RESUMO
Bronchial reactivity after Cimetidine treatment was evaluated by the histamine provocation test in 24 patients with atopic bronchial asthma and 10 patients with peptic ulcer. Anti-IgE induced histamine release from isolated basophils was also investigated. After blockade of H2 receptors, an increase of bronchial reactivity and an exacerbation of clinical symptoms were observed in 4 asthmatic patients [17%]. A moderate increase in bronchial reactivity without exacerbation of asthma symptoms was observed in 16 other patients [66%]. In some of the patients treated with Cimetidine an enhancement of IgE-induced histamine release from isolated basophils was observed.
Assuntos
Asma/fisiopatologia , Brônquios/efeitos dos fármacos , Antagonistas dos Receptores H2 da Histamina/farmacologia , Brônquios/fisiopatologia , Testes de Provocação Brônquica , Cimetidina/farmacologia , Histamina/farmacologia , Liberação de Histamina/efeitos dos fármacos , Humanos , Úlcera Péptica/fisiopatologiaAssuntos
Eletrocirurgia/métodos , Prostatectomia/métodos , Hiperplasia Prostática/cirurgia , Idoso , Eletrocirurgia/efeitos adversos , Seguimentos , Hospitais de Ensino , Humanos , Masculino , Pessoa de Meia-Idade , Polônia , Complicações Pós-Operatórias/etiologia , Prostatectomia/efeitos adversos , Unidade Hospitalar de UrologiaRESUMO
Spontaneous arginine esterase activity and esterolytic activity of plasma after a contact with kaolin, using a synthetic substrate BAEE in asthmatic patients were studied. Also activity of esterase inhibitors, the plasma kininogen level and fibrinolytic activity were determined. It was shown, that during an asthma attack a significant rise in the plasma esterolytic activity occurred. At the same time esterase activity displayed a fall after contact with kaolin as compared with controls. These changes were accompanied by a rise in the fibrinolytic activity of the plasma and a decrease in the kininogen level. The behavior of parameters studies was analyzed in relation to the immunological type of asthma and the clinical state of the patients.
Assuntos
Asma/enzimologia , Hidrolases de Éster Carboxílico/sangue , Asma/sangue , Asma/fisiopatologia , Hidrolases de Éster Carboxílico/antagonistas & inibidores , Fibrinólise , HumanosRESUMO
The effect of hydrocortisone and disodium cromoglycate (Intal) on histamine release during immediate allergic reaction in experimental animals was studied. Histamine level in the blood and lung tissue was determined before antigen challenge during experimental asthma and after administration of hydrocortisone or Intal. The investigations revealed some differences in the histamine content in the blood and lung tissue depending on the time of the drug administration in relation to the antigen challenge and to the period of treatment.
Assuntos
Anafilaxia/metabolismo , Asma/metabolismo , Cromolina Sódica/uso terapêutico , Histamina/metabolismo , Hidrocortisona/uso terapêutico , Pulmão/metabolismo , Anafilaxia/tratamento farmacológico , Animais , Asma/tratamento farmacológico , Cobaias , Histamina/sangue , Liberação de Histamina/efeitos dos fármacosRESUMO
The experiments were carried out on immunized guinea-pigs. Histamine concentration in the blood and the lung tissue, the plasma prekallikrein and kininogen levels, kininase and fibrinolytic activity were determined. The examinations were made before antigen challenge, during anaphylactic reaction and after pharmacological inhibition of proteolysis. As protease inhibitors--Trasylol and EACA were used. The inhibition of the kinin and fibrinolytic systems by Trasylol and EACA did not markedly affect the allergic symptoms and did not change the high level of blood and lung tissue histamine. These experiments suggest that activation of the kinin system is not essential for the initiation of the immediate response but is the consequence of immunological release of histamine and other mediators.
Assuntos
Anafilaxia/metabolismo , Fibrinólise , Liberação de Histamina , Cininas/biossíntese , Animais , Asma/metabolismo , Cobaias , Liberação de Histamina/efeitos dos fármacos , Técnicas In Vitro , Calicreínas/metabolismo , Cininogênios/metabolismo , Pulmão/metabolismo , Ovalbumina/imunologiaAssuntos
Basófilos/metabolismo , Liberação de Histamina/efeitos dos fármacos , Hidrocortisona/uso terapêutico , Mastócitos/metabolismo , Adulto , Animais , Anticorpos Anti-Idiotípicos , Asma/tratamento farmacológico , Células Cultivadas , Glucocorticoides/uso terapêutico , Cobaias , Antagonistas dos Receptores Histamínicos , Cavalos , Humanos , Soros Imunes/farmacologia , Imunoglobulina E , Intestinos , Pessoa de Meia-Idade , Peritônio , Ratos , Ratos Endogâmicos , p-Metoxi-N-metilfenetilamina/farmacologiaRESUMO
The blood histamine level was determined in 66 patients with bronchial asthma and 25 guinea-pigs in whom the asthma attacks were induced by histamine or ovoalbumin inhalation after previous immunization of the animals. At the same time, histamine content of the lung tissue of the guinea-pigs was determined. It was found that in both humans and animals the level of blood histamine during immediate allergic reactions rises significantly. The extent of this rise depends on intensity of the reaction and time of determination. In asymptomatic period the blood histamine level did not differ from that of the control groups. Histamine concentration in the lung tissue of many of the animals increased during asthma attack but not in all cases was this increase correlated to the rise in blood histamine level. The reasons for these changes are discussed.