Prescription for Love: An Experimental Investigation of Laypeople's Relative Moral Disapproval of Love Drugs.

New technologies regularly bring about profound changes in our daily lives. Romantic relationships are no exception to these transformations. Some philosophers expect the emergence in the near future of love drugs: a theoretically achievable biotechnological intervention that could be designed to strengthen and maintain love in romantic relationships. We investigated laypeople's resistance to the use of such technologies and its sources. Across two studies (Study 1, French and Peruvian university students, N after exclusion = 186; Study 2, Amazon Mechanical Turk sample, N after exclusion = 693, pre-registered), we found that the use of love drugs designed to strengthen and maintain love in romantic relationships are considered as more morally problematic than psychological therapy with the same aim. In Study 2, we show that this last effect is partially due to the fact that the love resulting from the use of love drugs is perceived as less authentic, intense, and durable. We discuss the specific role of authenticity in the relative moral disapproval of love drugs.

A validation and comparison of three measures of participants' disposition to feel moved (introducing the Geneva Sentimentality Scale).

In the past years, psychologists have been increasingly interested in feelings of "being moved" (or "touched") and their impact on cognition and behaviour. However, to better understand their long-term impact, we need a validated measure of participants' disposition to feel "moved". In this paper, we introduce the Geneva Sentimentality Scale (GSS), a measure of participants' disposition to feel moved. After describing its construction (Study 1) and confirming its structure and internal coherence (Study 2), we compare it to two other measures of participants' disposition to feel moved: the Kama Muta Frequency scale (KAMF) and a single-item measure ("I often feel moved"). We show that all three measures reliably predict participants' response to moving stimuli (Study 2) and their feelings of being moved in the past week (Study 3) and next week (Study 5). Moreover, we show that the GSS and KAMF have good test-retest reliability (Studies 4 & 5). Overall, we conclude that all three measures provide experimenters with useful tools to investigate the role feelings of being moved play in our lives.

Association of Serum Pyridoxal Phosphate Levels with Established Status Epilepticus.

BACKGROUND: The objective of this study was to determine the prevalence of pyridoxine deficiency, measured by pyridoxal phosphate (PLP) levels, in patients admitted to the hospital with established (benzodiazepine-resistant) status epilepticus (SE) (eSE) and to compare to three control groups: intensive care unit (ICU) patients without SE (ICU-noSE), non-ICU inpatients without SE (non-ICU), and outpatients with or without a history of epilepsy (outpatient). METHODS: This retrospective cohort study was conducted at the University of North Carolina Hospitals and Yale New Haven Hospital. Participants included inpatients and outpatients who had serum PLP levels measured during clinical care between January 2018 and March 2021. The first PLP level obtained was categorized as normal (> 30 nmol/L), marginal (≤ 30 nmol/L), deficient (≤ 20 nmol/L), and severely deficient (≤ 5 nmol/L). RESULTS: A total of 293 patients were included (52 eSE, 40 ICU-noSE, 44 non-ICU, and 157 outpatient). The median age was 55 (range 19-99) years. The median PLP level of the eSE group (12 nmol/L) was lower than that of the ICU-noSE (22 nmol/L, p = 0.003), non-ICU (16 nmol/L, p = 0.05), and outpatient groups (36 nmol/L, p < 0.001). Patients with eSE had a significantly higher prevalence of marginal and deficient PLP levels (90 and 80%, respectively) than patients in each of the other three groups (ICU-noSE: 70, 50%; non-ICU: 63, 54%; outpatient: 38, 21%). This significantly higher prevalence persisted after correcting for critical illness severity and timing of PLP level collection. CONCLUSIONS: Our study confirms previous findings indicating a high prevalence of pyridoxine deficiency (as measured by serum PLP levels) in patients with eSE, including when using a more restricted definition of pyridoxine deficiency. Prevalence is higher in patients with eSE than in patients in all three control groups (ICU-noSE, non-ICU, and outpatient). Considering the role of pyridoxine, thus PLP, in the synthesis of γ-aminobutyric acid and its easy and safe administration, prospective studies on pyridoxine supplementation in patients with eSE are needed.

