[The potentials of heparin monotherapy in patients with hemorrhagic vasculitis and kidney involvement]. / Mozhlyvosti monoterapiï heparynom khvorykh na hemorahichnyi vaskulit z urazhenniam nyrok.

A retrospective analysis was done of case histories and outpatient case records of 25 patients with hemorrhagic vasculitis presenting with renal lesion, and 12 patients with hemorrhagic vasculitis without kidney damage. Heparin therapy was instituted as subcutaneous injections 4 times daily, 450-500 units/kg/24 h. A positive effect of heparin therapy correlated with the early start of the treatment and presence of the urinary syndrome. A possibility is shown of forecasting of the heparin therapy efficacy in the above patient populations in respect of a decline in the urinary excretion of products of the fibrinogen/fibrin cleavage more than two-fold a week after the start of treatment. If no such decline occurs the treatment is to be supplemented by prednizolon and curantil.

[The efficacy of kurantil and its effect on thrombocytic hemostasis in patients with chronic glomerulonephritis]. / Efektyvnist' kurantylu ta ioho vplyv na trombotsytarnyi hemostaz u khvorykh na khronichnyi hlomerulonefryt.

The paper treats of the mechanisms of antiaggregant and vasoactive effect of curantyl (C) in chronic glomerulonephritis (ChGN). As many as 85 ChGN C-treated patients were examined; positive treatment effect was seen in 35.5%, negative one in 12.9% of the patients; no effect in 25.8%. It has been ascertained that in some instances prognostically unfavourable forms of ChGN do respond to C treatment. Efficacy of C therapy is predictable from the baseline 24 h proteinuria and decrease in urinary excretion of products of fibrinogen/fibrin degradation during the first week of treatment.