Perioperative and oncological outcomes of renal cell carcinoma with venous tumour thrombus.

AIM: The aim of the present study is to report the perioperative and long-term surgical outcomes of renal cell carcinoma (RCC) with venous tumour thrombus (VTT). MATERIALS AND METHODS: Data of 34 patients (males = 23, females = 11) from 2009 to 2020 who underwent radical nephrectomy with thrombectomy for RCC and VTT was retrospectively analysed. The parameters recorded include tumour laterality, size, level of thrombus, surgical approach, blood loss, transfusion rates, operative time, hospital stay, Clavien complications, tumour histology, follow-up duration, local recurrence, distant metastasis, overall and cancer-specific survival rates. RESULTS: The extent of thrombus was level I in thirteen, level II in twelve, level III (a-1, b-2, c-1, d-2) in six and level IV in three patients respectively. Mean operative time was 320 (±145) min, mean blood loss was 1371.15 (±1020.8) ml and mean hospital stay was 9.6 (±7.4) days. Mean transfusion rate was 6.4 (±3.2) units. Three patients died within the first 30 days of surgery. Cardiopulmonary bypass (CPB) was utilized in three patients. Median follow-up period was 58 (Range: 4-101) months. A statistically significant correlation was found between operative time (p = 0.014) and median survival (p = 0.003) respectively and tumour thrombosis level. Nine patients died due to metastasis, and ten due to unrelated causes. The estimated actuarial survival rates at a median of 58 months were 35.3%. CONCLUSION: An accurate preoperative assessment of the thrombus extent with the involvement of a multidisciplinary team approach is crucial in achieving optimal surgical outcomes in patients of RCC with VTT, particularly with level III and IV thrombus.

Hounsfield unit and its correlation with spontaneous expulsion of lower ureteric stone.

BACKGROUND: Hounsfield unit (HU) is the measure of stone density, and is utilized in the predetermination of type of stone. The purpose of this study was to identify some factors in noncontrast computed tomography (NCCT) of kidney, ureter, and bladder (KUB) that are easily extractable and can be used to determine the outcome of expectant management. METHODS: All patients 18-50 years of age who presented with flank pain and diagnosed as having lower ureteric calculi of size 5-10 mm by NCCT KUB were included in the study. HU of stone was calculated from the mean HU at three different regions of interest. We prescribed tamsulosin for 4 weeks as medical expulsive therapy. We divided the patients into two groups: group A included patients with successful expulsion of stone, and group B included patients who failed to pass stone. We compared age, gender, laterality, stone size in axial and coronal section of NCCT, HU of stone, blood urea, creatinine, and renal parenchymal thickness. RESULTS: A total of 180 patients with lower ureteric calculus were included in the study. The mean age of patients was 34 years, with male:female ratio of 2.3:1. Of these 180 patients, 119 (66%) successfully expelled the stone and were included in group A, with the remaining 61 (34%) forming group B. In univariate analysis, longitudinal diameter of stone (p < 0.001), transverse diameter of stone (p < 0.001) and high HU (p < 0.001) were significantly associated with failure of expulsion. However, in multivariate analysis only longitudinal diameter of stone (p < 0.001) differed significantly among groups. Differences in HU (p = 0.179) and transverse diameter of stone (p = 0.108) did not reach significance level. CONCLUSIONS: Lower ureteric calculi are definitely amenable to conservative management. Longitudinal diameter of stone can be a useful parameter; however, HU and its derivatives cannot be used as a predictor of outcome.

Emphysematous pyelonephritis: Does a standard management algorithm and a prognostic scoring model optimize patient outcomes?

