Cannabidiol on 5-FU-induced oral mucositis in mice.

PURPOSE: The aim of this study was to evaluate the clinical, histological, hematological, and oxidative stress effects of cannabidiol (CBD) in mice with induced oral mucositis. METHODS: We used 90 mice of the CF-1 strain in which oral mucositis was induced using a protocol with 5-fluorouracil (5-FU) chemotherapy. The animals were divided randomly into 10 study groups. Three groups were treated with different doses of CBD (3, 10, and 30 mg/kg), while 2 were control groups (positive control: 5-FU + mechanical trauma + placebo; and negative control: mechanical trauma + placebo), and 2 experimental times were studied (4 and 7 days). All treatments were by intraperitoneal administration. RESULTS: In the clinical evaluation, the groups treated with CBD showed less severity of oral lesions compared with the positive control at both experimental times. The intensity of the inflammatory response was also lower in the groups treated with this drug, but there was no statistically significant difference when compared with the positive control. With regard to erythrocyte, leukocyte, and platelet counts and anti-oxidant enzyme activity, the groups treated with CBD showed better results, but only some of these variables showed statistically significant differences. CONCLUSIONS: CBD seems to exert an anti-inflammatory and anti-oxidant activity favoring a faster resolution of oral mucositis in this animal model.

Doxycycline: An option in the treatment of ulcerated oral lesions?

WHAT IS KNOWN AND OBJECTIVES: In addition to its antimicrobial effect, doxycycline has potent anti-inflammatory activity. In view of these pharmacological characteristics, its use in the management of inflammatory, autoimmune and granulomatous diseases has been proposed. The objective of this study was to investigate, through a systematic literature review, the effect of doxycycline on pain and healing of ulcerated lesions of the mouth. METHODS: An electronic search was performed in accordance with PRISMA guidelines in PubMed, Cochrane Central Register, Web of Science, Bireme/LILACS and Scopus databases. Controlled, randomized clinical trials were selected. The concentration of doxycycline, frequency of application, pain relief and clinical remission of the lesions were analysed. RESULTS AND DISCUSSION: According to the inclusion criteria, five articles were selected. In four of these studies, doxycycline was used in the treatment of aphthous stomatitis, and in one study, it was used in the treatment of herpes labialis. In all studies, the drug was used topically, both as a hydrogel and as a crushed tablet (along with a prosthetic adhesive). The groups treated with doxycycline showed faster healing of lesions and lower pain scores compared to placebo. WHAT IS NEW AND CONCLUSION: The present study suggests that topical doxycycline has a positive effect on the treatment of recurrent aphthous ulceration and herpes labialis. Experimental animal studies and double-blind randomized clinical trials should be performed on other oral lesions, such as traumatic ulcers and mucositis.

Projection of the oblique line in periapical radiographs of mandibular molars / Projeção da linha oblíqua na região de molares inferiores em radiografias periapicais

Purpose: To identify and quantify the frequency of the projection of the oblique line over the alveolar crests of the mandibular molars in periapical radiographs. Methods: Five hundred periapical radiographs of the mandibular molar region were selected and evaluated for the presence or absence of the oblique line. When present, its interference on the image of the alveolar crest of the mandibular molars was analyzed. The data obtained was expressed as a percentage of the overlap of the oblique line to the alveolar crests of the mandibular molars. Results: The oblique line was observed in 363 out of the 500 periapical radiographs (72.6%). Out of the 363, 308 (84.8%) showed an overlap of the oblique line over the alveolar crests. However, 55 radiographs (15.1%) did not show such interference. Of the radiographs showing an overlap (308), the incidence of an overlap was 64.6% at a single site (199 radiographs), 33.4% at two sites (103 radiographs), and 1.9% (6 radiographs) at three sites. Conclusion: The overlap of the oblique line over the image of the alveolar crests in the mandibular molar region was observed in a significant portion of the total sample.

Objetivo: Identificar e quantificar a frequência da projeção da linha oblíqua sobre as cristas alveolares dos molares inferiores em radiografias periapicais. Metodologia: Foram selecionadas 500 radiografias periapicais da região de molares inferiores e avaliada a presença ou a ausência da linha oblíqua. Quando presente, foi analisada a interferência desta estrutura sobre a imagem das cristas alveolares dos molares inferiores. Os dados obtidos, considerando a frequência da sobreposição da linha oblíqua sobre as cristas alveolares dos molares inferiores foram expressos em percentagens. Resultados: Nas 500 radiografias periapicais avaliadas, a linha oblíqua foi observada em 363 radiografias (72,6%). Nestas, em 308 (84,8%), houve sobreposição da linha oblíqua sobre as cristas alveolares. Entretanto, em 55 radiografias (15,1%) não foi encontrada interferência. Nas radiografias em que houve a sobreposição da linha oblíqua sobre as cristas alveolares (308), a incidência de sobreposição em apenas um local foi de 64,6% (199 radiografias); em dois locais foi de 33,4% (103 radiografias) e em três locais foi de 1,9% (6 radiografias). Conclusão: A sobreposição da linha oblíqua sobre a imagem das cristas alveolares na região de molares inferiores representou uma fração significativa do total da amostra.