1.
N Z Med J
; 98(792): 1036-8, 1985 Dec 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3867007
RESUMO
DNA mapping of the alpha globin gene cluster in cord blood from Polynesians has shown an increased frequency of alpha thalassaemia and triplicated alpha genes. Reduced levels of haemoglobin, mean corpuscular haemoglobin or mean corpuscular volume in these neonates may indicate alpha thalassaemia. Recognition of this will avoid unnecessary haematological investigations and iron supplementation.
Assuntos
Índices de Eritrócitos , Hemoglobinas/análise , Talassemia/sangue , Mapeamento Cromossômico , DNA/genética , Sangue Fetal/análise , Genótipo , Hemoglobinas Anormais/análise , Humanos , Recém-Nascido , Nova Zelândia , Linhagem , Polinésia/etnologia , Talassemia/genética
2.
Am J Hematol
; 18(4): 431-3, 1985 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2983539
RESUMO
Using gene mapping, 16.3% of Polynesians were shown to have alpha thalassemia. These results are surprising since malaria is not found in Polynesia. Moreover, triplicated alpha gene rearrangements were identified in a further 7.7%, a frequency not seen in other populations.