High Stress Levels and Trust toward the Government Are Associated with More Positive Attitudes toward COVID-19 Vaccines among French Students: A Pilot Study.

Mistrust in COVID-19 vaccines may hinder vaccination campaigns. We looked at cognitive determinants of vaccination intentions against COVID-19. We were interested in (i) the effects of stress and (ii) the effects of self-protection systems on attitudes and intentions to get COVID-19 vaccines. We conducted an online observational pilot study with 203 participants and used self-report questionnaires to assess perceived stress and vulnerability to disease, beliefs about a dangerous world, pandemic-related stressors, living conditions, attitudes and intentions toward the vaccines and trust in government management of the COVID-19 pandemic. The participants reporting high levels of trust in government and high levels of stress were more likely to have positive attitudes toward COVID-19 vaccines, although these two effects are at least partially independent of each other. We discuss how to improve the communication around COVID-19 vaccine policies.

Situational factors shape moral judgements in the trolley dilemma in Eastern, Southern and Western countries in a culturally diverse sample.

The study of moral judgements often centres on moral dilemmas in which options consistent with deontological perspectives (that is, emphasizing rules, individual rights and duties) are in conflict with options consistent with utilitarian judgements (that is, following the greater good based on consequences). Greene et al. (2009) showed that psychological and situational factors (for example, the intent of the agent or the presence of physical contact between the agent and the victim) can play an important role in moral dilemma judgements (for example, the trolley problem). Our knowledge is limited concerning both the universality of these effects outside the United States and the impact of culture on the situational and psychological factors affecting moral judgements. Thus, we empirically tested the universality of the effects of intent and personal force on moral dilemma judgements by replicating the experiments of Greene et al. in 45 countries from all inhabited continents. We found that personal force and its interaction with intention exert influence on moral judgements in the US and Western cultural clusters, replicating and expanding the original findings. Moreover, the personal force effect was present in all cultural clusters, suggesting it is culturally universal. The evidence for the cultural universality of the interaction effect was inconclusive in the Eastern and Southern cultural clusters (depending on exclusion criteria). We found no strong association between collectivism/individualism and moral dilemma judgements.

Venezuelan Forced Migration to Peru During Sociopolitical Crisis: an Analysis of Perceived Social Support and Emotion Regulation Strategies.

While many studies have examined the impact of forced migration on Venezuelan migrants in Latin America, to date scholars have not examined the effect of certain coping mechanisms, namely social support and emotion regulation. Using data from 386 Venezuelan migrants living in Peru (M = 20.22 years, SD = 1.33, 46.4% women), we investigated whether perceived social support from three different sources (family, friends, and significant other) correlated with emotion regulation strategies (cognitive reappraisal and suppression) while controlling for the type of cohabitation and time of residence. The results (1) confirmed the originally proposed internal structure of the Multidimensional Perceived Social Support Scale and Emotion Regulation Questionnaire, showing reliability and validity even in a sample of migrants. Findings demonstrated that (2) perceived social support from family positively predicted cognitive reappraisal strategy when including friends and significant other as covariates; (3) Venezuelans who have resided longer in Peru compared to more recent migrants used cognitive reappraisal strategy at a higher rate despite perceiving low family social support; (4) Venezuelans who resided in Peru for a longer period of time reported higher suppression strategy use when having low significant other support; and (5) there were gender differences regarding cognitive reappraisal as a dependent variable. More specifically, in men, family was a better predictor than friend or significant other support, while among women, family and significant other had the biggest impact. These results demonstrate the importance of social support elements and time of residence on the healthy management of emotions under difficult circumstances, such as forced migration.

Keeping Meta-Analyses Hygienic During the COVID-19 Pandemic.

