1.
J Am Chem Soc
; 137(12): 4038-41, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25636083
RESUMO
We report the synthesis and reactivity of a chiral aminoborane displaying both rapid and reversible H2 activation. The catalyst shows exceptional reactivity in asymmetric hydrogenation of enamines and unhindered imines with stereoselectivities of up to 99% ee. DFT analysis of the reaction mechanism pointed to the importance of both repulsive steric and stabilizing intermolecular non-covalent forces in the stereodetermining hydride transfer step of the catalytic cycle.