Label-free highly multimodal nonlinear endoscope.

We demonstrate a 2 mm diameter highly multimodal nonlinear micro-endoscope allowing label-free imaging of biological tissues. The endoscope performs multiphoton fluorescence (3-photon, 2-photon), harmonic generation (second-SHG and third-THG) and coherent anti-Stokes Raman scattering (CARS) imaging over a field of view of 200 µm. The micro-endoscope is based on a double-clad antiresonant hollow core fiber featuring a high transmission window (850 nm to 1800 nm) that is functionalized with a short piece of graded-index (GRIN) fiber. When combined with a GRIN micro-objective, the micro-endoscope achieves a 1.1 µm point spread function (PSF). We demonstrate 3-photon, 2-photon, THG, SHG, and CARS high resolution images of unlabelled biological tissues.

Photocycle of point defects in highly- and weakly-germanium doped silica revealed by transient absorption measurements with femtosecond tunable pump.

We report pump-probe transient absorption measurements addressing the photocycle of the Germanium lone pair center (GLPC) point defect with an unprecedented time resolution. The GLPC is a model point defect with a simple and well-understood electronic structure, highly relevant for several applications. Therefore, a full explanation of its photocycle is fundamental to understand the relaxation mechanisms of such molecular-like systems in solid state. The experiment, carried out exciting the sample resonantly with the ultraviolet (UV) GLPC absorption band peaked at 5.1 eV, gave us the possibility to follow the defect excitation-relaxation dynamics from the femto-picosecond to the nanosecond timescale in the UV-visible range. Moreover, the transient absorption signal was studied as a function of the excitation photon energy and comparative experiments were conducted on highly- and weakly-germanium doped silica glasses. The results offer a comprehensive picture of the relaxation dynamics of GLPC and allow observing the interplay between electronic transitions localized on the defect and those related to bandgap transitions, providing a clear evidence that the role of dopant high concentration is not negligible in the earliest dynamics.

Optimizing teacher basic need satisfaction in distributed healthcare contexts.

Optimizing teacher motivation in distributed learning environments is paramount to ensure high-quality education, as medical education is increasingly becoming the responsibility of a larger variety of healthcare contexts. This study aims to explore teaching-related basic need satisfaction, e.g. teachers' feelings of autonomy, competence and relatedness in teaching, in different healthcare contexts and to provide insight into its relation to contextual factors. We distributed a digital survey among healthcare professionals in university hospitals (UH), district teaching hospitals (DTH), and primary care (PC). We used the Teaching-related Basic Need Satisfaction scale, based on the Self-Determination theory, to measure teachers' basic needs satisfaction in teaching. We studied relations between basic need satisfaction and perceived presence of contextual factors associated with teacher motivation drawn from the literature. Input from 1407 healthcare professionals was analyzed. PC healthcare professionals felt most autonomous, UH healthcare professionals felt most competent, and DTH healthcare professionals felt most related. Regardless of work context, teachers involved in educational design and who perceived more appreciation and developmental opportunities for teaching reported higher feelings of autonomy, competence, and relatedness in teaching, as did teachers who indicated that teaching was important at their job application. Perceived facilitators for teaching were associated with feeling more autonomous and related. These results can be utilized in a variety of healthcare contexts for improving teaching-related basic need satisfaction. Recommendations for practice include involving different healthcare professionals in educational development and coordination, forming communities of teachers across healthcare contexts, and addressing healthcare professionals' intentions to be involved in education during job interviews.

Double clad tubular anti-resonant hollow core fiber for nonlinear microendoscopy.

We report the fabrication and characterization of the first double clad tubular anti-resonant hollow core fiber. It allows to deliver ultrashort pulses without temporal nor spectral distortions in the 700-1000 nm wavelength range and to efficiently collect scattered light in a high numerical aperture double clad. The output fiber mode is shaped with a silica microsphere generating a photonic nanojet, making it well suitable for nonlinear microendoscopy application. Additionally, we provide an open access software allowing to find optimal drawing parameters for the fabrication of tubular hollow core fibers.

Novel Gd3+-doped silica-based optical fiber material for dosimetry in proton therapy.

Optical fibers hold promise for accurate dosimetry in small field proton therapy due to their superior spatial resolution and the lack of significant Cerenkov contamination in proton beams. One known drawback for most scintillation detectors is signal quenching in areas of high linear energy transfer, as is the case in the Bragg peak region of a proton beam. In this study, we investigated the potential of innovative optical fiber bulk materials using the sol-gel technique for dosimetry in proton therapy. This type of glass is made of amorphous silica (SiO[Formula: see text]) and is doped with Gd[Formula: see text] ions and possesses very interesting light emission properties with a luminescence band around 314 nm when exposed to protons. The fibers were manufactured at the University of Lille and tested at the TRIUMF Proton Therapy facility with 8.2-62.9 MeV protons and 2-6 nA of extracted beam current. Dose-rate dependence and quenching were measured and compared to other silica-based fibers also made by sol-gel techniques and doped with Ce[Formula: see text] and Cu[Formula: see text]. The three fibers present strong luminescence in the UV (Gd) or visible (Cu,Ce) under irradiation, with the emission intensities related directly to the proton flux. In addition, the 0.5 mm diameter Gd[Formula: see text]-doped fiber shows superior resolution of the Bragg peak, indicating significantly reduced quenching in comparison to the Ce[Formula: see text] and Cu[Formula: see text] fibers with a Birks' constant, k[Formula: see text], of (0.0162 [Formula: see text] 0.0003) cm/MeV in comparison to (0.0333 [Formula: see text] 0.0006) cm/MeV and (0.0352 [Formula: see text] 0.0003) cm/MeV, respectively. To our knowledge, this is the first report of such an interesting k[Formula: see text] for a silica-based optical fiber material, showing clearly that this fiber presents lower quenching than common plastic scintillators. This result demonstrates the high potential of this inorganic fiber material for proton therapy dosimetry.

