RESUMO
It was demonstrated experimentally that aminazine, phentolamine, nuredal, sapilent, teperin, dopegyt improved significantly the health status of animals exposed to high temperature and in many cases prevented their death. This gives evidence that the sympathetic nervous system plays a leading role in heat stroke and that sympathotrophic drugs can be used for protective purpose during acute overheating.
Assuntos
Modelos Animais de Doenças , Exaustão por Calor/tratamento farmacológico , Hipertermia Induzida/efeitos adversos , Estresse Fisiológico/tratamento farmacológico , Agonistas Adrenérgicos/administração & dosagem , Amobarbital/administração & dosagem , Animais , Quimioterapia Combinada , Feminino , Exaustão por Calor/etiologia , Masculino , Ratos , Estresse Fisiológico/etiologia , Tranquilizantes/administração & dosagemRESUMO
The article presents a set of newly elaborated specific techniques of the indication of protective pastes and ointments penetrability into the sealants. The techniques are based on the sealant's colour reactions to iron chloride spirits solution. It was established that skin protecting silicone creams, EIR-1 and HIOT pastes were sealant resistant for 4-6 minutes only. Medicinal vaseline displayed its protection properties for 6 hours, thus demonstrating its greater effectiveness when used in industrial conditions.
Assuntos
Dermatite Ocupacional/prevenção & controle , Irritantes/farmacologia , Vaselina/farmacologia , Pele/efeitos dos fármacos , Humanos , Pomadas , Vaselina/administração & dosagem , Silicones/administração & dosagem , Silicones/farmacologiaRESUMO
Development of heat stroke led to a decrease in main reactions of energy production and energy potential in erythrocytes, to a decrease in activity of Na+, K+-ATPase and in content of sodium and potassium as well as to alterations in forms and to decrease in volume of these cells.
Assuntos
Metabolismo Energético , Eritrócitos/metabolismo , Exaustão por Calor/metabolismo , Potássio/sangue , ATPase Trocadora de Sódio-Potássio/sangue , Sódio/sangue , Trifosfato de Adenosina/sangue , Animais , Eritrócitos/enzimologia , Eritrócitos/patologia , Feminino , Glicólise , Guanosina Difosfato/sangue , Exaustão por Calor/sangue , Exaustão por Calor/patologia , Masculino , RatosRESUMO
A body overheating was accompanied by alterations in erythrocyte resistancy to peroxidation, in activities of catalase, superoxide dismutase and glutathione reductase, which depended on the rate of overheating.