Despite the massive distribution of different vaccines globally, the current pandemic has revealed the crucial need for an efficient treatment against COVID-19. Meta-analyses have historically been extremely useful to determine treatment efficacy but recent debates about the use of hydroxychloroquine for COVID-19 patients resulted in contradictory meta-analytical results. Different factors during the COVID-19 pandemic have impacted key features of conducting a good meta-analysis. Some meta-analyses did not evaluate or treat substantial heterogeneity (I2 > 75%); others did not include additional analysis for publication bias; none checked for evidence of p-hacking in the primary studies nor used recent methods (i.e., p-curve or p-uniform) to estimate the average population-size effect. These inconsistencies may contribute to contradictory results in the research evaluating COVID-19 treatments. A prominent example of this is the use of hydroxychloroquine, where some studies reported a large positive effect, whereas others indicated no significant effect or even increased mortality when hydroxychloroquine was used with the antibiotic azithromycin. In this paper, we first recall the benefits and fundamental steps of good quality meta-analysis. Then, we examine various meta-analyses on hydroxychloroquine treatments for COVID-19 patients that led to contradictory results and causes for this discrepancy. We then highlight recent tools that contribute to evaluate publication bias and p-hacking (i.e., p-curve, p-uniform) and conclude by making technical recommendations that meta-analyses should follow even during extreme global events such as a pandemic.

How Risk Signaling Influences Binge Drinking Impression Formation: An Evolutionary Experimental Approach.

Background. Evolutionary theory-driven alcohol prevention programs for adolescents are lacking. This study introduced a binge drinking impression formation paradigm to test whether emphasizing sexual dysfunction induced by alcohol abuse lowers positive attitudes and expectancies related to binge drinking when compared with cognitive or long-term health consequences. Method. In a between-subjects experiment, 269 French high school students (age, M = 15.94, SD = 0.93, 63.20% women) watched professional-quality videos emphasizing sexual impotence (n = 60), cognitive impairment (n = 72), or long-term effects (cancer, cardiovascular disease, n = 68) induced by alcohol and then had to evaluate a drinking scene. We predicted that the video on impotence would be the most impactful when compared with the other videos. Results. Results showed that women evaluated the target as less attractive after viewing the cognitive video compared with the video on impotence. Men were more willing to play sports against the target after viewing the cognitive video, compared with the video on impotence. Conclusions. These results showed that evolutionary meaning might shape impressions formed by participants depending on the context. This study calls for further replications using the same design and materials.

The Early Impact of the COVID-19 Lockdown on Stress and Addictive Behaviors in an Alcohol-Consuming Student Population in France.

Background: This study evaluated factors linked with perceived stress related to the COVID-19 pandemic and lockdown and addictive behaviors prior to and during lockdown in a sample of students who indicated engaging in alcohol consumption behaviors before lockdown. Methods: Cross-sectional study. French students from four universities participated in this study, and 2,760 students reported alcohol use. During the first week of lockdown, students reported their perceived levels of stress regarding COVID-19. Substance use and addictive behaviors were reported before and during lockdown, and media exposure, demographical, living conditions, and environmental stressors were reported during lockdown. Results: Women reported greater levels of stress (95% CI: 1.18 to 1.93, p < 0.001). Highly-stressed students also report less social support (95% CI: -1.04 to -0.39, p < 0.001) and were more likely to worry about the lockdown (95% CI: 0.27 to -0.65, p < 0.001). Alcohol-related problemswere more prevalent among the most stressed students (95% CI: 0.02 to 0.09, p = 0.004) as well as eating problems (95% CI: 0.04 to 0.36, p = 0.016) and problematic internet use (95% CI, 0.06 to 0.14, p < 0.001). Students reporting the highest levels of stress also indicated more compulsive eating during the previous seven days (95% CI, 0.21 to 1.19, p = 0.005). Conclusions: The level of stress was strongly related to four categories of variables: (i) intrinsic characteristics, (ii) addictive behaviors before lockdown, (iii) lockdown-specific conditions, and (iv) addictive behaviors during the lockdown. Several variables linked to COVID-19 were not directly linked with perceived stress, while perceived stress was found to correlate with daily life organization-related uncertainty and anticipated consequences of lockdown. Importantly, social support seems to be a protective factor on high level of stress.

COVID-19 pandemic lockdown and problematic eating behaviors in a student population.