Coherent beam combining of a narrow-linewidth long-pulse Er3+-doped multicore fiber amplifier.

Active phase locking of a multicore erbium-doped fiber amplifier is demonstrated for 180 ns narrow-linewidth pulses at 1545 nm. A spatial light modulator is used at the input of the amplifier to control the optical phase of 7 beams injected in the hexagonally-arranged cores, ensuring efficient combining through a SPGD algorithm. At the output, combining is performed using a diffractive optical element. This experiment establishes multicore amplifiers as a promising way to scale the energy of Brillouin-limited pulsed amplifiers for LIDAR applications. We also present a simple lensless technique to measure phase shifts between pairs of adjacent channels that could be implemented in future active coherent combining systems.

Spectral division amplification of a 40 nm bandwidth in a multicore Yb doped fiber and femtosecond pulse synthesis with in-fiber delay line.

A compact multicore ytterbium doped fiber amplifier has been implemented according to the spectral division scheme. It was shown that it allows amplification of pulses with about 40 nm wide spectrum. Compensation of the different spectral bands delay through bending and twist of the multicore ribbon fiber followed by appropriate setting of their phase permitted the synthesis of pulses close to 100 fs duration.

Dual-wavelength synchronous ultrashort pulses from a mode-locked Yb-doped multicore fiber laser with spatially dispersed gain.

A laser based on a ribbon multicore ytterbium doped fiber where different cores amplified different spectral bands, has been mode-locked with a single saturable absorber mirror. Tunable dual wavelength synchronized picosecond pulses were obtained. Compensation of differential cavity roundtrip times was achieved in the fiber.

Enhanced structural sensitivity of hybrid-mode acoustic phonons in axially-varying photonic crystal fiber.

We report the observation of anti-crossings between hybrid-mode acoustic phonons in an axially-varying photonic crystal fiber. Our experimental results are analyzed using an electrostriction theory which reveals strong coupling between longitudinal and shear components of elastic wave. These anti-crossings are highly sensitive to the transverse fiber structure and thus could be potentially used for ultra-sensitive sensors and new opto-acoustic devices.

Reliability and validity of an extended clinical examination.

INTRODUCTION: An extended clinical examination (ECE) was administered to 85 final year medical students at the Radboud University Medical Centre in the Netherlands. The aim of the study was to determine the psychometric quality and the suitability of the ECE as a measurement tool to assess the clinical proficiency of eight separate clinical skills. METHODS: Generalizability studies were conducted to determine the generalizability coefficient and the sources of variance of the ECE. An additional D-study was performed to estimate the generalizability coefficients with altering numbers of stations. RESULTS: The largest sources of variance were found in skill difficulties (36.18%), the general error term (26.76%) and in the rank ordering of skill difficulties across the stations (21.89%). The generalizability coefficient of the entire ECE was above the 0.70 lower bound (G = 0.74). D studies showed that the separate skills could yield sufficient G coefficients in seven out of eight skills, if the ECE was lengthened from 8 to 14 stations. DISCUSSION: The ECE proved to be a reliable clinical assessment that enables examinees to compose a clinical reasoning path through self-obtained data. The ECE can also be used as an assessment tool for separate clinical skills.

Spatially dispersive amplification in a 12-core fiber and femtosecond pulse synthesis by coherent spectral combining.

A compact scheme is demonstrated for amplification and synthesis of ultrashort pulses by fiber amplifiers. Femtosecond pulses are split in 12 different spectral bands which are amplified separately in the 12 cores of a multicore ytterbium doped fiber. Combining the amplifier outputs together with the intensity and phase management of the spectral bands lead to short pulse synthesis with adjustable pulse shape. The scheme gave an x 92 enhancement in amplified power before the onset of nonlinear effects by comparison with standard stretcher free amplification in a single core fiber.

Experimental demonstration of modulation instability in an optical fiber with a periodic dispersion landscape.

We report the experimental demonstration of a modulation instability (MI) process assisted by a periodic dispersion modulation in an optical fiber. We observe the spontaneous growth of more than 10 pairs of MI sidebands spanning over more than 10 THz thanks to a quasi-phase-matched process.

