[Urinary bladder xanthoma. A cystoscopic finding]. / Xantoma vesical. Hallazgo cistoscopico.

Urinary bladder xanthoma (UBX) is an infrequent lesion that has been very rarely referred to in medical literature. We describe a case of UBX that was associated with a low-grade transitional cell carcinoma of the urinary bladder. The cystoscopic aspect of this lesion was so characteristic that diagnosis could be suggested at cystoscopy, while histological examination confirmed this.

Xantoma vesical. Hallazgo cistoscopico / Urinary bladder xanthoma. A cystoscopic finding

Se presenta un caso de xantoma vesical, asociado a carcinoma de células transicionales de vejiga, como hallazgo casual en la cistoscopia practicada para estudio de una hematuria macroscópica. El hallazgo de xantomas en la vejiga es muy raro. Se han descrito 9 casos en la literatura. Sus manifestaciones clínicas son inespecíficas. Se suele objetivar como un hallazgo cistoscópico con imagen característica que hay que diferenciar histológicamente de otras lesiones vesicales de aspecto semejante

Urinary bladder xanthoma (UBX) is an infrequent lesion that has been very rarely referred to in medical literature. We describe a case of UBX that was associated with a low–grade transitional cell carcinoma of the urinary bladder. The cystoscopic aspect of this lesion was so characteristic that diagnosis could be suggested at cystoscopy, while histological examination confirmed this

[Vegetable foreign body in the testis]. / Cuerpo extraño vegetal intratesticular.

A vegetable foreign body located inside the testicular parenchyma is presented. It's about an unexpected pathological finding in an orchidectomy sample, performed on account of testicular atrophy secondary to very advanced funicular twist. The finding of a vegetal material inside the testis is outstanding. In our knowledge we don't know about another similar case. Pathologic aspects, including granulomatous reaction, regarding arguments of testicular atrophy and the foreign body eruption mechanism are discussed. The handling of the scrotum by paramedical people could justify his presence.

Cuerpo extraño vegetal intratesticular / Vegetable foreign body in the testis

Se presenta un caso de cuerpo extraño de origen vegetal ubicado en el parénquima testicular. Se trata de un hallazgo anatomopatológico inesperado en una pieza de orquiectomía realizada con motivo de la atrofia testicular secundaria a una torsión de cordón muy evolucionada. El hallazgo de un material vegetal dentro del testículo es excepcional y, en nuestro conocimiento, no existen otras comunicaciones al respecto. Se discuten los aspectos anatomopatológicos, incluida la reacción granulomatosa presente, así como las cuestiones relacionadas con la atrofia testicular y el mecanismo de entrada del cuerpo extraño. La manipulación del escroto por parte de curanderos durante la fase de atrofia testicular explica la presencia de este material vegetal intratesticular (AU)

CD20-negative DLBCL transformation after rituximab treatment in follicular lymphoma: a new case report and review of the literature.

Rituximab is a monoclonal antibody against the CD20 molecule which is used to treat B-cell lymphomas. In 60% of low-grade B lymphomas in which rituximab was effective at first, there was no clinical response in a second treatment and a few cases of follicular lymphomas (FL) with transformation to diffuse large B-cell lymphoma (DLBCL) have been reported. We describe a new case and hypothesize about the mechanisms of transformation: a 52-year-old man, in follow-up during 8 years for FL, who after rituximab treatment and complete remission of FL showed progressive disease involving the liver and duodenal mucosa. Immunohistochemical and molecular studies were performed on paraffin-embedded tissue samples of lymph nodes, the small intestine, and liver tumors. After rituximab treatment, biopsies of a liver lesion and the small bowel both showed CD20-negative large B-cell lymphoma. Molecular study of the initial and relapse specimens shows a CDR2 IgH rearrangement with the same height and t14;18 (MBR). The rapid relapse with the same rearrangement of IgH seems to support the interpretation that the change of grade of lymphoma and loss of CD20 expression occurred before rituximab treatment. The existence of a varying proportion of a CD20-negative cell population in every B-cell lymphoma which does not respond to rituximab should therefore be considered. The reduction of CD20 expression could be a resistance mechanism to rituximab retreatment in DLBCL as a consequence of the progression of low-grade B-cell non-Hodgkin's lymphoma (B-NHL). It is necessary to perform new biopsies to evaluate CD20 expression in relapse or the progression of B-cell lymphoma after rituximab treatment.

[Melanoma metastatic to the female urethra. Report of a case]. / Melanoma metastásico a uretra femenina. Aportación de un caso.

We report a case of a 77 years old woman with an previous malignant melanoma, who presented an urethral metastasis. The disease was treated with conservative therapy by local excision after pedicle ligation, and she is free of symptoms after one 1 year of control.