OBJECTIVE: The objective of the study is to analyze the risk factors determining the outcomes of patients with emphysematous pyelonephritis (EPN) by the adoption of a standardized management algorithm as well as to develop a prognostic scoring model to risk stratify these patients. MATERIALS AND METHODS: The hospital records of 72 consecutive patients with EPN from February 2012 to January 2018 were retrospectively reviewed. Demographic, clinicoradiographic, and laboratory characteristics were recorded. Patients were managed with a standard management protocol and based on outcomes divided into three groups. Group I survived with conservative management, Group II survived after emergency nephrectomy, and Group III expired. The risk factors for nephrectomy and mortality were analyzed. RESULTS: The mean age was 53 years. Male to female ratio was 4:5. There were 61 (84.7%), 4 (5.6%), and 7 (10%) patients in Groups I, II, and III, respectively. Diabetes mellitus was the most common comorbidity detected in 62 (86%) of patients. Type II EPN was the most common radiological presentation observed in 32 (44%) patients. Overall survival rate was 90%, and kidney salvage rate was 80%. Escherichia coli was the most common organism isolated. Thirty-two (45%) patients exhibited resistance to third-generation cephalosporin antibiotics. Thrombocytopenia, low body mass index (BMI), presence of >2 comorbidities, high total leukocyte count (TLC), and hypoalbuminemia were significantly associated with mortality. On adoption of the prognostic scoring system, mortality rates according to the risk subgroups were as follows: favorable - 0%, intermediate - 19%, and poor - 100%. CONCLUSION: Conservative management adopting appropriate algorithm reduces mortality and avoids unnecessary emergency nephrectomies. Thrombocytopenia, low BMI, presence of >2 comorbidities, high TLC, and hypoalbuminemia were significantly associated with mortality.

Neonatal Intrathoracic Stomach without Gastric Volvulus.

Intrathoracic stomach is a rare and serious congenital abnormality. The anomaly may be complicated by gastric volvulus and can lead to ischemic gastric infarction in the neonate. If diagnosed antenatally, neonatal management can be planned in advance so as to reduce morbidity. This anomaly must be differentiated from the more common congenital diaphragmatic hernia, as associated pulmonary hypoplasia is common in the latter and rare with gastric herniation. We report a case of intrathoracic stomach in a neonate without volvulus, fortunately a rare entity which was managed operatively, and the child has been under regular follow-up.

Histopathological study of the outer membrane of the dura mater in chronic sub dural hematoma: Its clinical and radiological correlation.

BACKGROUND: A chronic subdural hematoma is an old clot of blood on the surface of the brain between dura and arachnoid membranes. These liquefied clots most often occur in patients aged 60 and older with brain atrophy. When the brain shrinks inside the skull over time, minor head trauma can cause tearing of blood vessels over the brain surface, resulting in a slow accumulation of blood over several days to weeks. AIM OF THE STUDY: To evaluate the role of membrane in hematoma evaluation and to correlate its histopathology with clinic-radiological aspects of the condition and overall prognosis of patients. MATERIAL AND METHODS: The study incorporated all cases of chronic SDH admitted to the Neurosurgery department of JLN Hospital and Research Centre, Bhilai, between November 2011 and November 2013. All such cases were analyzed clinically, radiologically like site, size, thickness in computed tomography, the attenuation value, midline shift and histopathological features were recorded. CRITERIA FOR INCLUSION: All cases of chronic subdural haematoma irrespective of age and sex were incorporated into the study. CRITERIA FOR EXCLUSION: All cases of acute subdural haematoma and cases of chronic sub dural hematoma which were managed conservatively irrespective of age and sex were excluded from the study. RESULTS: In our series of cases, the most common histopathological type of membrane was the inflammatory membrane (Type II) seen in 42.30% of cases followed by hemorrhagic inflammatory membrane (Type III) seen in 34.62% of cases while scar inflammatory type of membrane (Type IV) was seen in 23.08% of cases. No case with noninflammatory type (Type I) was encountered.

Esophageal lung: A rare type of communicating bronchopulmonary foregut malformation, case report with review of literature.

A 2-year-old female child was referred from a private hospital as a case of recurrent lower respiratory tract infections (LRTI). The chest X ray revealed a hypoplastic right lung and further workup led to the diagnosis of esophageal lung - a rare type of communicating bronchopulmonary foregut malformation. A right posterolateral thoracotomy was done, anamolous bronchial communication with esophagus disrupted, esophageal fistula repaired and the lung resected. Postoperatively, diet was allowed from day 7. The patient tolerated the diet well. Repeat dye study revealed no leak and subsequently the patient was discharged on day 10.