPs at different frequencies as well as the differences between different types of AEPs were analyzed. Results The short-term pure tone audiometry threshold was higher than the standard pure tone audiometry threshold at each frequency. The response threshold and standard pure tone audiometry threshold of the 3 types of AEPs all had a certain correlation, and the response threshold of the 3 types of AEPs was higher than short-term pure tone audiometry threshold and standard pure tone audiometry threshold at each frequency. The differences in the differences between the response threshold and standard pure tone audiometry threshold of the 3 types of AEPs at different frequencies had statistical significance. Linear regression mathematical models were established to infer the standard pure tone audiometry threshold （hearing level） from response threshold （sound pressure level） of 3 types of AEPs of normal young adults. Conclusion When using response threshold of different types of AEPs to estimate pure tone audiometry threshold, conversion and correction are needed. Combined use of different types of AEPs could improve the accuracy of hearing function evaluation.

Research progress on suicide of schizophrenia patients / 上海交通大学学报（医学版）

Suicide refers to the act of voluntarily and actively ending one's life. Schizophrenia is a serious mental illness with a high risk of suicide, which has a great impact on individuals and families. Suicide is the most important cause of premature death in schizophrenia patients. The paper reviews recent advances in suicide-related risk factors, suicidal characteristics of patients with different characteristics, and suicide intervention in schizophrenia patients.

Self-made one-fourth tubular hook plate for fixation of comminuted fractures of acetabular posterior wall / 中华创伤骨科杂志

Objective@#To observe the clinical efficacy of self-made one-fourth tubular hook plate used in the fixation of comminuted fractures of acetabular posterior wall.@*Methods@#The clinical data of 21 patients with comminuted fracture of acetabular posterior wall were retrospectively analyzed who had been treated by fixation with our self-made one-fourth tubular hook plate from June 2015 to September 2017 at Deparment I of Orhthopaedics, The Second People's Hospital of Anhui Province. They were 12 males and 9 females, aged from 20 to 59 years (mean, 38.5 years). The time from injury to surgery ranged from 3 to 6 days (average, 4.5 days). All the fractures were fixated with our self-made one-fourth tubular hook plate via the Kocher-langenbeck approach. Depending on the fracture fragments, the hook plate was cut out obliquely through the 3rd or 4th hole and the sharp end of the plate was bent into a small hook to hold the fragments. Only the hook plate was used in 6 cases and an additional construction plate in the other 15 cases. The postoperative reduction, functional recovery of the affected hip and complications were recorded.@*Results@#The follow-up averaged 13 months (from 8 to 32 months). Intermuscular venous thrombosis occurred in one patient and sciatic nerve contusion was observed intraoperatively in one patient with sciatic nerve injury. According to the improved Matta criteria, the fracture reduction was rated as excellent in 16 cases, as good in 4 and as poor in one, giving a good to excellent rate of 95.2%. The fractures united after an average of 7.5 months (from 6 to 12 months). According to the improved Merle d'Aubigné and Postel scoring system, the hip function at the final follow-up was excellent in 14 cases, good in 3, fair in 2 and poor in 2, giving a good to excellent rate of 81.0%. Follow-ups revealed traumatic arthritis in 3 cases, femoral head necrosis in 2 cases and ectopic ossification in one.@*Conclusion@#Our self-made one-fourth tubular hook plate is simple, economical and effective because it can provide easy and rigid fixation of the comminuted fractures of acetabular posterior wall, leading to fine therapeutic effects.

Study on lung injury induced by subchronic exposure to crotonaldehyde in male rats / 中华劳动卫生职业病杂志