Spatially dispersive scheme for transmission and synthesis of femtosecond pulses through a multicore fiber.

A new scheme is presented for fiber transmission of ultrashort laser pulses. A dispersive device divides the input pulses into spatially separated spectral components which are individually launched in the different channels of a multicore fiber before being recombined at the output by a second dispersive device. The parallel transmission of narrow spectral bands avoids self-phase modulation and could be appropriate to deliver high peak power pulses. Phase management of the spectral bands by an active element offers recovery of the seed pulse duration at the fiber output as well as pulse shaping capabilities. Both are reported in a proof of concept experiment using 190 fs input pulses and a 5 cores polarization maintaining fiber. Extension of the concept to femtosecond pulses amplification is suggested.

Spheroidal Fabry-Perot microcavities in optical fibers for high-sensitivity sensing.

All-optical-fiber Fabry-Perot interferometers (FPIs) with microcavities of different shapes were investigated. It was found that the size and shape of the cavity plays an important role on the performance of these interferometers. To corroborate the analysis, FPIs with spheroidal cavities were fabricated by splicing a photonic crystal fiber (PCF) with large voids and a conventional single mode fiber (SMF), using an ad hoc splicing program. It was found that the strain sensitivity of FPIs with spheroidal cavities can be controlled through the dimensions of the spheroid. For example, a FPI whose cavity had a size of ~10x60 µm exhibited strain sensitivity of ~10.3 pm/µÎµ and fringe contrast of ~38 dB. Such strain sensitivity is ~10 times larger than that of the popular fiber Bragg gratings (~1.2 pm/µÎµ) and higher than that of most low-finesse FPIs. The thermal sensitivity of our FPIs is extremely low (~1pm/°C) due to the air cavities. Thus, a number of temperature-independent ultra-sensitive microscopic sensors can be devised with the interferometers here proposed since many parameters can be converted to strain. To this end, simple vibration sensors are demonstrated.

Linear and nonlinear optical properties of gold nanoparticle-doped photonic crystal fiber.

We report on the production of air/silica photonic crystal fiber doped with gold nanoparticles. The stack-and-draw technique was used to combine a gold nanoparticles-doped silica core rod synthesized by the sol-gel route with capillaries drawn from commercially available silica tubes. The presence of nanoparticles in the core region was confirmed at the different steps of the process down to the fiber geometry, even after multiple drawings at ~2000 °C. Optical properties of the fiber were investigated and put in evidence the impact of gold nanoparticles on both linear and nonlinear transmission.

Significant reduction of power fluctuations at the long-wavelength edge of a supercontinuum generated in solid-core photonic bandgap fibers.

We show that the infrared edge of supercontinua generated in solid core photonic bandgap fibers is characterized by a very different temporal behavior than the one obtained in standard fibers. In particular, pulse-to-pulse spectral power fluctuations are significantly reduced near the bandgap edge, and the statistical distribution is quasi-gaussian. The spectral dynamics of this process and statistical properties are investigated experimentally and confirmed by numerical simulations. The reduction of power fluctuations originates from the cancellation of the soliton self-frequency shift near the bandgap edge.

Optical properties of Bismuth-doped silica core photonic crystal fiber.

Optical properties of a Bismuth-doped pure silica sol-gel core photonic crystal fiber (PCF) were investigated. We report on the absorption, CW luminescence and time resolved luminescence spectra at different excitation wavelengths at room temperature. Complex structure of the energy levels of Bismuth-connected centers in pure silica glass is put in evidence.

Photonic crystal fiber mapping using Brillouin echoes distributed sensing.

In this paper we investigate the effect of microstructure irregularities and applied strain on backward Brillouin scattering by comparing two photonic crystal fibers drawn with different parameters in order to minimize diameter and microstructure fluctuations. We fully characterize their Brillouin properties including the gain spectrum and the critical power. Using Brillouin echoes distributed sensing with a high spatial resolution of 30 cm we are able to map the Brillouin frequency shift along the fiber and get an accurate estimation of the microstructure longitudinal fluctuations. Our results reveal a clear-cut difference of longitudinal homogeneity between the two fibers.

White-light cw-pumped supercontinuum generation in highly GeO(2)-doped-core photonic crystal fibers.

GeO(2)-doped-core photonic crystal fibers show greatly enhanced Kerr and Raman responses with respect to pure silica without any significant modification of the group-velocity dispersion curve. We show that such fibers allow a significant improvement of cw-pumped supercontinuum generation. We report for the first time to our knowledge the generation of a white-light cw-pumped supercontinuum spanning from 470 nm to more than 1750 nm.

Control of supercontinuum generation and soliton self-frequency shift in solid-core photonic bandgap fibers.

We experimentally investigate the nonlinear propagation of subnanosecond pulses in solid-core photonic bandgap fibers. By launching pulses with a few kilowatts peak power, a flat supercontinuum is generated. The long-wavelength edge of the supercontinuum can be controlled thanks to the original linear properties inherent to solid-core photonic bandgap fibers. This allows one to tailor the generated supercontinuum radiation and to keep it over a given spectral range of interest without any significant power loss.