BACKGROUND AND AIMS: Since mid-March 2020, over 3 billion people have been confined as a result of the COVID-19 pandemic. Problematic eating behaviors are likely to be impacted by the pandemic through multiple pathways. This study examined the relationships between stress related to lockdown measures and binge eating and dietary restriction in a population of French students during the first week of confinement. METHODS: A sample of undergraduate students (N = 5,738) completed an online questionnaire 7 days after lockdown measures were introduced. The survey comprised variables related to lockdown measures and the COVID-19-pandemic, mood, stress, body image, binge eating and dietary restriction during the past 7 days, as well as intent to binge eat and restrict in the following 15 days. RESULTS: Stress related to the lockdown was associated with greater likelihood of binge eating and dietary restriction over the past week and intentions to binge eat and restrict over the next 15 days. Greater exposure to COVID-19-related media was associated with increased eating restriction over the past week. Binge eating and restriction (past and intentions) were associated with established risk factors, including female gender, low impulse regulation, high body dissatisfaction, and having a concurrent probable eating disorder. DISCUSSION AND CONCLUSION: The higher the stress related to the first week of confinement, the higher the risk of problematic eating behaviors among students, particularly those characterized by eating-related concerns. Screening for risk factors and providing targeted interventions might help decrease problematic eating behaviors among those who are most vulnerable.

An Evolutionary Approach to Binge Drinking Impression Formation: A Cross-Cultural Comparison Between France and Peru.

Evolutionary medicine proposes studying alcohol use and abuse through the lens of modern evolutionary theory. This study ( https://osf.io/p48 uw/) follows this approach and uses an evolutionary framework to predict how young adults (18-35 years old) form impression of a binge drinker. We predicted that displaying sexual dysfunctions (short-term risk) in a binge drinking video would negatively influence attitudes and expectations of a target when compared to cognitive (short-term risk) or long-term deficits. In the following studies, we use a Zahavian framework to understand and influence impression formation of a male binge drinker among women (intersexual selection) and men (intrasexual competition) participants in a subsequent task. Via a randomized experimental online study in France (N = 177, M = 23.39 [4.91], 43.50% men) and a preregistered conceptual replication study in Peru (N = 176, M = 25.61 [4.76], 53.41% men), women exposed to a binge drinking video-describing sexual impotence after a binge drinking episode-tended to downgrade attractiveness evaluation of the binge drinker. However, male participants were not impacted by the different types of signals displayed in the videos. These results show that evolutionary theory could help us understand impression formation in binge drinking context and call for gender-specific health messages.

The other angle of Maslow's pyramid: How scarce environments trigger low-opportunity-cost innovations.

Is it true that innovation occurs only in abundant environments? Baumard defends that increased standards of living are a necessary condition for a change in life history strategy to help understand the Industrial Revolution. Here, we argue that many examples of innovations occur in scarce environments when there is near-zero opportunity cost. We suggest potential psychological pathways to explain this dual-cognitive process.

Do women expose themselves to more health-related risks in certain phases of the menstrual cycle? A meta-analytic review.

Researchers have increasingly examined the menstrual cycle as a potential source of day-to-day variation in women's cognitions, motivations, and behavior. Within this literature, several lines of research have examined the impact of the menstrual cycle on women's engagement in activities that could negatively affect their health (alcohol and tobacco consumption, sexual behavior, risk recognition). However, findings have been mixed, leaving it unclear whether women may expose themselves to more health-related risks during certain phases of the cycle. We conducted a meta-analysis of 22 published and four unpublished studies (N = 7529, https://osf.io/xr37j/). The meta-analysis revealed shifts across the menstrual cycle in women's sexual behavior with others and risk recognition (higher in ovulatory phase), whereas there was no consistent pattern of difference for alcohol and cigarette consumption. These findings help to clarify the proximate physiological and evolutionary mechanisms underlying women's health-related risk-taking and may inform new interventions.

Free love? On the relation between belief in free will, determinism, and passionate love.

Is love possible if we are not free? Some philosophers consider that true love is necessarily free, while others think that the nature of love makes it incompatible with a certain type of freedom. Here, we explored the relationship between feelings of passionate love, belief in free will and determinism across three online studies. In Study 1 (N=257), participants who believed strongly in free will (or determinism) expressed stronger passionate love. In Study 2 (N=305), we again found a positive association between belief in free will (or determinism) and passionate love, although the passionate love-determinism relationship seems more conditional. Finally, Study 3 (N=309) confirmed the relationship between belief in free will and passionate love but not between belief in determinism and passionate love. These findings, along with a meta-analysis, suggest that both beliefs in free will and determinism are compatible with passionate love.