Melanoma metastásico a uretra femenina. Aportación de un caso / Primary melanoma metastatized to female urethra. Contribution of one case

Se describe el caso de una mujer de 77 años con el antecedente previo de melanoma maligno en extremidad inferior, que presentó una lesión uretral compatible con metástasis de melanoma maligno. La lesión fue tratada con medidas conservadoras por medio de una exéresis local tras ligadura de su pedículo, estando la paciente asintomática a 1 año de seguimiento (AU)

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Técnicas de desenmascaramiento antigénico e inmunohistoquímica. Estudio dirigido a anticuerpos con especiales dificultades de inmunodetección / Antigenic unmasking techniques in immunohistochemistry

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Ultrasonography and CT findings of a dermoid cyst of the cecum. A case report.

We report the US and CT findings of a dermoid cyst of the cecum, which is a very uncommon location for this entity. Pathological correlation and differential diagnosis are briefly discussed.

Fine needle aspiration and touch imprint cytology of a malignant fibrous histiocytoma of the spermatic cord. Case report.

BACKGROUND: No cytologic reports on spermatic cord sarcomas have been published. CASE: A 64-year-old man presented with a slowly growing, painless, left spermatic cord enlargement. Fine needle aspiration (FNA) obtained < 1 mL of bloody fluid consisting of solitary, mark-edly anaplastic and pleomorphic tumor giant cells occasionally arranged in small fragments. Rare atypical spindle cells could be observed. Some reactive lymphocytes were observed intermingled with tumor cells. Immunohistochemistry displayed vimentin reactivity and negativity for keratins and leukocytic common antigen. The specimen removed showed a well-circumscribed, 30-mm, yellowish solid tumor. Touch imprints displayed pleomorphic tumor cells showing intense anisonucleosis; a moderate amount of clear, sometimes microvacuolated cytoplasm; and tissue fragments with a storiform pattern. Histologic examination revealed microscopic and immunohistochemical features of malignant fibrous histiocytoma (MFH) arising in soft tissues of the spermatic cord. CONCLUSION: FNA of a spermatic cord lesion may reveal a pleomorphic sarcoma. A pleomorphic appearance together with some spindle elements and compatible immunocytochemistry could help diagnose spermatic cord MFH. This is one of the few reports dealing with FNA cytology of paratesticular tumors and the first report, to the best of our knowledge, showing the cytologic characteristics of a case of spermatic cord MFH.

[Hodgkin's disease. Etiopathogenic role of Epstein-Barr virus in Tarragona]. / Enfermedad de Hodgkin. Papel etiopatogénico del virus de Epstein-Barr en las comarcas de Tarragona.

BACKGROUND: The aim of this study is to assess the proportion of Hodgkin disease (HD) expressing Epstein-Barr virus (EBV) in our area (Tarragona-Spain). PATIENTS AND METHODS: A retrospective study was performed on paraffin embedded HD tissues from 49 patients to examine the presence of latent membrane protein (LMP-1) by immunohistochemistry and for EBER-1 in situ hybridization. RESULTS: Overall, EBV (EBER-1 and/or LMP positive) was expressed in 20 cases (40.8%). This percentage was higher, but not significant, in mixed cellularity, and significant higher in patients over 55 years old. No differences between sexes were observed. CONCLUSIONS: EBV is associated with 40.8% of HD in area of Tarragona.

Fine needle aspiration cytology of a cervical lymph node lymphangioma in an adult. A case report.

BACKGROUND: Although the cytologic features of cervical cystic lesions are well established, no cytology reports on lymphangioma in adults have been published. CASE: A 60-year-old male presented with a slowly growing, upper laterocervical, painless enlargement. Fine needle aspiration (FNA) obtained 15 mL of yellowish fluid, consisting predominantly of a uniform population of small and round lymphocytes without mitosis or atypia and with some histiocytes intermingled with them. Some centrocytes and occasionally centroblasts and plasma cells could also be observed. Immunohistochemistry performed on cell block sections displayed polyclonal B lymphocytes mixed with T cells. The specimen showed a clearly circumscribed, 50-mm, cystic lesion with a multilocular appearance and abundant, yellowish liquid. Microscopic examination demonstrated cystic lymphangioma arising from the medullary portion of a lymph node. CONCLUSION: FNA cytology permits a suggested diagnosis of lymphangioma. This is one of the few reports of FNA cytology of lymphangioma and, to the best of our knowledge, this entity has not previously been found as a neck mass in an adult.

[Primary signet ring cell adenocarcinoma of the bladder. Report of 2 cases of bladder plastic linitis]. / Adenocarcinoma de células en anillo de sello primario de vejiga. Presentación de dos casos de linitis plástica vesical.

OBJECTIVES: Two additional cases of signet-ring cell adenocarcinoma of the urinary bladder, an uncommon highly malignant tumor type, are described. METHODS/RESULTS: The clinical features, histopathological findings and immunohistochemical study are presented. CONCLUSIONS: Both cases previously had cystic glandular cystitis, which supports the totipotent urothelium origin of this neoplasm. Signet-ring cell adenocarcinoma or linitis plastica of the bladder has a highly malignant course despite neoadjuvant chemotherapy and total cystectomy.