Health-related quality of life decline in clinically stable inflammatory bowel disease patients during the COVID-19 outbreak.

BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) affects many aspects of a patient's life and impairs their health-related quality of life (HRQoL). The COVID-19 outbreak has led to important mobility restrictions and a dramatic re-adjustment of social habits and health systems. This study aimed to assess the influence of the outbreak and mobility restrictions on the HRQoL of IBD patients with stable clinical remission on biologic treatment. Their self-perceived stress scores during the outbreak were also assessed. METHODS: A prospective, observational study was performed in IBD patients on biologic treatment with stable clinical remission. Patients with both Crohn's disease and Ulcerative Colitis patients were included. Patients filled in the IBDQ9 and the Perceived stress scale (PSS) electronically. To determine any changes, the results of the IBDQ9 during the outbreak were compared with the last IBDQ9 before the outbreak. RESULTS: 106 patients in clinical remission were included, with a median age of 42 year, 42% were female and 77% had CD. Median preCOVID-19 IBDQ9 was 72.1[66.5-80.12] and decreased to 69.2 [63.1-77.10] during the outbreak (p<0.001). The median PSS score was 12 [9-19]. There was a significant negative correlation between the PSS and the outbreak IBDQ9 (r=-0.66, p< 0.001). Regression analysis showed that the PSS score was associated with a lower IBDQ-9 during the outbreak(p<0.001) Conclusion: There was a negative impact of the COVID19 outbreak on the HRQoL of IBD patients in remission, with higher self-perceived stress scores associated with a lower QoL. The COVID-19 outbreak may have long-term implications for the HRQoL in these patients.

Health-related quality of life decline in clinically stable inflammatory bowel disease patients during the COVID-19 outbreak

Background and aims: Inflammatory bowel disease (IBD) affects many aspects of a patient’s life and impairs their health-related quality of life (HRQoL). The COVID-19 outbreak has led to important mobility restrictions and a dramatic re-adjustment of social habits and health systems. This study aimed to assess the influence of the outbreak and mobility restrictions on the HRQoL of IBD patients with stable clinical remission on biologic treatment. Their self-perceived stress scores during the outbreak were also assessed. Methods: A prospective, observational study was performed in IBD patients on biologic treatment with stable clinical remission. Patients with both Crohn’s disease and Ulcerative Colitis patients were included. Patients filled in the IBDQ9 and the Perceived stress scale (PSS) electronically. To determine any changes, the results of the IBDQ9 during the outbreak were compared with the last IBDQ9 before the outbreak. Results: 106 patients in clinical remission were included, with a median age of 42 year, 42% were female and 77% had CD. Median preCOVID-19 IBDQ9 was 72.1[66.5-80.12] and decreased to 69.2 [63.1-77.10] during the outbreak (p<0.001). The median PSS score was 12 [9-19]. There was a significant negative correlation between the PSS and the outbreak IBDQ9 (r=-0.66, p< 0.001). Regression analysis showed that the PSS score was associated with a lower IBDQ-9 during the outbreak(p<0.001) Conclusion: There was a negative impact of the COVID19 outbreak on the HRQoL of IBD patients in remission, with higher self-perceived stress scores associated with a lower QoL. The COVID-19 outbreak may have long-term implications for the HRQoL in these patients (AU)

Effectiveness of a Telephone-Based Motivational Intervention for Smoking Cessation in Patients With Crohn Disease: A Randomized, Open-Label, Controlled Clinical Trial.

A randomized, open-label, controlled clinical trial was designed to assess the effectiveness of a motivational intervention based on the 5 R's model (relevance, risks, rewards, roadblocks, and repetition) delivered by specialized inflammatory bowel disease nurses every 3 months over a 1-year period as compared with patients who were followed regularly. Patients diagnosed with Crohn disease, aged 18 years or older, who reported being active smokers with Internet access at home and an e-mail address were eligible. A total of 144 patients (72 per group) were included (50% women, median age 40 years). They smoked a median of 10 cigarettes per day (range = 1-40) and had been smoking for a median of 22 years (range = 1-51). Motivation to quit (Richmond test) was low in 73 patients, moderate in 39 patients, and high in 32 patients. Statistically significant differences between the study groups in the predisposition to change, motivation to quit, and tobacco withdrawal were not found. However, 14 patients (20.9%) in the intervention group and 9 patients (13.2%) among controls stopped smoking at the end of the study. These findings support a higher trend toward smoking cessation associated with the motivational intervention 5 R's. This behavioral strategy can aid patients with Crohn disease to quit smoking.

