RESUMO
Objetivo. La espondilitis anquilosante (AS) es una enfermedad inflamatoria crónica con inflamación importante en las articulaciones y los órganos extraarticulares. Los pacientes con AS tienen aproximadamente dos veces más riesgo de mortalidad que la población normal. Una de las razones de este aumento en mortalidad, es el aumento del riesgo cardiovascular. Este estudio se planificó para evaluar la perfusión miocárdica y función ventricular izquierda con 99mTc-MIBI perfusión miocárdica sincronizada computarizada por emisión de foton único (SPECT). Material y métodos. El grupo de estudio consistió en 28 pacientes con AS (19 hombres y 9 mujeres), y la edad media de 39,46±10,98 años. Todos los pacientes fueron sometidos a 99mTc-MIBI SPECT de perfusión miocárdica sincronizada con el protocolo del mismo día. Resultados. Hemos detectado varios factores de riesgo como el hábito de fumar en 12, antecedentes familiares de enfermedad cardiovascular en 12, la hipertensión arterial en 3, la hiperlipidemia en 9 pacientes. Hemos llevado a cabo la perfusión miocárdica SPECT para cada paciente, el patrón de perfusión normal siendo en las imágenes SPECT. De los 28 pacientes, ocho pacientes tuvieron una perfusión normal, pero anomalías en el movimiento de la pared. Conclusión. Hemos detectado que la perfusión miocárdica se preserva en los pacientes con AS. Sin embargo, se observa anormalias en el movimiento de la pared venticular izquierda. Llegamos a la conclusión que la espondilitis anquilosante pueda ser asociados con la disfunción microvascular y la gammagrafía de perfusión miocárdica sincronizada podría ser útil en pacientes con EA para la evaluación de la función del ventrículo izquierdo, aún si existe una baja puntuación en el índice de actividad de la enfermedad espondilitis anquilosante (BASDAI) y menor duración de la enfermedad(AU)
Background. Ankylosing spondilitis (AS) is a chronic inflammatory disease with prominent inflammation in joints and extraarticular organs. AS patients have approximately two times more risk of mortality than the normal population. One reason for this increase in mortality is increased cardiovascular risk. In this study, we have aimed to evaluate myocardial perfusion and left ventricular function using 99mTc-MIBI gated myocardial perfusion single photon emission computed tomography (SPECT). Material and methods. The study group consisted of 28 AS patients (19 men, 9 women), and mean age 39.46±10.98 years. All patients underwent 99mTc-MIBI gated myocardial perfusion SPECT with the same day protocol. Results. We detected various risk factors including smoking habits in 12, family history of cardiovascular disease in 12, hypertension in 3, hyperlipidemia in 9 patients. We performed a myocardial perfusion SPECT for each patient and found normal perfusion pattern in SPECT images. Out of 28 patients, eight patients had normal perfusion but wall motion abnormalities. Conclusion. We detected that myocardial perfusion is preserved in the patients with AS. However, left ventricular wall motion abnormalities are seen. We concluded that ankylosing spondylitis may be associated with microvascular dysfunction and gated myocardial perfusion scintigraphy could be valuable in AS patients for the evaluation of LV function even if the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score are low and the disease duration shorter(AU)
Assuntos
Humanos , Masculino , Feminino , Espondilite Anquilosante/complicações , Espondilite Anquilosante , Tomografia Computadorizada por Emissão de Fóton Único de Sincronização Cardíaca/métodos , Tomografia Computadorizada por Emissão de Fóton Único de Sincronização Cardíaca , Imagem de Perfusão do Miocárdio/métodos , Função Ventricular/efeitos da radiação , /efeitos da radiação , /tendênciasRESUMO
BACKGROUND: Ankylosing spondilitis (AS) is a chronic inflammatory disease with prominent inflammation in joints and extraarticular organs. AS patients have approximately two times more risk of mortality than the normal population. One reason for this increase in mortality is increased cardiovascular risk. In this study, we have aimed to evaluate myocardial perfusion and left ventricular function using (99m)Tc-MIBI gated myocardial perfusion single photon emission computed tomography (SPECT). MATERIAL AND METHODS: The study group consisted of 28 AS patients (19 men, 9 women), and mean age 39.46±10.98 years. All patients underwent (99m)Tc-MIBI gated myocardial perfusion SPECT with the same day protocol. RESULTS: We detected various risk factors including smoking habits in 12, family history of cardiovascular disease in 12, hypertension in 3, hyperlipidemia in 9 patients. We performed a myocardial perfusion SPECT for each patient and found normal perfusion pattern in SPECT images. Out of 28 patients, eight patients had normal perfusion but wall motion abnormalities. CONCLUSION: We detected that myocardial perfusion is preserved in the patients with AS. However, left ventricular wall motion abnormalities are seen. We concluded that ankylosing spondylitis may be associated with microvascular dysfunction and gated myocardial perfusion scintigraphy could be valuable in AS patients for the evaluation of LV function even if the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score are low and the disease duration shorter.
