RESUMO
The relationship between the antitryptic activity of the blood serum, bronchoalveolar secretion and ventilatory indices of the external respiration function in 85 patients with chronic bronchitis in the process of treatment is described. The above findings allow to recommend antibiotics for wide use only in exacerbations of purulent bronchitis while in other clinical variants reduction of drug loads result in increased therapeutic efficiency.
Assuntos
Bronquite/metabolismo , Inibidores de Proteases/metabolismo , Respiração , Adolescente , Adulto , Bronquite/fisiopatologia , Doença Crônica , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
The antiproteolytic activity of the blood serum was examined in the course of hospital treatment of 128 adolescents with prevailingly torpid forms of pulmonary tuberculosis and in 19 adolescents with tubercular infection (control). A direct correlation has been found between the degree of clinico-roentgenological manifestations of the disease and level of serum alpha 1-inhibitor of proteinases as well as between the efficacy of treatment and normalization of the antiproteolytic activity of the blood of the patients. It proposed to use the determination of alpha 1-inhibitor of proteinases as an additional criterion of evaluation of the clinical course and outcomes of the disease in adolescents.