Perioperative management and early complications after intestinal resection with ileocolonic anastomosis in Crohn's disease: analysis from the PRACTICROHN study.

BACKGROUND: This study is aimed at describing the prevalence of and risk factors associated with early post-operative complications after Crohn's disease-related intestinal resection. METHODS: This was a retrospective analysis of data from the PRACTICROHN cohort. Adult Crohn's disease patients who underwent ileocolonic resection with ileocolonic anastomosis between January 2007 and December 2010 were included. The complications evaluated included death, ileus, anastomotic leak, abscess, wound infection, catheter-related infection, digestive bleeding and other extra-abdominal infections that occurred in the 30 days after surgery. RESULTS: A total of 364 patients (median age at surgery 38 years and 50% men) were included. Indication for surgery was: stricturing disease (46.4%), penetrating disease (31.3%), penetrating and stricturing disease (14.0%) or resistance to medical treatment (5.8%). Early complications were recorded in 100 (27.5%) patients, with wound infection, intra-abdominal abscess and anastomotic leakage being the most frequent complications. Median hospitalization duration was 16 days for patients with complications vs. 9 days without complications (P < 0.001). Complications were more common among patients with penetrating disease (36/114, 31.6%) and those refractory to treatment (9/21, 42.9%) compared with stricturing disease (45/169, 26.6%) or stricturing + penetrating disease (6/51, 11.8%) (P = 0.040). The rate of complications was higher among patients with diagnosis made at the time of surgery (15/31, 48.4%) compared with the rest (85/331, 25.7%) (P = 0.013). Medication received at the time of surgery did not affect the rate of complications. CONCLUSIONS: Almost a quarter of patients developed early complications after intestinal resection. Penetrating disease and urgent surgery were associated with an increased risk of complications.

Immunogenicity of hepatitis B vaccine in patients with inflammatory bowel disease and the benefits of revaccination.

BACKGROUND AND AIM: The vaccination against hepatitis B virus (HBV) is recommended in patients with inflammatory bowel disease (IBD). However, the response to this vaccine seems to be lower in IBD patients than in the general population. This study aims to evaluate the immunogenicity of the HBV vaccine in a cohort of patients with IBD, to associate factors with the response and to analyze the effects of a second schedule vaccination. METHODS: We conducted a retrospective cohort study of adults with IBD, susceptible to HBV infection. All patients received a three-dose standard schedule of HBV vaccine. Non-responders were revaccinated with a second three-dose standard schedule. Adequate immunity to HBV was defined as antibodies against hepatitis B surface antigen (anti-HBs) ≥ 10 mIU/mL. Age, comorbidities, treatment, and other variables were collected. RESULTS: One hundred seventy-two patients were included and received the first HBV vaccine schedule. Eighty-seven developed anti-HBs ≥ 10 mIU/mL (50.6%; 95% confidence interval [CI]: 42.9-58.3). From the non-responders, 53 were revaccinated and 28 showed an adequate serological response (52.8%; 95% CI: 38.6-66.7). Age older than 55 years (OR: 3.6; 95% CI: 1.3-10.2) and comorbidities (OR: 2.8; 95% CI: 1.1-7.1) were associated with suboptimal response. In the multivariate analysis, only age was a predictor of non-response (age higher than 55 years; OR: 3.9; 95% CI: 1.3-11.9) CONCLUSION: The response rate to the HBV vaccine is lower in patients with IBD compared with the general population, especially in those older than 55 years. Revaccination improved response rate by 50%.

Effect upon hospital activity of the application of a continued care model centered on patients with inflammatory bowel disease.

