Quantum Circuits with Classically Simulable Operator Scrambling.

We introduce a new family of quantum circuits for which the scrambling of a subspace of nonlocal operators is classically simulable. We call these circuits "super-Clifford circuits" since the Heisenberg time evolution of these operators corresponds to Clifford evolution in operator space. Thus we are able to classically simulate the time evolution of certain single Pauli strings into operators with operator entanglement that grows linearly with the number of qubits. These circuits provide a new technique for studying scrambling in systems with a large number of qubits, and are an explicit counter example to the intuition that classical simulability implies the absence of scrambling.

Universal Charge Diffusion and the Butterfly Effect in Holographic Theories.

We study charge diffusion in holographic scaling theories with a particle-hole symmetry. We show that these theories have a universal regime in which the diffusion constant is given by D_{c}=Cv_{B}^{2}/(2πT), where v_{B} is the velocity of the butterfly effect. The constant of proportionality C depends only on the scaling exponents of the infrared theory. Our results suggest an unexpected connection between transport at strong coupling and quantum chaos.

Quantum critical transport and the Hall angle in holographic models.

We study the Hall conductivity in holographic models where translational invariance is broken by a lattice. We show that generic holographic theories will display a different temperature dependence in the Hall angle as to the dc conductivity. Our results suggest a general mechanism for obtaining an anomalous scaling of the Hall angle in strongly interacting quantum critical systems.

Holographic lattices give the graviton an effective mass.

We discuss the dc conductivity of holographic theories with translational invariance broken by a background lattice. We show that the presence of the lattice induces an effective mass for the graviton via a gravitational version of the Higgs mechanism. This allows us to obtain, at leading order in the lattice strength, an analytic expression for the dc conductivity in terms of the size of the lattice at the horizon. In locally critical theories this leads to a power law resistivity that is in agreement with an earlier field theory analysis of Hartnoll and Hofman.

Variability in drug metabolizing enzyme activity in HIV-infected patients.

AIMS: To evaluate variability in cytochrome P450 (CYP) 1A2, CYP2D6, CYP3A, N-acetyltransferase 2 (NAT2), and xanthine oxidase (XO) activity in HIV-infected patients and compare this with data from uninfected, healthy volunteers. METHODS: Ten HIV-infected men and seven women on medication affecting CYP enzyme activity were phenotyped four times over 2 months using caffeine, dextromethorphan, and midazolam. Urinary caffeine and dextromethorphan metabolite ratios were used to phenotype CYP1A2, NAT2, XO, and CYP2D6 activity and midazolam plasma clearance was used to phenotype CYP3A activity. Plasma and urine samples were analyzed by validated LC/UV or LC/MS methods for midazolam, caffeine, and dextromethorphan. Noncompartmental pharmacokinetics and nonparametric statistical analyses were performed, and the data compared with those of healthy volunteer historic controls. RESULTS: Compared with age and sex-matched healthy volunteers, HIV-infected subjects had 18% lower hepatic CYP3A4 activity, 90% lower CYP2D6 activity, 53% lower NAT2 activity, and 22% higher XO activity. No significant difference was found in CYP1A2 activity. Additionally, 25% genotype-phenotype discordance in CYP2D6 activity was noted in HIV-infected subjects. Intraindividual variability in enzyme activity increased by 42-62% in HIV-infected patients for CYP1A2, NAT2, and XO, and decreased by 33% for CYP2D6. Interindividual variability in enzyme activity increased by 27-63% in HIV-infected subjects for CYP2D6, CYP1A2, and XO, and decreased by 38% for NAT2. Higher plasma TNFalpha concentrations correlated with lower CYP2D6 and CYP3A4 activity. CONCLUSIONS: Infection with HIV or stage of HIV infection may alter Phase I and II drug metabolizing enzyme activity. HIV infection was related to an increase in variability of these drug-metabolizing enzymes. Altered metabolism may be a consequence of immune activation and cytokine exposure.

Distributed fiber temperature and strain sensor using coherent radio-frequency detection of spontaneous Brillouin scattering.

A novel technique that enables coherent detection of spontaneous Brillouin scattering in the radio-frequency (<500 MHz) region with excellent long-term stability has been demonstrated for distributed measurements of temperature and strain in long fiber. An actively stabilized single-frequency Brillouin fiber laser with extremely low phase noise and intensity noise is used as a well-defined, frequency-shifted local oscillator for the heterodyne detection, yielding measurements of spontaneous Brillouin scattering with high frequency stability. Based on this approach, a highly stable real-time fiber sensor for distributed measurements of both temperature and strain over long fiber has been developed utilizing advanced digital signal processing techniques.