RESUMO
Heavy metal pollution of aquatic ecosystems is worldwide problem with consequences on the aquatic organisms. The concentrations of selected heavy metals (Fe, Mn, Zn, Cu, Cd and Pb) were determined in liver, kidney, gills, muscle and bone of barbel (Barbus rebeli) and chub (Squalius squalius) from the river Crn Drim in Macedonia. In general, liver and kidney in both fish species contained the highest concentration of the investigated metals, while muscle showed lowest bioaccumulation of heavy metals. Analyses supported significant seasonal differences in some organs for some metals: highest value in spring-summer compared to autumn-winter period. Generally, metal concentration was higher in the barbel than chub. The concentration of metals in muscle are bellow permissible value and do not constitute any threat for human health due to the consumption of metal loaded fish.