BACKGROUND: Since 1999, the Crohn-Colitis Care Unit (UACC) has been dedicated to the integral management of patients with Crohn´s disease (CD) and ulcerative colitis (UC). The working methodology of the UACC is based on personalized, continued, nonphysical presence, open access and patient-centered care. From its creation, the UACC has experienced an increase in the number of its users and outpatient services. However, the impact of the activity of the UACC upon patient hospitalization is not known. OBJECTIVES: To determine the hospital activity related to CD and UC, and correlate it to the activity of the UACC. METHODS: A retrospective evaluation was made of the physical presence and non-presence activities of the UACC from January 1999 to December 2008, and of the hospital admissions and mean durations of stay due to CD and UC during that same time period. RESULTS: The number of attended patients and of presence and non-presence activities of the UACC has gradually increased. This increase contrasts with the number of annual hospital admissions, which has remained stable during the study period, with 200-300 admissions/year. Consequently, the hospitalized patients / UACC registered patients ratio has decreased from 0.36 at the start of the study period to 0.14 at the end. The median hospital stay has also decreased, from 11 days at the start of the study period to 8 days at the end. CONCLUSIONS: The UACC allows effective management of IBD patient care, since it is able to attend the needs of more patients without increasing the number of admissions, and shortening the duration of hospital stay.

Efecto de la aplicación de un modelo de asistencia continuada centrada en el paciente con enfermedad inflamatoria intestinal en la actividad hospitalaria / Effect upon hospital activity of the application of a continued care model centered on patients with inflammatory bowel disease

Introducción: desde 1999 está en funcionamiento la Unidad de Atención Crohn-Colitis (UACC) para la atención integral a los pacientes con enfermedad de Crohn (EC) y colitis ulcerosa (CU). La UACC sigue un método de trabajo basado en la atención personalizada, continuada, no presencial, de acceso abierto y centrada en el paciente. Desde su implantación, la UACC se ha relacionado con un aumento en el número de usuarios y de actividades. Se desconoce, sin embargo, la repercusión que tiene el funcionamiento UACC sobre la hospitalización de los pacientes. Objetivos: determinar la actividad hospitalaria relacionada con la EC y la CU y su relación con la actividad desarrollada en la UACC. Métodos: revisión de la actividad desarrollada en la UACC desde enero de 1999 a diciembre de 2008, y de los ingresos hospitalarios y estancias medias hospitalarias por EC y CU en el mismo período. Resultados: el número de usuarios y de actividades prestadas en la UACC, ha aumentado de forma progresiva. Dicho incremento contrasta con el número anual de ingresos hospitalarios, que ha permanecido estacionario en 200-300 ingresos/año. En consecuencia, la ratio pacientes hospitalizados/pacientes registrados en la UACC ha disminuido de 0,36 a 0,14. La estancia media hospitalaria también se ha reducido, de 11 días a 8 días al final del periodo de observación. Conclusiones: el modelo UACC permite una gestión más eficaz de atención a los pacientes con EII ya que consigue atender las necesidades de más pacientes, sin aumentar el número de ingresos y acortando las estancias hospitalarias(AU)

Background: since 1999, the Crohn-Colitis Care Unit (UACC) has been dedicated to the integral management of patients with Crohn’s disease (CD) and ulcerative colitis (UC). The working methodology of the UACC is based on personalized, continued, nonphysical presence, open access and patient-centered care. From its creation, the UACC has experienced an increase in the number of its users and outpatient services. However, the impact of the activity of the UACC upon patient hospitalization is not known. Objectives: to determine the hospital activity related to CD and UC, and correlate it to the activity of the UACC. Methods: a retrospective evaluation was made of the physical presence and non-presence activities of the UACC from January 1999 to December 2008, and of the hospital admissions and mean durations of stay due to CD and UC during that same time period. Results: the number of attended patients and of presence and non-presence activities of the UACC has gradually increased. This increase contrasts with the number of annual hospital admissions, which has remained stable during the study period, with 200-300 admissions/year. Consequently, the hospitalized patients / UACC registered patients ratio has decreased from 0.36 at the start of the study period to 0.14 at the end. The median hospital stay has also decreased, from 11 days at the start of the study period to 8 days at the end. Conclusions: the UACC allows effective management of IBD patient care, since it is able to attend the needs of more patients without increasing the number of admissions, and shortening the duration of hospital stay(AU)

[Application of a model of continued attention in inflammatory bowel disease: the Crohn-colitis care unit]. / Aplicación de un modelo de asistencia continuada en la enfermedad inflamatoria intestinal: la Unidad de Atención Crohn-Colitis.

