[Granular cell tumor. Epidemiology of 263 cases]. / La tumeur à cellules granuleuses. Epidémiologie de 263 cas.

263 cases of granular cell tumour had collected [thanks to the collaboration of pathologists Septentrional Association of North, Pas-de-Calais and Aisne departments (A.S.A.P.)]. We studied the age, sex, localisations and the particularity of these tumours. These results had compared to other large series of the literature. Our study showed a majority of men (68%), twenty to sixty year old. The preferential sites are skin (38.57%), oesophagus (19.64%) and tongue (10%). The granular cell tumour is multiple in fifteen cases and associated to neoplastic tumour in twelve cases. Only one case recurred after incomplete excision. There were none malignant tumour.

[Granular cell tumor and congenital epulis. Histochemical and immunohistochemical of 58 cases]. / Tumeur à cellules granuleuses et épulis congénitale. Etude histochimique et immunohistochimique de 58 cas.

56 cases of granular cell tumour and 2 cases of granular cell congenital epulis have been studied morphologically, histochemically and immunohistochemically. The subject of this study is to evaluate the diagnosis interest of the PAS stain, determine the positivity of 4 antibodies (vimentin, NSE, PS100, NK1/C3) and confirm or not the neuroectodermic origin. The study showed that the microscopic findings are often sufficient. When the diagnosis is less evident, the PAS stain is not discriminant, but we can use the immunohistochemistry study: we confirmed the positivity of the 4 antibodies, but PS100 and NK1/C3 are the most constant. Only the 2 cases of granular cell congenital epulis always show negative immunoreactivity with S100 protein. About the histogenesis, our study confirm the neurogenic origin, but the hypothesis of a non neoplastic nature is raised.