Objective@#To observe the lung injury of male rats induced by sub-chronic exposure to crotonaldehyde, and to explore the possible mechanism of injury.@*Methods@#Forty SPF male Wistar rats were randomly divided into control group and 3 groups in each group, and each group received 0.0, 2.5, 4.5, 8.5 mg/kg body weight crotonaldehyde solution for continuous intragastric administration. 120 d, once a day. After the end of the exposure, the body weight of the rats was measured, and the lung tissues were quickly separated after cervical dislocation. The organ coefficients were calculated and histopathological examination was performed to determine malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione. Peroxidase (GSH-Px) content; ELISA was used to measure interleukin (IL) -6, IL-1β, and tumor necrosis factor (TNF) -α in lung tissues.@*Results@#Compared with the control group, the weight gain of the rats in the 4.5 and 8.5 mg/kg exposure groups was small, and the lung weight and organ coefficient of the exposed group decreased, the difference was statistically significant (P<0.05). In the exposed group, the lung tissue structure was disordered, the alveolar wall was thickened, and inflammatory cell infiltration was observed. Compared with the control group, the MDA activity in the serum of the rats in the 4.5 mg/kg and 8.5 mg/kg groups increased, and the SOD and GSH-Px activities decreased, the difference was statistically significant (P<0.05). TNF-α levels in the lung tissues of rats exposed to 4.5 mg/kg and 8.5 mg/kg, and levels of (IL) -6 and IL-1β in the lungs of rats in the 2.5, 4.5, and 8.5 mg/kg groups. Significantly increased, the difference was statistically significant (P<0.05) .@*Conclusion@#Crotonaldehyde may induce inflammatory and oxidative stress damage in rats by up-regulating the expression of inflammatory factors in lung tissue and changing the oxidative balance.

Self-made one-fourth tubular hook plate for fixation of comminuted fractures of acetabular posterior wall / 中华创伤骨科杂志

Objective To observe the clinical efficacy of self-made one-fourth tubular hook plate used in the fixation of comminuted fractures of acetabular posterior wall.Methods The clinical data of 21 patients with comminuted fracture of acetabular posterior wall were retrospectively analyzed who had been treated by fixation with our self-made one-fourth tubular hook plate from June 2015 to September 2017 at Deparment I of Orhthopaedics,The Second People's Hospital of Anhui Province.They were 12 males and 9 females,aged from 20 to 59 years (mean,38.5 years).The time from injury to surgery ranged from 3 to 6 days (average,4.5 days).All the fractures were fixated with our self-made one-fourth tubular hook plate via the Kocher-langenbeck approach.Depending on the fracture fragments,the hook plate was cut out obliquely through the 3rd or 4th hole and the sharp end of the plate was bent into a small hook to hold the fragments.Only the hook plate was used in 6 cases and an additional construction plate in the other 15 cases.The postoperative reduction,functional recovery of the affected hip and complications were recorded.Results The follow-up averaged 13 months (from 8 to 32 months).Intermuscular venous thrombosis occurred in one patient and sciatic nerve contusion was observed intraoperatively in one patient with sciatic nerve injury.According to the improved Matta criteria,the fracture reduction was rated as excellent in 16 cases,as good in 4 and as poor in one,giving a good to excellent rate of 95.2％.The fractures united after an average of 7.5 months (from 6 to 12 months).According to the improved Merle d'Aubigné and Postel scoring system,the hip function at the final follow-up was excellent in 14 cases,good in 3,fair in 2 and poor in 2,giving a good to excellent rate of 81.0％.Follow-ups revealed traumatic arthritis in 3 cases,femoral head necrosis in 2 cases and ectopic ossification in one.Conclusion Our self-made one-fourth tubular hook plate is simple,economical and effective because it can provide easy and rigid fixation of the comminuted fractures of acetabular posterior wall,leading to fine therapeutic effects.

Diabetes Mellitus and Cause-Specific Mortality: A Population-Based Study

BACKGROUND: To investigate whether diabetes contributes to mortality for major types of diseases. METHODS: Six National Health and Nutrition Examination Survey data cycles (1999 to 2000, 2001 to 2002, 2003 to 2004, 2005 to 2006, 2007 to 2008, and 2009 to 2010) and their linked mortality files were used. A population of 15,513 participants was included according to the availability of diabetes and mortality status. RESULTS: Participants with diabetes tended to have higher all-cause mortality and mortality due to cardiovascular disease, cancer, chronic lower respiratory diseases, cerebrovascular disease, influenza and pneumonia, and kidney disease. Confounder-adjusted Cox proportional hazard models showed that both diagnosed diabetes category (yes or no) and diabetes status (diabetes, prediabetes, or no diabetes) were associated with all-cause mortality and with mortality due to cardiovascular disease, chronic lower respiratory diseases, influenza and pneumonia, and kidney disease. No associations were found for cancer-, accidents-, or Alzheimer's disease-related mortality. CONCLUSION: The current study's findings provide epidemiological evidence that diagnosed diabetes at the baseline is associated with increased mortality risk due to cardiovascular disease, chronic lower respiratory diseases, influenza and pneumonia, and kidney disease, but not with cancer or Alzheimer's disease.