Syndrome auriculotemporal.

Two cases of auriculotemporal syndrome are presented in two male children that began in the first years of life to present reactions of linear erythema itinerary on the cheeks after eating several foods. The allergologic study with these foods was negative, reproducing the clinical picture after their ingestion.

Syndrome auriculotemporal / Síndrome auriculotemporal

Two cases of syndrome auriculotemporal are presented in two male children that begin in the first years of life to present reactions of eritema of lineal itinerary in cheeks after eating several foods. The allergologic study with these foods was negative, reproducing the clinic after their ingesta (AU)

Se presentan 2 casos de síndrome auriculotemporal en niños varones que se inició en los primeros años de vida como reacciones eritematosas de itinerario lineal en las mejillas después de la ingestión de diversos alimentos.El estudio alergológico con estos alimentos fue negativo, reproduciéndose la clínica después de su ingesta (AU)

Evaluation of drug-related hypersensitivity reactions in children.

Patients with drug reactions are often referred to allergists for "allergy". Skin testing and clinical history seem to have a good negative predictive value, however, although drug challenge could be dangerous, it is the only way to confirm the diagnosis. We aimed to demonstrate that most children with a history of non-life-threatening drug reactions do not have a true drug allergy and examined the use of drug challenge in childhood. Patients with reactions were referred to our clinic by pediatricians. In 1 year, 354 reactions were studied in 239 children. Patients were classified according to their positive or negative history of drug allergy. Skin prick testing was done in all cases. Exclusion criteria for challenge included drug anaphylaxis, Stevens-Johnson syndrome, systemic reactions with severe concomitant illness, beta-inhibitor drug therapy or positive skin test to the implicated drug with a positive history. It was found that the beta-lactam antibiotics were involved in 50% of suspected reactions, aspirin in 10% and sulfonamides in 9%. Histories were considered positive only in 25%. Drug challenges confirmed only 4% of all reactions. It was concluded that drug challenge may be the gold standard for most childhood reactions that are considered to be allergic, non-life-threatening and drug-related. Only 4% of these suspected reactions were exclusively caused by drug allergy.

Nonspecific bronchial hyperresponsiveness and development of asthma in children with hay fever.

It has been suggested that patients with allergic rhinitis who present nonspecific bronchial hyperresponsiveness (BHR) are those most likely to develop asthma. Therefore, a study was conducted in children with rhinoconjunctivitis to ascertain whether BHR to methacholine might predict the development of asthma in these patients. Fifteen patients with hay fever and no previous symptoms of asthma were selected. All underwent clinical symptom tests and methacholine tests, during the pollen season in the 4 consecutive years following the start of the study. At the end of this period, 5 patients had developed asthma. It may thus be affirmed that, in this group, neither the presence nor the degree of previous BHR was useful for predicting which patients would later develop asthma.

Systemic anaphylaxis due to hepatic hydatid disease.

Hydatidosis can be a cause of anaphylaxis; it has been clearly established that the accidental rupture of a cyst during surgery can provoke severe anaphylactic reactions. Spontaneous anaphylaxis secondary to hydatid disease is much less frequent. We report three patients who presented with spontaneous anaphylaxis without apparent cause. Serological and ultrasonographic studies showed hepatic hydatid disease. Two years after surgical resection of cysts, no new episodes of anaphylaxis have occurred. Hydatidosis is a cause of apparently spontaneous anaphylaxis and this is likely due to an IgE-mediated mechanism.

Systemic anaphylaxis following parenteral orgotein administration.

We present a patient displaying a systemic anaphylactic reaction after local infiltration of orgotein. An IgE-mediated mechanism was demonstrated with skin tests and specific IgE measurement. It is concluded that orgotein can rarely cause IgE-mediated anaphylaxis.