RESUMO
Ascorbic acid and selenium are important antioxidants for the reactive forms of oxygen. The purpose of these experiments was to determine the influence of various concentrations of cadmium on ascorbic acid and selenium concentrations in certain tissues of rats. The results showed that cadmium, added to rats' feed, influenced the concentration of ascorbic acid in blood serum and tested rats' tissues. Cadmium influenced the concentration of selenium in certain tissues as well. Furthermore, it has been demonstrated that ascorbic acid and selenium concentrations are dependent on the type of tissue tested as well as on the size of cadmium concentrations and length of the experiments.
Assuntos
Ácido Ascórbico/sangue , Intoxicação por Cádmio/sangue , Selênio/sangue , Animais , Cádmio/farmacocinética , Cádmio/toxicidade , Relação Dose-Resposta a Droga , Masculino , Ratos , Ratos Wistar , Fatores de Tempo , Distribuição TecidualRESUMO
Zinc and copper, administered to the organism in excess can also influence the concentrations of other elements, and have a secondary influence on the processes that these elements regulate. The purpose of this experiment was to determine the influence of zinc and copper dietary supplementation on the concentrations of magnesium, calcium, zinc and copper in the rat's skin. The results showed that zinc supplementation caused a decrease in calcium concentration as well as an increase in zinc concentration in the tested materials. The concentrations of magnesium and copper changed insignificantly. Copper supplementation caused a decrease in the concentration of magnesium, calcium and zinc but caused an increase in copper concentration. Changes in concentrations of the tested metals were dependent upon the concentrations of various metals added to the rat's diets.