Can the Knobe Effect Be Explained Away? Methodological Controversies in the Study of the Relationship Between Intentionality and Morality.

Based on the "Knobe Effect," Knobe has argued that moral evaluations can influence intentionality judgments. However, two methodological objections have been raised against this claim: first, that participants' answers do not accurately reflect what they think and, second, that the Knobe Effect can be fully explained by non-moral factors, such as the agent's desires or beliefs. In this article, we discuss these two methodological objections to the existence of the Knobe Effect and provide new evidence that moral evaluations can shape intentionality judgments. First, Study 1 shows that standard measures of intentionality do not overestimate participants' intentionality judgments. Second, Studies 2 and 3 suggest that participants' moral evaluations still mediate the impact of positive versus negative side-effects on judgments about intentional action, even when taking into account a whole range of non-moral factors. Results suggest that moral evaluations play an irreducible role in shaping our judgments about intentional action.

Preventing Alcohol Abuse Through Social Networking Sites: A First Assessment of a Two-Year Ecological Approach.

BACKGROUND: Prevention strategies to reduce alcohol use/consumption among young people are crucial to reducing alcohol-related deaths and preventing disease. This paper focuses on the effectiveness of a social networking site (SNS) alcohol prevention program targeted toward young people. OBJECTIVE: We hypothesized that the program would diminish the relation made by participants between alcohol and festive moments, and would result in a reduction of their declared consumption of alcohol at festive moments during the program. We also explored the interaction with the prevention program that was the most efficient. METHODS: The prevention program took the form of 3 lotteries over 2 years. The participants periodically received prevention messages, particularly on alcohol and festive moments (eg, videos on Facebook and short message service [SMS] text messages on their mobile phones). For the 3 periods, the participants had to answer questions exploring the level of their belief that alcohol consumption and festive moments are highly associated. A control group that did not participate in the prevention program was asked the same questions over the same number of days for the first 2 periods. During the second period, the participants were asked to answer questions about their alcohol consumption during parties. During the third period, we explored the interaction with the prevention program on the reduction of their belief that alcohol consumption and festive moments are associated. RESULTS: A total of 651 participants (age: mean 22.24, SD 4.10 years; women: n=430) during the first period, 301 participants (age: mean 21.27, SD 3.07 years; women n=199) during the second period, and 305 (age: mean 22.41, SD 4.65 years; women: n=190) during the third period correctly completed the survey. For the control group, 69 students completed the survey during the first period (age: mean 18.93, SD 1.14 years; women: n=59) and 50 during the second (age: mean 20.78, SD 1.94 years; women: n=45). We observed a significant reduction in the association of alcohol with festive moments in the participants over the 2 years (period 1: z=-4.80, P<.001; period 2: z=-2.11, P=.04; period 3: z=-2.30; P=.02), but not in the controls. We also observed a reduction in the number of glasses consumed during festive moments for the participants (z=-2.36, P=.02), but not for the controls during the second period. The third period showed that only the number of days since registration in the program had an impact on the reduction of the association of festive moments and alcohol consumption (t21=3.186, P=.005). CONCLUSIONS: The findings of this study suggest that the SNS prevention program is promising in preventing the association of alcohol with festive moments and, more generally, in impacting social norms.

Some like it hot: testosterone predicts laboratory eating behavior of spicy food.

In the present study, we analyzed the relationship between eating behavior of spicy food and endogenous testosterone. Participants included 114 males between the ages of 18 and 44 recruited from the community. They were asked to indicate their preferences regarding spicy food and were then asked to season a sample of mashed potatoes with pepper sauce and salt (control substance) prior to evaluating the spiciness of the meal. A positive correlation was observed between endogenous salivary testosterone and the quantity of hot sauce individuals voluntarily and spontaneously consumed with a meal served as part of a laboratory task. In contrast, significant correlations were not observed between testosterone and behavioral preference for salty foods. This study suggests that behavioral preference for spicy food among men is related to endogenous testosterone levels.