OBJECTIVE: To describe the activity performed in the Crohn-Colitis Care Unit (CCCU) and its web portal (http://www.ua-cc.org) during the first 9 years (1999-2007). MATERIAL AND METHODS: We retrospectively reviewed the presential and non-presential activity carried out in the CCCU from January 1999 to June 2007 by analyzing the data available in the data base and in the CCCU web portal from January 2002 (data available from the private web environment). RESULTS: The number of patients has progressively increased, and currently stands at 1784. There is equal distribution by gender (880 men vs 904 women) and diagnosis (849 Crohn's disease vs 893 ulcerative colitis). Patients are mostly younger than 50 years old (1404 patients). The non-presential resources (telephone and fax) have been used to a greater extent than the presential resources (11,173 vs 5164). Most requests (15,198) have been specific consultations relating to the disease. The CCCU also monitors treatments such as corticosteroids, immunomodulators, biological agents and granulocyte apheresis (663 in the last year). The web portal has received more than 150,000 visits and has 3698 registered users (1552 patients, 1374 health professionals, 384 relatives of patients, and 388 institutions), mostly from Spain and Latin America (2087 and 1555 respectively). CONCLUSIONS: The CCCU offers continued, participative and dynamic care, which promotes remote healthcare and optimizes the care of patients with inflammatory bowel disease.

Aplicación de un modelo de asistencia continuada en la enfermedad inflamatoria intestinal: la Unidad de Atención Crohn-Colitis / Application of a model of continued attention in inflammatory bowel disease: the Crohn-colitis care unit

Objetivos: describir la actividad desarrollada en la Unidad de Atención Crohn-Colitis (UACC) en sus 9 años de funcionamiento y su línea virtual (http://www.ua-cc.org).Material y métodos: revisión retrospectiva de la actividad presencial y a distancia desempeñada en la UACC desde enero de 1999 a junio de 2007 (mediante el análisis de los datos disponibles en la base de datos), y del portal web de la UACC desde enero de 2002 (datos disponibles en el entorno web de uso privado).Resultados: el número de pacientes ha ido aumentando de forma progresiva, y actualmente es de 1.784. Hay una distribución igual por género (880 varones y 904 mujeres) y diagnóstico (849 con enfermedad de Crohn y 893 con colitis ulcerosa). La población atendida esencialmente es menor de 50 años (1.404 pacientes). La atención a distancia (telefónica y fax) ha sido la prioritaria, se han atendido 11.173 demandas y de forma presencial 5.164. La mayoría de las demandas (15.198) han sido consultas específicas sobre la enfermedad. Desde la UACC, también se registran los tratamientos corticoideos, inmunomoduladores, agentes biológicos y granulocitoaféresis (663 en el último año). El portal web ha recibido más de 150.000 visitas y cuenta con 3.698 usuarios registrados (1.552 pacientes, 1.374 profesionales de la salud, 384 familiares de pacientes y 388 de otras instituciones), la mayoría españoles y de países sudamericanos (2.087 y 1.555, respectivamente).Conclusiones: la UACC presta una atención continuada, participativa y dinámica, que promociona el control a distancia y optimiza la atención sanitaria de los pacientes con enfermedad inflamatoria intestinal(AU)

Objective: To describe the activity performed in the Crohn-Colitis Care Unit (CCCU) and its web portal (http://www.ua-cc.org) during the first 9 years (1999–2007).Material and methods: We retrospectively reviewed the presential and non-presential activity carried out in the CCCU from January 1999 to June 2007 by analyzing the data available in the data base and in the CCCU web portal from January 2002 (data available from the private web environment).Results: The number of patients has progressively increased, and currently stands at 1784. There is equal distribution by gender (880 men vs 904 women) and diagnosis (849 Crohn's disease vs 893 ulcerative colitis). Patients are mostly younger than 50 years old (1404 patients). The non-presential resources (telephone and fax) have been used to a greater extent than the presential resources (11,173 vs 5164). Most requests (15,198) have been specific consultations relating to the disease. The CCCU also monitors treatments such as corticosteroids, immunomodulators, biological agents and granulocyte apheresis (663 in the last year). The web portal has received more than 150,000 visits and has 3698 registered users (1552 patients, 1374 health professionals, 384 relatives of patients, and 388 institutions), mostly from Spain and Latin America (2087 and 1555 respectively).Conclusions: The CCCU offers continued, participative and dynamic care, which promotes remote healthcare and optimizes the care of patients with inflammatory bowel disease(AU)