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1.
Reprod Toxicol ; 32(3): 261-7, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21736938

RESUMO

Arctic is contaminated with persistent organochlorine pollutants (POPs), and exposure to these compounds may differ between south and north in Norway. POPs may have negative impact on male reproductive characteristics. We compared serum levels of the CB-153 and p,p'-DDE in men who were born and had lived most of their lifetime south and north (close to or above the Arctic Circle) in Norway. We found no geographical differences in levels of CB-153 (south: 50 ng/g lipid (mean), north: 59 ng/g lipid; p=0.27) or sperm parameters. However, the levels of p,p'-DDE were higher in south than in north (81 ng/g lipid (mean) vs. 66 ng/g lipid; p=0.02), as were the levels of total and free testosterone. The FSH levels were lowest in south. A strong relationship between the CB-153 and the SHBG levels was observed. The regional differences observed for p,p'-DDE, testosterone and FSH were not reflected in the semen quality.


Assuntos
Diclorodifenil Dicloroetileno/sangue , Poluentes Ambientais/sangue , Bifenilos Policlorados/sangue , Globulina de Ligação a Hormônio Sexual/metabolismo , Adulto , Monitoramento Ambiental , Estradiol/sangue , Hormônio Foliculoestimulante/sangue , Humanos , Inibinas/sangue , Hormônio Luteinizante/sangue , Masculino , Noruega , Reprodução , Contagem de Espermatozoides , Motilidade dos Espermatozoides , Testosterona/sangue , Adulto Jovem
2.
Asian J Androl ; 11(6): 723-30, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19823177

RESUMO

It is generally thought that a single ejaculate is a bad predictor of semen quality of a subject, because of significant intra-individual variation. Therefore, we investigated the degree to which the results of a first semen analysis differ from that of a second analysis among men from a general population in Norway. In addition, we analysed how the two different semen results mirrored the overall semen quality assessment. A total of 199 volunteers participated in the study and delivered two semen samples with an interval of 6 months. The semen parameters were determined according to the World Health Organization (WHO) 1999 guidelines, which were also used to determine whether semen quality was normal or abnormal. In addition, the DNA fragmentation index (DFI) was determined using the Sperm Chromatin Structure Assay. The two samples from each individual were very similar with regard to standard semen parameters and DFI (r(s:) 0.67-0.72), and there were no significant systematic differences between the two samples. The result of the first sample (normal/abnormal) was highly predictive of the overall conclusion based on the two samples (sperm concentration: in 93% of the cases (95% confidence interval [CI]: 89%-96%); sperm motility: in 85% of the cases (95% CI: 79%-89%); overall semen quality: in 85% of the cases (95% CI: 80%-90%). In epidemiological studies, one ejaculate is a sufficient indicator of semen quality in a group of subjects. In a clinical situation, when the question is whether the semen quality is normal or not, the first ejaculate will, in at least 85% of cases, give a correct overall conclusion.


Assuntos
Análise do Sêmen , Fragmentação do DNA , Humanos , Masculino , Reprodutibilidade dos Testes , Motilidade dos Espermatozoides
3.
Clin Endocrinol (Oxf) ; 67(1): 85-92, 2007 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-17547693

RESUMO

OBJECTIVE: Seasonal variation in photoperiod or temperature may influence human reproductive biology. The present study evaluated whether seasonal changes occurred in the levels of reproductive hormones and the major melatonin metabolite, 6-sulfatoxymelatonin (aMT6s), in populations exposed to extreme variation in photoperiod and temperature. DESIGN: Two separate cohorts of Norwegian men were recruited from the general population in either of two locations: Tromsø (69.5 degrees N, n = 92) or Oslo (60 degrees N, n = 112), located north and south of the Arctic Circle (66.5 degrees N), respectively. MEASUREMENTS: Four blood and 12-h overnight urine samples were obtained on separate occasions over a 12-month period, including during the photoperiod maximum and minimum. Serum concentrations of FSH, LH, testosterone (T), oestradiol (E(2)), SHBG and the urinary excretion of aMT6s were assessed. RESULTS: Statistical analysis using generalized estimating equations indicated that LH levels were lowest during early winter in both locations (both P = 0.01). In Tromsø, free T and E(2) concentrations peaked during early winter (P = 0.02 and 0.003, respectively). In Oslo, free T levels were lowest during early winter (P = 0.06) whereas E(2) levels were lowest during late summer (P < 0.001). Urinary aMT6s concentrations were lowest during early summer in Tromsø and Oslo. Concentrations peaked during early winter in Tromsø (P < 0.001) and during late winter in Oslo (P < 0.001). CONCLUSIONS: LH levels exhibited similar changes in both locations, whereas the patterns of changes of the sex steroid concentrations differed, possibly indicating different underlying mechanisms. Excretion of aMT6s was lowest during early summer in both locations, indicating that the long natural photoperiod was sufficient to cause suppression of melatonin secretion. Whether these changes have any biological significance remains uncertain.


Assuntos
Hormônios Esteroides Gonadais/sangue , Melatonina/análogos & derivados , Estações do Ano , Adulto , Regiões Árticas , Biomarcadores/sangue , Biomarcadores/urina , Estradiol/sangue , Hormônio Foliculoestimulante/sangue , Humanos , Hormônio Luteinizante/sangue , Masculino , Melatonina/urina , Noruega , Fotoperíodo , Estudos Prospectivos , Globulina de Ligação a Hormônio Sexual/análise , Testosterona/sangue
4.
J Clin Endocrinol Metab ; 89(9): 4397-402, 2004 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-15356037

RESUMO

Seasonal, daylight-dependent variation in human spermatozoa counts, with lowest values during summer, has been suggested. To test this hypothesis, we performed a longitudinal study of semen quality and reproductive hormone levels in Norwegian men living north and south of the Arctic Circle. An ejaculate and a serum specimen were obtained both in summer and in winter from 92 volunteers in Tromsoe (69 degrees north latitude) and 112 in Oslo (60 degrees north latitude). Semen analyses were performed, and serum was assayed for FSH and inhibin B. The median spermatozoa concentration in Tromsoe after adjustment for abstinence period length was 49 x 10(6)/ml in summer and 54 x 10(6)/ml in winter. Corresponding values for Oslo were 59 x 10(6)/ml and 54 x 10(6)/ml. The seasonal differences in spermatozoa concentration were not statistically significant, nor were significant differences observed in median total spermatozoa count, semen volume, percentage progressive motile spermatozoa, or FSH. In Tromsoe, but not Oslo, inhibin B concentration was slightly, but significantly (P = 0.02) higher in winter than summer (229 ng/liter vs. 223 ng/liter). The length of the daylight period may have a slight impact on hormonal markers of spermatogenesis but does not cause substantial changes in spermatozoa numbers and motility.


Assuntos
Estações do Ano , Contagem de Espermatozoides , Motilidade dos Espermatozoides , Adulto , Regiões Árticas , Humanos , Inibinas/sangue , Luz , Estudos Longitudinais , Noruega , Espermatogênese
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