RESUMO
Inflammatory genital cutaneous involvement of Crohn's disease is a rare complication. In a 23 year old man, who had colonic Crohn's disease treated by colectomy 3 years earlier, a phimosis revealed a penile localisation of Crohn's disease. "Metastatic" locations of Crohn's disease are defined by granulomas sitting at a distance from the injured bowel. Their clinical manifestations are misleading and their course is independent of the digestive disease. In our patient, after failure of classical therapy, cyclosporin A permitted a slow regression.
Assuntos
Doença de Crohn/patologia , Granuloma/patologia , Doenças do Pênis/patologia , Adulto , Colectomia , Terapia Combinada , Doença de Crohn/tratamento farmacológico , Doença de Crohn/cirurgia , Ciclosporina/uso terapêutico , Granuloma/tratamento farmacológico , Humanos , Masculino , Doenças do Pênis/tratamento farmacológico , Indução de Remissão/métodosRESUMO
Malignant mesothelioma of the tunica vaginalis, a rare tumour, affects men over the age of 50 years and presents in the form of a testicular mass. It is rarely suspected preoperatively and the diagnosis is suggested by the presence of numerous nodules in the tunica vaginalis. This tumour has a high metastatic potential and raises the problem of numerous local recurrences. The diagnosis is histological with negative biological markers. Treatment is difficult; the first step must consist of surgery. The indications for radiotherapy have yet to be defined.
Assuntos
Mesotelioma , Neoplasias Testiculares , Idoso , Idoso de 80 Anos ou mais , Humanos , Masculino , Mesotelioma/patologia , Mesotelioma/terapia , Neoplasias Testiculares/patologia , Neoplasias Testiculares/terapiaAssuntos
Conjuntivite/diagnóstico , Doenças Palpebrais/diagnóstico , Adulto , Diagnóstico Diferencial , Humanos , Masculino , SíndromeRESUMO
Alveolar soft part sarcoma occurs mostly in the deep soft tissues. An unusual case of primary pulmonary alveolar soft part sarcoma is reported. A 39-year-old woman presented with thoracic pain revealing the tumor. The left lower lobe was surgically resected. The microscopic features of this tumor, including characteristic alveolar pattern and the PAS-positive crystals were typical of alveolar soft part sarcoma. Immunohistochemically, granular cytoplasmic reactivities were observed with antibodies against vimentin, myoglobin, methionine-enkephalin, S100 protein and neuron-specific-enolase. Electron microscopic study demonstrated numerous crystallized structures in the tumor cell cytoplasm. This is the third case of pulmonary alveolar soft part sarcoma, one arising from the pulmonary vein. The histogenesis of alveolar soft part sarcoma is still debated. Our case does not allow distinction between myogenic or neural origin of this tumor.
Assuntos
Neoplasias Pulmonares/patologia , Sarcoma Alveolar de Partes Moles/patologia , Adulto , Feminino , Humanos , Imuno-Histoquímica , Neoplasias Pulmonares/química , Sarcoma Alveolar de Partes Moles/químicaRESUMO
OBJECTIVE: To assess endothelial cell activation in patients with systemic sclerosis (SSc). METHODS: Concomitant study of salivary gland biopsy tissues and sera for expression of E-selectin and its potent activator tumor necrosis factor alpha (TNF alpha), using immunostaining and enzyme-linked immunosorbent essay. RESULTS: E-selectin was overexpressed in SSc patients, but not in controls. TNF alpha was detected in mast cells. CONCLUSION: Mast cell-derived TNF alpha may contribute to endothelial cell activation in SSc.